99935-65-6Relevant articles and documents
The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element
Wiley, Michael R.,Weir, Leonard C.,Briggs, Steven L.,Chirgadze, Nickolay Y.,Clawson, David,Gifford-Moore, Donetta S.,Schacht, Aaron L.,Smith, Gerald F.,Vasudevan, Vasu,Zornes, Larry L.,Klimkowski, Valentine J.
, p. 2767 - 2772 (2007/10/03)
Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Deri