99940-35-9Relevant academic research and scientific papers
Synthesis of 1,2-amino alcohols by decarboxylative coupling of amino acid derived α-amino radicals to carbonyl compounds: Via visible-light photocatalyst in water
Pan, Shulei,Jiang, Min,Hu, Jinjin,Xu, Ruigang,Zeng, Xiaofei,Zhong, Guofu
supporting information, p. 336 - 341 (2020/02/13)
A general and efficient visible-light photoredox-catalysed decarboxylative radical coupling reaction of N-aryl amino acids with aldehydes or ketones for the synthesis of various 1,2-amino alcohols by using water as the solvent at room temperature is described. This protocol is characterised by broad substrate scopes, mild reaction conditions and amenability to gram-scale synthesis, which opens up a simple, mild but effective method to produce 1,2-amino alcohols from readily available starting materials.
Gold-catalyzed 1,2-difunctionalizations of aminoalkynes using only N- and O-containing oxidants
Mukherjee, Anupam,Dateer, Ramesh B.,Chaudhuri, Rupsha,Bhunia, Sabyasachi,Karad, Somnath Narayan,Liu, Rai-Shung
supporting information; experimental part, p. 15372 - 15375 (2011/11/07)
We report two viable routes for the 1,2-difunctionalization of aminoalkynes using only oxidants. In the presence of a gold catalyst, nitrones enable the oxoamination of aminoalkynes 1 to form 2-aminoamides 2. With a suitable gold catalyst, nitrosobenzenes implement an alkyne/nitroso metathesis of the same substrates to give 2-oxoiminylamides 3. These two novel oxidations also provide 1,2-aminoalcohols with opposite regioselectivity via NaBH4 reduction in situ.
