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l-Threitol-1,4-bismethanesulfonate

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l-Threitol-1,4-bismethanesulfonate

EINECS 206-081-0
CAS No. 299-75-2 Density 1.562g/cm3
PSA 143.96000 LogP -0.17780
Solubility N/A Melting Point 76-78 °C
Formula C6H14 O8 S2 Boiling Point 607°Cat760mmHg
Molecular Weight 278.304 Flash Point 320.9°C
Transport Information N/A Appearance N/A
Safety Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx. Risk Codes N/A
Molecular Structure Molecular Structure of 299-75-2 (treosulfan) Hazard Symbols N/A
Synonyms

1,2,3,4-Butanetetrol,1,4-dimethanesulfonate, [S-(R*,R*)]-;Threitol, 1,4-dimethanesulfonate,(2S,3S)- (8CI);(2S,3S)-Threitol 1,4-bismethanesulfonate;L-Threitol1,4-bis(methanesulfonate);NSC 39069;Ovastat;Threosulphan;Treosulfan;Treosulphan;Tresulfan;

Article Data 11

l-Threitol-1,4-bismethanesulfonate Chemical Properties

IUPAC Name: (2,3-Dihydroxy-4-methylsulfonyloxybutyl) methanesulfonate
Synonyms: 1,2,3,4-1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (R*,R*)- (9CI) ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (R*,S*)- (9CI) ; 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, (S-(R*,R*))- (9CI) ; 2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate
CAS NO: 299-75-2
Molecular Formula of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :C6H14O8S2
Molecular Weight of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :278.3006
Molecular Structure of l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) :
EINECS: 206-081-0
Index of Refraction: 1.517
Surface Tension: 64.4 dyne/cm
Density: 1.562 g/cm3
Flash Point: 320.9 °C
Enthalpy of Vaporization: 103.49 kJ/mol
Boiling Point: 607 °C at 760 mmHg
Vapour Pressure: 2.86E-17 mmHg at 25°C
Appearance:Odorless white crystalline powder.

l-Threitol-1,4-bismethanesulfonate Uses

 l-Threitol-1,4-bismethanesulfonate (CAS NO.299-75-2) is mainly used in the clinical treatment of ovarian cancer, but also for treatment of tumor resection after adjuvant therapy.

l-Threitol-1,4-bismethanesulfonate Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 222mg/kg (222mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: LEUKOPENIA

BLOOD: OTHER CHANGES
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.
monkey LDLo intravenous 222mg/kg (222mg/kg) BLOOD: LEUKOPENIA

BLOOD: AGRANULOCYTOSIS

BLOOD: OTHER CHANGES
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 203, 1965.

 

l-Threitol-1,4-bismethanesulfonate Consensus Reports

IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 363.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 ,1981,p. 341.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

l-Threitol-1,4-bismethanesulfonate Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.
RIDADR 2811
HazardClass 6.1(b)
PackingGroup III

l-Threitol-1,4-bismethanesulfonate Specification

1.Air & Water Reactions :Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .
2.Fire Hazard :Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

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