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EINECS 278-903-6
CAS No. 78415-72-2 Density 1.288 g/cm3
PSA 69.54000 LogP 1.61698
Solubility DMSO: >10 mg/mL Melting Point >3000C
Formula C12H9N3O Boiling Point 448.685 °C at 760 mmHg
Molecular Weight 211.22 . Flash Point 225.157 °C
Transport Information UN 2811 6.1/PG 3 Appearance Crystalline solid
Safety 36/37/39-45-22 Risk Codes 23/24/25-26/27/28
Molecular Structure Molecular Structure of 78415-72-2 (Milrinone) Hazard Symbols ToxicT, VeryT+

6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;Milrinone,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile;1,6-Dihydro-2-methyl-6-oxo(3,4-bipyridine)-5-carbonitrile;sodium sulfonate;6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile;(3,4-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-;Milrinona [Spanish];WIN 47203-2;Milrinone [USAN:BAN:INN];YM 018;Milrinonum [Latin];Win 47203;[3,4'-Bipyridine]-5-carbonitrile,1,6-dihydro- 2-methyl-6-oxo-;Milrinone (JAN/USAN);Mirinone;


Milrinone Chemical Properties

Molecular Formula: C12H9N3O
Molecular Weight: 211.22
EINECS: 278-903-6 
Index of Refraction: 1.622
Molar Refractivity: 57.76 cm3
Molar Volume: 164 cm3
Surface Tension: 60.2 dyne/cm
Density: 1.28 g/cm3
Flash Point: 225.2 °C
Enthalpy of Vaporization: 70.72 kJ/mol
Boiling Point: 448.7 °C at 760 mmHg
Vapour Pressure: 3.04E-08 mmHg at 25 °C
Storage tempreture: 2-8 °C
Solubility: DMSO: >10 mg/mL
Appearance: Off-white solid
Structure of Milrinone (CAS NO.78415-72-2):
IUPAC Name: 6-Methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Canonical SMILES: CC1=C(C=C(C(=O)N1)C#N)C2=CC=NC=C2
InChI: InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
Product Category of Milrinone (CAS NO.78415-72-2): Active Pharmaceutical Ingredients;API;Heterocycles;Intermediates & Fine Chemicals;Cyclic Nucleotide related

Milrinone Uses

 Milrinone (CAS NO.78415-72-2) is used in the management of heart failure only when conventional treatment with vasodilators and diuretics has proven insufficient.

Milrinone Toxicity Data With Reference


orl-rat LD50:91 mg/kg

    NCDREP    New Cardiovascular Drugs. 3 (1985),245.

scu-rat LD50:58 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 27 (1996),652.

ivn-rat LD50:73 mg/kg

    NCDREP    New Cardiovascular Drugs. 3 (1985),245.

orl-mus LD50:137 mg/kg

    NCDREP    New Cardiovascular Drugs. 3 (1985),245.

scu-mus LD50:62 mg/kg

    IYKEDH    Iyakuhin Kenkyu. Study of Medical Supplies. 27 (1996),652.

ivn-mus LD50:79 mg/kg

    NCDREP    New Cardiovascular Drugs. 3 (1985),245.

Milrinone Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.
The Hazard Codes:  T,T+
The Risk Statements information:
23/24/25:  Toxic by inhalation, in contact with skin and if swallowed 
26/27/28:  Very Toxic by inhalation, in contact with skin and if swallowed 
The Safety Statements information:
22:  Do not breathe dust 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
RIDADR: UN 2811 6.1/PG 3

Milrinone Specification

 Milrinone , its cas register number is 78415-72-2. It also can be called 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile ; Milrinonum ; and (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo- . It  is a phosphodiesterase III inhibitor, and enhances relaxation of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum.

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