Material Safety Data Sheet
acc. to OSHA and ANSI

1 Identification of substance:
Product details:
Product name: 4-Amino-2,5-difluorobenzonitrile
2 Composition/Data on components:
Chemical characterization:
Description: (CAS#)
4-Amino-2,5-difluorobenzonitrile (CAS# 112279-61-5): 100%

3 Hazards identification
Hazard description:


T Toxic


Information pertaining to particular dangers for man and environment
R 25 Toxic if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Classification system
HMIS ratings (scale 0-4)
(Hazardous Materials Identification System)
HEALTH 2 Health (acute effects) = 2
Flammability = 1
FIRE 1
Reactivity = 1
REACTIVITY 1




4 First aid measures
General information
Immediately remove any clothing soiled by the product.
In case of irregular breathing or respiratory arrest provide artificial
respiration.
After inhalation
Supply fresh air. If required, provide artificial respiration. Keep
patient warm.
Seek immediate medical advice.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
Seek immediate medical advice.




 Material Safety Data Sheet
acc. to OSHA and ANSI

Product name: 4-Amino-2,5-difluorobenzonitrile

After eye contact
Rinse opened eye for several minutes under running water. Then consult a
doctor.
After swallowing
Do not induce vomiting; immediately call for medical help.
Seek immediate medical advice.

5 Fire fighting measures
Suitable extinguishing agents
Carbon dioxide, extinguishing powder or water spray. Fight larger fires
with water spray or alcohol resistant foam.
Special hazards caused by the material, its products of combustion or
resulting gases:
In case of fire, the following can be released:
Carbon monoxide and carbon dioxide
Nitrogen oxides (NOx)
Hydrogen fluoride (HF)
Hydrogen cyanide (HCN)
Protective equipment:
Wear self-contained respirator.
Wear fully protective impervious suit.

6 Accidental release measures
Person-related safety precautions:
Wear protective equipment. Keep unprotected persons away.
Ensure adequate ventilation
Measures for environmental protection:
Do not allow material to be released to the environment without proper
governmental permits.
Measures for cleaning/collecting:
Dispose contaminated material as waste according to item 13.
Ensure adequate ventilation.
Additional information:
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

7 Handling and storage
Handling
Information for safe handling:
Keep container tightly sealed.
Store in cool, dry place in tightly closed containers.
Ensure good ventilation at the workplace.
Information about protection against explosions and fires:
Keep ignition sources away.
Storage
Requirements to be met by storerooms and receptacles:
No special requirements.
Information about storage in one common storage facility:
Store away from oxidizing agents.
Further information about storage conditions:
Keep container tightly sealed.




 Material Safety Data Sheet
acc. to OSHA and ANSI

Product name: 4-Amino-2,5-difluorobenzonitrile

Store in cool, dry conditions in well sealed containers.

8 Exposure controls and personal protection
Additional information about design of technical systems:
Properly operating chemical fume hood designed for hazardous chemicals
and having an average face velocity of at least 100 feet per minute.
Components with limit values that require monitoring at the workplace:
Not required.
Additional information: No data
Personal protective equipment
General protective and hygienic measures
The usual precautionary measures for handling chemicals should be
followed.
Keep away from foodstuffs, beverages and feed.
Remove all soiled and contaminated clothing immediately.
Wash hands before breaks and at the end of work.
Avoid contact with the eyes and skin.
Breathing equipment:
Use suitable respirator when high concentrations are present.
Protection of hands:
Impervious gloves
Check protective gloves prior to each use for their proper condition.
Material of gloves
The selection of suitable gloves not only depends on the material, but
also on quality. Quality will vary from manufacturer to manufacturer.
Eye protection: Safety glasses
Body protection: Protective work clothing.


9 Physical and chemical properties:
General Information
Form: Powder
Odor: Not determined
Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Sublimation temperature / start: Not determined
Flash point: Not applicable
Ignition temperature: Not determined
Decomposition temperature: Not determined
Danger of explosion: Product does not present an
explosion hazard.
Explosion limits:
Lower: Not determined
Upper: Not determined
Vapor pressure: Not determined
Density: Not determined




 Material Safety Data Sheet
acc. to OSHA and ANSI

Product name: 4-Amino-2,5-difluorobenzonitrile

Solubility in / Miscibility with
Water: Not determined


10 Stability and reactivity
Thermal decomposition / conditions to be avoided:
Decomposition will not occur if used and stored according to
specifications.
Materials to be avoided: Oxidizing agents
Dangerous reactions No dangerous reactions known
Dangerous products of decomposition:
Carbon monoxide and carbon dioxide
Nitrogen oxides
Hydrogen fluoride
Hydrogen cyanide (prussic acid)


11 Toxicological information
Acute toxicity:
Primary irritant effect:
on the skin: Irritant to skin and mucous membranes.
on the eye: Irritating effect.
Sensitization: No sensitizing effects known.
Subacute to chronic toxicity:
Absorption into the body may lead to the formation of methemoglobin,
producing cyanosis, and marked fall in blood pressure leading to
collapse, coma and possibly death. Onset may be delayed 2-4 hours or
longer.
Many nitriles resemble cyanides in toxicity. Exposure to nitriles may
cause increased salivation, flushing of the face, eye and respiratory
tract irritation, shallow respiration, nausea, vomiting, weakness,
headache and diarrhea. Jaundice, anemia, and leucocytosis has been
reported in some cases. Some are suspected carcinogens, teratogens or
mutagens.
Additional toxicological information:
To the best of our knowledge the acute and chronic toxicity of this
substance is not fully known.
No classification data on carcinogenic properties of this material is
available from the EPA, IARC, NTP, OSHA or ACGIH.

12 Ecological information:
General notes:
Do not allow material to be released to the environment without proper
governmental permits.

13 Disposal considerations
Product:
Recommendation
Consult state, local or national regulations to ensure proper disposal.




 Material Safety Data Sheet
acc. to OSHA and ANSI

Product name: 4-Amino-2,5-difluorobenzonitrile

Uncleaned packagings:
Recommendation: Disposal must be made according to official regulations.


14 Transport information
DOT regulations:




Hazard class: 6.1
Identification number: UN3276
Packing group: III
Proper shipping name (technical
name): NITRILES, TOXIC, N.O.S. (4-Amino-2,5-
difluorobenzonitrile)
Label 6.1
Land transport ADR/RID (cross-border)




ADR/RID class: 6.1 Toxic substances
Danger code (Kemler): 60
UN-Number: 3276
Packaging group: III
Description of goods: 3276 NITRILES, TOXIC, N.O.S. (4-Amino-
2,5-difluorobenzonitrile)
Maritime transport IMDG:




IMDG Class: 6.1
UN Number: 3276
Label 6.1
Packaging group: III
Proper shipping name: NITRILES, TOXIC, N.O.S. (4-Amino-2,5-
difluorobenzonitrile)
Air transport ICAO-TI and IATA-DGR:




ICAO/IATA Class: 6.1
UN/ID Number: 3276
Label 6.1
Packaging group: III




 Material Safety Data Sheet
acc. to OSHA and ANSI

Product name: 4-Amino-2,5-difluorobenzonitrile

Proper shipping name: NITRILES, TOXIC, N.O.S. (4-Amino-2,5-
difluorobenzonitrile)


15 Regulations
Product related hazard informations:
Hazard symbols:
T Toxic
Risk phrases:
25 Toxic if swallowed.
36/37/38 Irritating to eyes, respiratory system and skin.
Safety phrases:
20 When using do not eat or drink.
26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
36/37 Wear suitable protective clothing and gloves.
45 In case of accident or if you feel unwell, seek medical advice
immediately.
60 This material and its container must be disposed of as hazardous
waste.
National regulations
This product is not listed in the U.S. Environmental Protection Agency
Toxic Substances Control Act Chemical Substance Inventory. Use of this
product is restricted to research and development only.
Some or all of the components of this product are not listed on the
Canadian Domestic Substances List (DSL) or the Canadian Non-Domestic
Substances List (NDSL).
Information about limitation of use:
For use only by technically qualified individuals.



4-AMINO-2,5-DIFLUOROBENZONITRILE