Welcome to LookChem.com Sign In | Join Free

CAS No:123456789    This site contains about 108,618 DataSheet documents.

Position: Index > Categories > Semiconductors and Actives
CAS : 60561-17-3 ProductName : Sufentanil citrate
MSDS Number: SUFTL Effective Date: 12/10/2003 Supercedes: 7/1/1999
Eye Contact:
Mild irritant but will also have a strong narcotic effect (pupil constriction) and the eye may serve as an
absorption route to the body in general.
Chronic Exposure:
Caution, may be habit forming.
Aggravation of Pre-existing Conditions:
No information found.

4. First Aid Measures
Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a
physician.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an
unconscious person.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and
shoes. Call a physician, immediately. Wash clothing before reuse.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids
occasionally. Get medical attention immediately.
Note to Physician:
The principal sign of serious overdose to sufentanyl include stupor and respiratory depression. Treatment for
these effects due to fentanyl is the same as for overdose by other opioids: airway maintenance, ventilation
support, and administration of a narcotic antagonist such as naloxone (Narcan?) beginning with 0.4 to 2 mg
intravenously and repeating every three minutes as clinically indicated. Intramuscular or subcutaneous
administration may be necessary if the intravenous route is not available.


5. Fire Fighting Measures
Fire:
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Explosion:
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
dust explosion hazard.
Fire Extinguishing Media:
Water spray, dry chemical, alcohol foam, or carbon dioxide.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus
with full facepiece operated in the pressure demand or other positive pressure mode. Follow handling
guidance appropriate for OEB-3 potent compounds, (see Section 7).

6. Accidental Release Measures
Ventilate area of leak or spill. Remove all sources of ignition. Wear appropriate personal protective equipment
as specified in Section 8, and follow handling guidance appropriate for OEB-3 potent compounds, (see
Section 7). Isolate hazard area. Keep unnecessary and unprotected personnel from entering. All clean-up
operations should be witnessed by more than one individual.
Spills: Carefully sweep up material into an appropriate container and save for reclamation or disposal. Use
non-sparking tools and equipment. Do not flush to sewer! The amount of material collected should be
assessed and documented.



MSDS Number: SUFTL Effective Date: 12/10/2003 Supercedes: 7/1/1999

7. Handling and Storage
Store in a tightly sealed light impervious metal container in a cool dry ventilated area. CONTROLLE SUBSTANCE. Location of storage area must comply with all Drug Enforcement Agency regulations.
Containers of this material may be hazardous when empty since they retain product residues (dust, solids);
observe all warnings and precautions listed for the product.

Sufentanyl has potent pharmacological activity and is classified as an OEB-3* material. Handling practices
for OEB-3 substances are described below:
Laboratory

* Wear appropriate gloves, lab coat, and safety glasses. Use good lab practices.
* A designated area is required for handling compounds.
* Work surfaces are to be cleaned daily. If lab bench absorbent paper is used, it is to be changed at least
daily.
* High-energy operations such as milling, particle sizing, spraying or fluidizing should be done within an
approved emission control or containment system.
* Develop cleaning procedures and techniques that limit potential exposure.
* Powders Handling:
To prevent contamination and overexposure, no open handling of powder should be allowed. Powder
handling operations are to be done in a powders weighing hood, a glove box, or other equivalent ventilated
containment system. In situations where these ventilated containment hoods have not been installed, a non-
ventilated enclosed containment hood should be used. Pending changes resulting from additional air
monitoring data, up to 300 mg can be handled outside of an enclosure provided that no grinding, crushing or
other dust-generating process occurs. An air-purifying respirator (P95 or other type providing a higher level of
protection) should be worn by all personnel in the immediate area in cases where non-ventilated containment
is used, where significant amounts of material (e.g., more than 2 grams) are used, or where the material may
become airborne (as through grinding, etc.). Powder should be put into solution or a closed or covered
container after handling. If using a ventilated enclosure that has not been validated, wear a half-mask
respirator equipped with HEPA cartridges until the enclosure is validated for use.

* Solutions Handling:
- Solutions can be handled outside a containment system or without local exhaust ventilation during
procedures with no potential for aerosolization. If the procedures have a potential for aerosolization, an air-
purifying respirator (P95 or other type providing a higher level of protection) is to be worn by all personnel in
the immediate area.
- Solutions used for procedures where aerosolization may occur (e.g., vortexing, pumping) are to be handled
within a containment system or with local exhaust ventilation. In situations where this is not feasible (may
include animal dosing), an air-purifying respirator (P95 or other type providing a higher level of protection) is to
be worn by all personnel in the immediate area.
- If using a ventilated enclosure that has not been validated, wear a half-mask respirator equipped with HEPA
cartridges until the enclosure is validated for use.
-Ensure gloves are protective against solvents in use.

Pilot Plant and Production

* Wear appropriate gloves; lab coat, nylon coveralls or disposable Tyvek suit; safety glasses, safety shoes,
and disposable booties. Use good manufacturing practices (i.e., cGMPs).
* Protective garment (coveralls, Tyvek, lab coat) is not to be worn outside the work area.
* Clean/dirty/decontamination areas are to be established.
* Negative/positive air pressure relationships and buffer zones required (i.e., ante-room/degowning
room/airlock).
* Area access is to be restricted.
* High-energy operations such as milling, particle sizing, spraying or fluidizing should be done within an
approved emission control or containment system.
* Develop cleaning procedures and techniques that limit potential exposure.

* Powders Handling
- Emphasis is to be placed on closed material transfer systems and process containment, with no open

MSDS Number: SUFTL Effective Date: 12/10/2003 Supercedes: 7/1/1999
propanetricarboxylate)
Hazard Class: 6.1
UN/NA: UN2811 Packing Group: II
Information reported for product/size: all sizes



15. Regulatory Information
Chemical Inventory Status
---Canada---
Ingredient TSCA EC Japan Australia Korea DSL NDSL Phil.
Sufentanil citrate (60561-17-3) Exempt Yes No Yes No No No No

Federal, State & International Regulations
---SARA 302--- -----------SARA 313----------- -RCRA- -TSCA-
Ingredient RQ TPQ List Chemical Catg. CERCLA 261.33 8(d)
Sufentanil citrate (60561-17-3) No No No No No No No

Chemical Weapons Convention: No TSCA 12(b): No CDTA: No
SARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: No Reactivity: No (Pure / Solid)
Australian Hazchem Code: 2XE Australian Poison Schedule: S8
WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.


16. Other Information
NFPA Ratings:
Health: 4 Flammability: 1 Reactivity: 1
Label Hazard Warning:
DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. POTENT
NARCOTIC.
Label Precautions:
Do not breathe dust.
Do not get in eyes, on skin, or on clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Wear gloves and protective clothing.
Label First Aid:
In all cases call a physician immediately. If swallowed, induce vomiting immediately as directed by medical
personnel. Never give anything by mouth to an unconscious person. If inhaled, remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give oxygen. In case of contact, immediately flush
eyes or skin with plenty of water for at least 15 minutes.
Product Use:
Medication: Analgesic agent
Revision Information:
MSDS Section(s) changed since last revision of document include: 3, 4, 5, 6, 7, 8, 13, 14, 15, 16.
Disclaimer:
Mallinckrodt provides the information contained herein in good faith but makes no representation as to its
comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary
handling of the material by a properly trained person using this product. Individuals receiving the information
must exercise their independent judgment in determining its appropriateness for a particular purpose.
MALLINCKRODT MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED,

MSDS Number: SUFTL Effective Date: 12/10/2003 Supercedes: 7/1/1999
INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A
PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE
PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT WILL NOT BE
RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.
Prepared By: Environmental Health & Safety
Phone Number: (314) 654-1600 (U.S.A.)






SUFENTANIL CITRATE   

Related Product