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CAS : 78755-81-4 ProductName : Flumazenil
MSDS  :
 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic
acid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethyl
ester
CAS  
:
 78755-81-4
SYNONYMS  
:
 * Anexate
* Ethyl
8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine
-3-carboxylate
* Flumazenil
* Flumazepil
* Lanexat
* Ro-15-1788

Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers
[ 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylicacid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethylester 78755-81-4 ]
                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI2922170
CHEMICAL NAME           : 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic
                          acid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethyl
                          ester
CAS REGISTRY NUMBER     : 78755-81-4
BEILSTEIN REFERENCE NO. : 4763661
LAST UPDATED            : 199612
DATA ITEMS CITED        : 15
MOLECULAR FORMULA       : C15-H14-F-N3-O3
MOLECULAR WEIGHT        : 303.32
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Anexate
   * Ethyl  
   8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine  
   -3-carboxylate
   * Flumazenil
   * Flumazepil
   * Lanexat
   * Ro-15-1788
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 5700 ng/kg/C
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Cardiac - arrhythmias (including changes in conduction)
   Cardiac - change in rate
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   304,1415,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
   Behavioral - aggression
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 339,488,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 4 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - EKG changes not diagnostic of specified effects
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   PECAE5 Pediatric Emergency Care.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1985-  Volume(issue)/page/year: 11,186,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1360 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,402,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,402,1982
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,201,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,201,1992
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,201,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 21 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PNPPD7 Progress in Neuro-Psychopharmacology and Biological Psychiatry.
   (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6-
      1982-  Volume(issue)/page/year: 17,151,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 220 mg/kg
SEX/DURATION            : female 11-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 22,43,1991
 
                            *** END OF RECORD ***

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CAS No.78755-81-4 78755-81-4

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CAS No.78755-81-4 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

Assay:99%min Appearance:White Powder Package:1g, 25kg, 200kg or per request depending on different products Storage:Under room temperature away from light Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to airport) or by sea LCL/FCL for large amount. Application:Pharmaceutical intermediates 

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

Assay:98% Appearance:contact us for more details about Flumazenil, CAS:78755-81-4 Package:Glass bottle in aluminum foil bag, from mg scale to kg scale Storage:Seal dark and dry place or contact us for more details Transportation:World wide Courier Service or Air to save your time Application:Chemicals, pharmaceutical research, pharmaceutical intermediates, reagents 

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Amadis Chemical offer CAS#78755-81-4;CAT#A839484

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CAS No.78755-81-4 Flumazenil cas 78755-81-4

Assay:99%min Appearance:white crystalline powder Package:25KG drum Storage:Store in dry, dark and ventilated place Transportation:by air, by sea, by express Application:intermediate 

Min. Order:0

Supplier:Hangzhou Fandachem Co.,Ltd [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:COA Appearance:COA Storage:in stock Application:MSDS/TDS 

Min. Order:0

Supplier:Aecochem Corp. [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please send an equiry Application:For research and development purpose 

Min. Order:0

Supplier:Guangzhou PI & PI Biotech Inc. Ltd. [ China (Mainland)]

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CAS No.78755-81-4 78755-81-4 Flumazenil

Assay:99%MIN Application:78755-81-4 Flumazenil 

Min. Order:0

Supplier:hangzhou quanye maoyi youxiangongsi [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Min. Order:0

Supplier:Suzhou Howsine Biological Technology Co.,Ltd [ China (Mainland)]

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CAS No.78755-81-4 8-?fluoro-?5,?6-?dihydro-?5-?methyl-?6-?oxo-?4H-?imidazo[1,?5-?a][1,?4]benzodiazepine-?3-?carboxylic acid,? ethyl ester

Assay:95% Application:chemical research 

Min. Order:0

Supplier:Angene International Limited [ United Kingdom]

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CAS No.78755-81-4 Flumazenil

Assay:98 Application:R&D 

Min. Order:0

Supplier:Shanghai Send Pharmaceutical Technology Co., Ltd. [ China (Mainland)]

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Address:No.3399 Kangxin Road Pudong District Shanghai,China

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CAS No.78755-81-4 Flumazenil

Assay:Reagents 

Min. Order:0

Supplier:Simson Pharma Limited [ India]

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Address:Near Dahisar Toll Naka

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CAS No.78755-81-4 Flumazenil

Assay:98% Application:API 

Min. Order:0Metric Ton

Supplier:SHANGHAI T&W PHARMACEUTICAL CO., LTD. [ China (Mainland)]

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Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong

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CAS No.78755-81-4 Flumazenil

Assay:98% Application:Pharmaceutical intermediates 

Min. Order:0

Supplier:Jinan Great Chemical Co.,Ltd. [ China (Mainland)]

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Address:No 55,Beixiaoxinzhuang West Street,Jinan City, Shandong Province

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CAS No.78755-81-4 Flumazenil

Assay:CP2010 Application:Medical intermediate; Used in organic synthesis; 

Min. Order:0

Supplier:Skyrun Industrial Co.,Ltd [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:min98% Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and D 

Min. Order:0

Supplier:Shang Hai Grade Biochemical Co,. Limited [ China (Mainland)]

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CAS No.78755-81-4 FluMazenil(Ro 15-1788)

Assay:98% Package:According to the demand of customer Storage:Sealed, dry, microtherm , avoid light and smell. Transportation:by air or by sea Application:Organic synthesis 

Min. Order:0

Supplier:Henan Allgreen Chemical Co.,Ltd [ China (Mainland)]

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