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CAS : 78755-81-4 ProductName : Flumazenil
MSDS  :
 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic
acid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethyl
ester
CAS  
:
 78755-81-4
SYNONYMS  
:
 * Anexate
* Ethyl
8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine
-3-carboxylate
* Flumazenil
* Flumazepil
* Lanexat
* Ro-15-1788

Catalog of Chemical Suppliers, Buyers, Custom Synthesis Companies And Equipment Manufacturers
[ 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylicacid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethylester 78755-81-4 ]
                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : NI2922170
CHEMICAL NAME           : 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic
                          acid, 8-fluoro-5,6-dihydro-5-methyl-6- oxo-, ethyl
                          ester
CAS REGISTRY NUMBER     : 78755-81-4
BEILSTEIN REFERENCE NO. : 4763661
LAST UPDATED            : 199612
DATA ITEMS CITED        : 15
MOLECULAR FORMULA       : C15-H14-F-N3-O3
MOLECULAR WEIGHT        : 303.32
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Anexate
   * Ethyl  
   8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine  
   -3-carboxylate
   * Flumazenil
   * Flumazepil
   * Lanexat
   * Ro-15-1788
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 5700 ng/kg/C
TOXIC EFFECTS :
   Cardiac - cardiomyopathy including infarction
   Cardiac - arrhythmias (including changes in conduction)
   Cardiac - change in rate
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   304,1415,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
   Behavioral - aggression
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 339,488,1992
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 4 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Cardiac - EKG changes not diagnostic of specified effects
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   PECAE5 Pediatric Emergency Care.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1985-  Volume(issue)/page/year: 11,186,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1360 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,402,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 85 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   7,402,1982
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,201,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 143 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >640 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,201,1992
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 23,201,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JTCEEM Journal de Toxicologie Clinique et Experimentale.  (SPPIF, B.P.22,
   F-41353 Vineuil, France) V.5-    1985-  Volume(issue)/page/year: 7,223,1987
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 21 mg/kg
SEX/DURATION            : female 14-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PNPPD7 Progress in Neuro-Psychopharmacology and Biological Psychiatry.
   (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6-
      1982-  Volume(issue)/page/year: 17,151,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 220 mg/kg
SEX/DURATION            : female 11-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   GEPHDP General Pharmacology.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.6-    1975-  Volume(issue)/page/year: 22,43,1991
 
                            *** END OF RECORD ***

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Min. Order:1Kilogram

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CAS No.78755-81-4 78755-81-4 Flumazenil

Assay:鈮?9.0% Appearance:White powder Package:25kg drum/bag Storage:Keep in dry and cool place Transportation:by Sea, air and express Application:銆?Use 1 銆? A nutritional supplement. One of the essential amino acids in the human body. Because the price is higher than DL-methionine and the effect is equal, DL-methionine is often used. 銆?Use  

Min. Order:1Metric Ton

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CAS No.78755-81-4 Flumazenil

Assay:99%min 

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Supplier:Nanjing Finetech Chemical Co., Ltd. [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil cas 78755-81-4

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CAS No.78755-81-4 Flumazenil

Assay:COA Appearance:COA Storage:in stock Application:MSDS/TDS 

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Supplier:Aecochem Corp. [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99% Application:API 

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CAS No.78755-81-4 Flumazenil

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Assay:99% Application:API 

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Supplier:Xian Changyue Biological Technology Co., Ltd. [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99% Application:API 

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Supplier:Hebei Muhuang Technology Co., Ltd [ China (Mainland)]

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Supplier:Wuhan Bright Chemical Co., Ltd. [ China (Mainland)]

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Min. Order:1Kilogram

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Address:Hongshan District

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CAS No.78755-81-4 Flumazenil

Assay:98%min Appearance:white or yellowish white flaky crystal Package:As customer request Storage:Keep the sun from direct sunlight 锛沺revention against high temperature Transportation:By Sea/Air/Courier Application:Used for research and industrial manufacture. 

Min. Order:100Metric Ton

Supplier:Triumph International Development Limilted [ China (Mainland)]

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CAS No.78755-81-4 lower price High quality Flumazenil

Assay:99%min Appearance:white or almost white powder Package:1kg/drum, 25kg/drum, 200kg/drum,500kg/drum Storage:Keep it in dry, cool and ventilated place Transportation:by sea or by air Application: For scientific research 

Min. Order:1Kilogram

Supplier:Shanghai Seasonsgreen Chemical Co.,Ltd [ China (Mainland)]

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Tel:+86 156 1855 4368

Address:No.12, Lane 356, Chengnan Road, Chuansha Town, Shanghai

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CAS No.78755-81-4 USP 99.8% Pure Flumazenil Powder CAS 78755-81-4 Flumazepil Pharmaceutical

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Min. Order:100Gram

Supplier:Wuhan 90000 Lithium Industry and Trade Co., Ltd. [ China (Mainland)]

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CAS No.78755-81-4 Wholesale price CAS 78755-81-4 with fast shipping

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Min. Order:10Kilogram

Supplier:Zhuozhou Wenxi import and Export Co., Ltd [ China (Mainland)]

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CAS No.78755-81-4 cas:78755-81-4 Flumazenil

Assay:99.0%min Appearance:White powder Package:25KG/drum, or according to your requirement Storage:2-8掳C Transportation:by air/ sea/ express Application:raw material 

Min. Order:1Kilogram

Supplier:Wuhan BJM Pharm Inc. [ China (Mainland)]

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Address:No .41 Optics Valley Avenue, East Lake High-tech Development Zone, Wuhan ,China

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CAS No.78755-81-4 Flumazenil

Assay:99% Appearance:liquid or powder  Package:according to the clients requirement Storage:Dry and Cool Place  Transportation:UPS FedEx ,DHL,EXPRESS LINE Application:healing drugs 

Min. Order:1Gram

Supplier:Shandong Mopai Biotechnology Co., LTD [ China (Mainland)]

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Address:shandong

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CAS No.78755-81-4 78755-81-4 Flumazenil

Assay:99% Appearance:white powder Package:drum or based on customers' requirement Storage:normal temperature storage Transportation:by sea, by air Application:We have different specifications for different applications 

Min. Order:1Metric Ton

Supplier:Bluecrystal chem-union [ China (Mainland)]

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CAS No.78755-81-4 lower price 99% Min A white or almost white powder Flumazenil

Assay:99% min Appearance:White or almost white crystalline powder. Package:as required Storage:Stored at well-closed containers  Transportation:by sea by air express Application:used in medicine 

Min. Order:1Kilogram

Supplier:Hangzhou Dawn Ray Pharmaceutical Co.,Ltd [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99% Haccp,,Halal,SC US FDA GMP ISO14001 Appearance:As per Certificate of analysis and our TDS, MSDS Package:Export standard and according to the clients requirement Storage:Store in dry, dark and ventilated place;ISO / Kosher /GMP licence commercial bulk capacity factory in China Transportation:By AIR or by SEA GMP licence / US-FDA,South Korea-KFDA Application:It is an important raw material and intermediate for chemical industry. 

Min. Order:5Kiloliter

Supplier:Chemwill Asia Co., Ltd. [ China (Mainland)]

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Tel:021-51086038

Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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CAS No.78755-81-4 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

Assay:97% Appearance:Powder or liquid Package:According to customer Storage:Store in a tightly closed container, in a cool and dry place. Transportation:Fedex,DHL,TNT,BY SEA and BY AIR Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only. 

Min. Order:10Milligram

Supplier:Amadis Chemical Co., Ltd. [ China (Mainland)]

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CAS No.78755-81-4 High quality API FlumazenilC

Assay:99% Appearance:White Powder Package: according to customers' requirements Storage:Cool Dry Place Transportation:International express delivery Application:Antibiotic and Antimicrobial Agents, Central Nervous System A 

Min. Order:1Gram

Supplier:Baoji Guokang Healthchem co.,ltd [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99% Appearance:Powder Package:Box,Carton,Vials and so on Storage:Cool and dry place Transportation:Air and sea transportation Application:Pharmaceutical Industry 

Min. Order:1Kilogram

Supplier:Qiaoxi District Yitlan electronic business Firm [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99% Min Appearance:white powder Package:1kg/Aluminum foil bag with one plastic-bags inside.10kg/Carton Box with plastic-bags inside.25kg/Paper-drum with two plastic-bags inside. Storage:in sealed air resistant place Transportation:by air, by sea, cargo Application:healing drugs 

Min. Order:1Metric Ton

Supplier:Falcon Life Sciences Pvt. Ltd [ China (Mainland)]

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CAS No.78755-81-4 Acmec Flumazenil F10431 25mg

Assay:Analysis control,HPLC鈮?8% Appearance:See the datasheet Package:25mg Storage:2-8掳C,Dry Transportation:By Express, Air and Road Application:Analytical reagent, biochemical reagent, standard 

Min. Order:1bottle

Supplier:Shanghai Acmec Biochemical Technology Co., Ltd. [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99.3% Appearance:white or Almost colorless Package:2.5kg or 5kg Transportation:Air freight, sea freight, and express delivery Application:intermediate 

Min. Order:4Kilogram

Supplier:SHANGHAI T&W PHARMACEUTICAL CO., LTD. [ China (Mainland)]

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Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong

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Assay:98% Package:According to the customer request Transportation:According to the customer request Application:intermediate of Antimicrobial agent and Antioxidant  

Min. Order:100Gram

Supplier:SHANGHAI SYSTEAM BIOCHEM CO., LTD [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil

Assay:99% Appearance:White Package:5kg/bag Storage:2-8鈩?nbsp;

Min. Order:5Kilogram

Supplier:Hubei Centro pharmaceutical Co., Ltd [ China (Mainland)]

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Address:Room 402, Unit 4, Building 13, Fukang Community, Xinwan Road, Jianghan District, Wuhan City, Hubei, China

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Assay:95-99% Package:10g,100g, 1kg,According to customer Storage:dry and cool Transportation:By air or by courier Application:Chemical raw materials, pharmaceutical intermediates, cosmetic raw materials, etc. 

Min. Order:10Gram

Supplier:TaiChem Taizhou Limited [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil78755-81-4

Assay:99% Package:Grams, Kilograms Storage:Shading, sealed and preserved. Transportation:According to customer request Application:An organic synthetic intermediate used 

Min. Order:0

Supplier:Shandong Jiling Chemical Co., Ltd [ China (Mainland)]

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Address:58 North Industrial Road, Jinan, Shandong, China.

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CAS No.78755-81-4 Flumazenil

Assay:98% Appearance:solid or liquid Package:According to customer鈥榮 requirement Storage:Keep in a cool & dry place Transportation:by sea or air Application:Fine Intermediate 

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Supplier:Xiamen AmoyChem Co.,Ltd [ China (Mainland)]

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Address:Factory 2/F, NO. 206 Weili Road

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CAS No.78755-81-4 78755-81-4 Flumazenil

Assay:98% Appearance:Reference material object Package:According to customer requirements Storage:Sealed and preserved Transportation:By sea or by air Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents 

Min. Order:0

Supplier:Wuhan Newgreat Chemical Co., Ltd [ China (Mainland)]

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Address:East Lake high tech Development Zone, Wuhan, 262, No.

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CAS No.78755-81-4 Flumazenil

Assay:high-purity Appearance:Please feel free to contact us at any time Package:Please communicate with us in a timely manner Storage:Professional storage conditions Transportation:Please communicate with us in a timely manner Application:Applied in the chemical industry 

Min. Order:0

Supplier:Taizhou Longyu Chemical Co., Ltd [ China (Mainland)]

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Address:521 Sanshui Avenue, Jiangyan, Taizhou, Jiangsu

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CAS No.78755-81-4 Flumazenil

Assay:98% Package:As client requirement Transportation:Express, Air , Sea shipment Application:Pharmaceutical Intermediates 

Min. Order:0

Supplier:Hunan chemfish Pharmaceutical co.,Ltd [ China (Mainland)]

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Tel:0731-85567275

Address:Innovation center , Meixi Lake ,Yuelu district ,Changsha City, Hunan Province , China

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CAS No.78755-81-4 Flumazenil (200mg)

Assay:97% Appearance:white to light yellow crystal powder Package:according to the clients requirement Storage:Room temperature with sealed well Transportation:by sea or by air Application:Use as primary and secondary intermediate 

Min. Order:0

Supplier:BOC Sciences [ United States]

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CAS No.78755-81-4 Flumazenil manufacturer

Assay:0.98 Appearance:white powder Package:According client's requirements Storage:keep sealed and keep from direct light Transportation:by express or by sea Application:pharmaceutical 

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Supplier:Shanghai Yuanye Bio-Technology Co., Ltd. [ China (Mainland)]

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Tel:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China

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CAS No.78755-81-4 Flumazenil 78755-81-4

Assay:98% Appearance:solid or liquid Package:Foil bag; Drum; Plastic bottle Storage:in sealed air resistant place Transportation:by sea or air Application:Pharma;Industry;Agricultural 

Min. Order:0

Supplier:Hunan Russell Chemicals Technology Co.,Ltd [ China (Mainland)]

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CAS No.78755-81-4 Flumazenil CAS No.78755-81-4

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CAS No.78755-81-4 Flumazenil 78755-81-4

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Cas no.78755-81-4 98% Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 Flumazenil

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CAS No.78755-81-4 FluMazenil(Ro 15-1788)

Assay:98% Package:According to the demand of customer Storage:Sealed, dry, microtherm , avoid light and smell. Transportation:by air or by sea Application:Organic synthesis 

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