1-Piperidinebutanol, alpha,alpha-diphenyl-

CAS  

 972-02-1

SYNONYMS  

 * Benzhydrol, alpha-(3-piperidinopropyl)-
* Difenidol
* Diphenidol
* alpha,alpha-Diphenyl-1-piperidinebutanol
* Nometic
* SKF 478
* SK&F No. 478-A
* Vontrol

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM4970000
CHEMICAL NAME           : 1-Piperidinebutanol, alpha,alpha-diphenyl-
CAS REGISTRY NUMBER     : 972-02-1
BEILSTEIN REFERENCE NO. : 0265884
REFERENCE               : 5-20-02-00249 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C21-H27-N-O
MOLECULAR WEIGHT        : 309.49
WISWESSER LINE NOTATION : T6NTJ A3XQR&R
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Benzhydrol, alpha-(3-piperidinopropyl)-
   * Difenidol
   * Diphenidol
   * alpha,alpha-Diphenyl-1-piperidinebutanol
   * Nometic
   * SKF 478
   * SK&F No. 478-A
   * Vontrol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 815 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHMCAA Pharmacologist.  (American Soc. for Pharmacology and Experimental
   Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014)  V.1-    1959-
   Volume(issue)/page/year: 5,265,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 304 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHMCAA Pharmacologist.  (American Soc. for Pharmacology and Experimental
   Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014)  V.1-    1959-
   Volume(issue)/page/year: 5,265,1963
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 103 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   LACHDL Liebigs Annalen der Chemie.  (Verlag Chemie International, Inc., VCH
   Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441)  No. 1-    1979-
   Volume(issue)/page/year: (10),1554,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MPHEAE Medicina et Pharmacologia Experimentalis.  (Basel, Switzerland)
   V.12-17, 1965-67.  For publisher information, see PHMGBN.
   Volume(issue)/page/year: 13,325,1965
 
                            *** END OF RECORD ***