|
1.
1.1
IDENTIFICATION
OF
THE
SUBSTANCE/MIXTURE
AND
OF
THE
COMPANY/UNDERTAKING
Product
identifiers
Product
name
Product
Number
Brand
CAS-No.
:
:
:
:
??
-Estradiol
3-sulfate
sodium
salt
E9505
4999-79-5
1.2
Relevant
identified
uses
of
the
substance
or
mixture
and
uses
advised
against
Identified
uses
:
Laboratory
chemicals,
Manufacture
of
substances 2.
2.1
2.2
HAZARDS
IDENTIFICATION
Classification
of
the
substance
or
mixture
Classification
according
to
Regulation
(EC)
No
1272/2008
[EU-GHS/CLP]
Acute
toxicity,
Inhalation
(Category
4)
Acute
toxicity,
Oral
(Category
4)
Carcinogenicity
(Category
2)
Classification
according
to
EU
Directives
67/548/EEC
or
1999/45/EC
Harmful
by
inhalation,
in
contact
with
skin
and
if
swallowed.
Limited
evidence
of
a
carcinogenic
effect.
Label
elements
Labelling
according
Regulation
(EC)
No
1272/2008
[CLP]
Pictogram
Signal
word
Hazard
statement(s)
H302
H332
H351
Precautionary
statement(s)
P281
Supplemental
Hazard
Statements
Warning
Harmful
if
swallowed.
Harmful
if
inhaled.
Suspected
of
causing
cancer.
Use
personal
protective
equipment
as
required.
none
According
to
European
Directive
67/548/EEC
as
amended.
Hazard
symbol(s)
R-phrase(s)
R20/21/22
R40
S-phrase(s)
S22
S36
Harmful
by
inhalation,
in
contact
with
skin
and
if
swallowed.
Limited
evidence
of
a
carcinogenic
effect.
Do
not
breathe
dust.
Wear
suitable
protective
clothing.
2.3
3.
3.2
Other
hazards
-
none
COMPOSITION/INFORMATION
ON
INGREDIENTS
Mixtures
Synonyms
Formula
Molecular
Weight
:
:
:
3,17??
-Dihydroxy-1,3,5(10)-estratriene
3-sulfate
1,3,5(10)-Estratriene-
3,17??
-diol
3-sulfate
C18H23NaO5S
374,43
g/mol
Component
??
-Estradiol
3-sulfate
sodium
salt
Classification
Concentration
CAS-No.
4999-79-5
Acute
Tox.
4;
Carc.
2;
H302,
25
-
50
%
H312,
H332,
H351
Xn,
R20/21/22
-
R40
For
the
full
text
of
the
H-Statements
and
R-Phrases
mentioned
in
this
Section,
see
Section
16
4.
4.1
4.2
4.3
5.
5.1
5.2
FIRST
AID
MEASURES
Description
of
first
aid
measures
General
advice
Consult
a
physician.
Show
this
safety
data
sheet
to
the
doctor
in
attendance.
If
inhaled
If
breathed
in,
move
person
into
fresh
air.
If
not
breathing,
give
artificial
respiration.
Consult
a
physician.
In
case
of
skin
contact
Wash
off
with
soap
and
plenty
of
water.
Consult
a
physician.
In
case
of
eye
contact
Flush
eyes
with
water
as
a
precaution.
If
swallowed
Never
give
anything
by
mouth
to
an
unconscious
person.
Rinse
mouth
with
water.
Consult
a
physician.
Most
important
symptoms
and
effects,
both
acute
and
delayed
To
the
best
of
our
knowledge,
the
chemical,
physical,
and
toxicological
properties
have
not
been
thoroughly
investigated.
(
??
-Estradiol
3-sulfate
sodium
salt)
Indication
of
any
immediate
medical
attention
and
special
treatment
needed
no
data
available
FIREFIGHTING
MEASURES
Extinguishing
media
Suitable
extinguishing
media
Use
water
spray,
alcohol-resistant
foam,
dry
chemical
or
carbon
dioxide.
Special
hazards
arising
from
the
substance
or
mixture
no
data
available
5.3
5.4
6.
6.1
6.2
6.3
6.4
7.
7.1
7.2
7.3
8.
8.1
8.2
Advice
for
firefighters
Wear
self
contained
breathing
apparatus
for
fire
fighting
if
necessary.
Further
information
no
data
available
ACCIDENTAL
RELEASE
MEASURES
Personal
precautions,
protective
equipment
and
emergency
procedures
Use
personal
protective
equipment.
Avoid
dust
formation.
Avoid
breathing
vapors,
mist
or
gas.
Ensure
adequate
ventilation.
Evacuate
personnel
to
safe
areas.
Avoid
breathing
dust.
Environmental
precautions
Prevent
further
leakage
or
spillage
if
safe
to
do
so.
Do
not
let
product
enter
drains.
Methods
and
materials
for
containment
and
cleaning
up
Pick
up
and
arrange
disposal
without
creating
dust.
Sweep
up
and
shovel.
Keep
in
suitable,
closed
containers
for
disposal.
Reference
to
other
sections
For
disposal
see
section
13.
HANDLING
AND
STORAGE
Precautions
for
safe
handling
Avoid
contact
with
skin
and
eyes.
Avoid
formation
of
dust
and
aerosols.
Provide
appropriate
exhaust
ventilation
at
places
where
dust
is
formed.
Conditions
for
safe
storage,
including
any
incompatibilities
Store
in
cool
place.
Keep
container
tightly
closed
in
a
dry
and
well-ventilated
place.
Specific
end
uses
no
data
available
EXPOSURE
CONTROLS/PERSONAL
PROTECTION
Control
parameters
Components
with
workplace
control
parameters
Exposure
controls
Appropriate
engineering
controls
Handle
in
accordance
with
good
industrial
hygiene
and
safety
practice.
Wash
hands
before
breaks
and
at
the
end
of
workday.
Personal
protective
equipment
Eye/face
protection
Safety
glasses
with
side-shields
conforming
to
EN166
Use
equipment
for
eye
protection
tested
and
approved
under
appropriate
government
standards
such
as
NIOSH
(US)
or
EN
166(EU).
Skin
protection
Handle
with
gloves.
Gloves
must
be
inspected
prior
to
use.
Use
proper
glove
removal
technique
(without
touching
glove's
outer
surface)
to
avoid
skin
contact
with
this
product.
Dispose
of
contaminated
gloves
after
use
in
accordance
with
applicable
laws
and
good
laboratory
practices.
Wash
and
dry
hands.
The
selected
protective
gloves
have
to
satisfy
the
specifications
of
EU
Directive
89/686/EEC
and
the
standard
EN
374
derived
from
it.
Body
Protection
Complete
suit
protecting
against
chemicals,
The
type
of
protective
equipment
must
be
selected
according
to
the
concentration
and
amount
of
the
dangerous
substance
at
the
specific
workplace.
Respiratory
protection
Where
risk
assessment
shows
air-purifying
respirators
are
appropriate
use
a
full-face
particle
respirator
type
N100
(US)
or
type
P3
(EN
143)
respirator
cartridges
as
a
backup
to
engineering
controls.
If
the
respirator
is
the
sole
means
of
protection,
use
a
full-face
supplied
air
respirator.
Use
respirators
and
components
tested
and
approved
under
appropriate
government
standards
such
as
NIOSH
(US)
or
CEN
(EU).
9.
9.1
PHYSICAL
AND
CHEMICAL
PROPERTIES
Information
on
basic
physical
and
chemical
properties
a)
b)
c)
d)
e)
f)
g)
h)
Appearance
Odour
Odour
Threshold
pH
Melting
point/freezing
point
Initial
boiling
point
and
boiling
range
Flash
point
Evaporation
rate
Form:
solid
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
i)
Flammability
(solid,
gas)
no
data
available
j)
k)
l)
Upper/lower
flammability
or
explosive
limits
Vapour
pressure
Vapour
density
no
data
available
no
data
available
no
data
available
m)
Relative
density
no
data
available
n)
o)
p)
q)
r)
s)
t)
Water
solubility
Partition
coefficient:
n-
octanol/water
Autoignition
temperature
Decomposition
temperature
Viscosity
Explosive
properties
Oxidizing
properties
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
9.2
10.
10.1
10.2
10.3
10.4
10.5
Other
safety
information
no
data
available
STABILITY
AND
REACTIVITY
Reactivity
no
data
available
Chemical
stability
no
data
available
Contains
the
following
stabiliser(s):
Meglumine
(70
%)
Possibility
of
hazardous
reactions
no
data
available
Conditions
to
avoid
no
data
available
Incompatible
materials
no
data
available
10.6
11.
11.1
Hazardous
decomposition
products
Other
decomposition
products
-
no
data
available
TOXICOLOGICAL
INFORMATION
Information
on
toxicological
effects
Acute
toxicity
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Skin
corrosion/irritation
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Serious
eye
damage/eye
irritation
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Respiratory
or
skin
sensitization
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Germ
cell
mutagenicity
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Carcinogenicity
(
??
-Estradiol
3-sulfate
sodium
salt)
Limited
evidence
of
carcinogenicity
in
animal
studies
(
??
-Estradiol
3-sulfate
sodium
salt)
(
??
-Estradiol
3-sulfate
sodium
salt)
IARC:
No
component
of
this
product
present
at
levels
greater
than
or
equal
to
0.1%
is
identified
as
probable,
possible
or
confirmed
human
carcinogen
by
IARC.
Reproductive
toxicity
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Overexposure
may
cause
reproductive
disorder(s)
based
on
tests
with
laboratory
animals.
(
??
-Estradiol
3-
sulfate
sodium
salt)
Specific
target
organ
toxicity
-
single
exposure
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Specific
target
organ
toxicity
-
repeated
exposure
no
data
available
Aspiration
hazard
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Potential
health
effects
Inhalation
Ingestion
Skin
Eyes
Harmful
if
inhaled.
May
cause
respiratory
tract
irritation.
Harmful
if
swallowed.
May
be
harmful
if
absorbed
through
skin.
May
cause
skin
irritation.
May
cause
eye
irritation.
Signs
and
Symptoms
of
Exposure
To
the
best
of
our
knowledge,
the
chemical,
physical,
and
toxicological
properties
have
not
been
thoroughly
investigated.
(
??
-Estradiol
3-sulfate
sodium
salt)
Additional
Information
RTECS:
Not
available
12.
12.1
12.2
ECOLOGICAL
INFORMATION
Toxicity
no
data
available
Persistence
and
degradability
no
data
available
12.3
12.4
12.5
12.6
13.
13.1
14.
14.1
Bioaccumulative
potential
no
data
available
Mobility
in
soil
no
data
available
(
??
-Estradiol
3-sulfate
sodium
salt)
Results
of
PBT
and
vPvB
assessment
no
data
available
Other
adverse
effects
no
data
available
DISPOSAL
CONSIDERATIONS
Waste
treatment
methods
Product
Offer
surplus
and
non-recyclable
solutions
to
a
licensed
disposal
company.
Dissolve
or
mix
the
material
with
a
combustible
solvent
and
burn
in
a
chemical
incinerator
equipped
with
an
afterburner
and
scrubber.
Contaminated
packaging
Dispose
of
as
unused
product.
TRANSPORT
INFORMATION
UN
number
14.2
14.3
14.4
14.5
14.6
15.
ADR/RID:
-
UN
proper
shipping
name
ADR/RID:
Not
dangerous
goods
IMDG:
Not
dangerous
goods
IATA:
Not
dangerous
goods
Transport
hazard
class(es)
ADR/RID:
-
Packaging
group
ADR/RID:
-
Environmental
hazards
ADR/RID:
no
Special
precautions
for
user
no
data
available
REGULATORY
INFORMATION
IMDG:
-
IMDG:
-
IMDG:
-
IMDG
Marine
pollutant:
no
IATA:
-
IATA:
-
IATA:
-
IATA:
no
This
safety
datasheet
complies
with
the
requirements
of
Regulation
(EC)
No.
1907/2006.
15.1
15.2
16.
Safety,
health
and
environmental
regulations/legislation
specific
for
the
substance
or
mixture
no
data
available
Chemical
Safety
Assessment
no
data
available
OTHER
INFORMATION
Text
of
H-code(s)
and
R-phrase(s)
mentioned
in
Section
3
Acute
Tox.
Carc.
H302
H312
H332
H351
Xn
R20/21/22
R40
Acute
toxicity
Carcinogenicity
Harmful
if
swallowed.
Harmful
in
contact
with
skin.
Harmful
if
inhaled.
Suspected
of
causing
cancer.
Harmful
Harmful
by
inhalation,
in
contact
with
skin
and
if
swallowed.
Limited
evidence
of
a
carcinogenic
effect.
Further
information
The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.
| 
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL 3-SULFATE SODIUM SALT
China (Mainland)] 
Assessed
Assessed
Assessed
Assessed
Assessed
Assessed
Assessed
Premium
United States] 
Premium
Premium
Premium
Premium