1 - Product and Company Information

Product Name TRIGLYCERIDE REAGENT
Product Number T2449
Brand SIGMA

Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052

Section 2 - Composition/Information on Ingredient

Substance Name CAS # SARA 313
TRIGLYCERIDE (GPO-TRINDER) REAGENT None Yes
B

Ingredient Name CAS # Percent SARA 313
The hazards identified with this None
product are those associated with the
following component(s):
D(-)-MANNITOL, 69-65-8 >= 69.364 No
<= 84.656
SODIUM AZIDE 26628-22-8 2.4387 Yes
LIPOPROTEIN LIPASE 9004-02-8 >= 13.227 No
<= 28.901

Section 3 - Hazards Identification

EMERGENCY OVERVIEW
Highly Toxic (USA) Toxic (EU).
Heating may cause an explosion. Toxic by inhalation, in contact
with skin and if swallowed. Contact with acids liberates very
toxic gas. Harmful to aquatic organisms, may cause long-term
adverse effects in the aquatic environment.
Readily absorbed through skin. Sodium azide may react with lead
and copper plumbing to form highly explosive metal azides. Target
organ(s): Nerves. Heart.

HMIS RATING
HEALTH: 3*
FLAMMABILITY: 0
REACTIVITY: 2

NFPA RATING
HEALTH: 3
FLAMMABILITY: 0
REACTIVITY: 2

*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.

Section 4 - First Aid Measures

ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.

INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.

DERMAL EXPOSURE
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.

EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.

Section 5 - Fire Fighting Measures

EXPLOSION HAZARDS
Container explosion may occur under fire conditions. Azide
reacts with many heavy metals such as lead, copper, mercury,
silver, gold to form explosive compounds. Copper and lead azides
are more sensitive than nitroglycerine. Azide reacts with metal
halides to give a range of metal azide halides, many of which
are explosive. Incompatible with chromyl chloride, hydrazine,
bromine, carbon disulfide, dimethyl sulfate, dibromomalonitrile.
An explosion occurred when a mixture of sodium azide, methylene
chloride, dimethyl sulfoxide, and sulfuric acid were being
concentrated on a rotary evaporator.

FLASH POINT
N/A

AUTOIGNITION TEMP
N/A

FLAMMABILITY
N/A

EXTINGUISHING MEDIA
Suitable: Dry chemical powder.
Unsuitable: Do not use water.

FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.

Section 6 - Accidental Release Measures

PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.


SIGMA - T2449 www.-aldrich.com METHODS FOR CLEANING UP
Spilled material should be carefully wiped up or moistened with
water and removed. Ventilate area and wash spill site after
material pickup is complete.

Section 7 - Handling and Storage

HANDLING
User Exposure: Avoid inhalation. Avoid contact with eyes, skin,
and clothing. Avoid prolonged or repeated exposure.

STORAGE
Suitable: Keep tightly closed. Store away from heat.
Incompatible Materials: Azide reacts with many heavy metals such
as lead, copper, mercury, silver, gold to form explosive
compounds. Copper and lead azides are more sensitive than
nitroglycerine. Azide reacts with metal halides to give a range
of metal azide halides, many of which are explosive.
Incompatible with chromyl chloride, hydrazine, bromine, carbon
disulfide, dimethyl sulfate, dibromomalonitrile.
Store at 2-8?C

SPECIAL REQUIREMENTS
Heat sensitive.

Section 8 - Exposure Controls / PPE

ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.

PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.

GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.

Section 9 - Physical/Chemical Properties

Appearance Physical State: Solid

Property Value At Temperature or Pressure

Molecular Weight N/A
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A


SIGMA - T2449 www.-aldrich.com Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A

N/A = not available

Section 10 - Stability and Reactivity

STABILITY
Stable: Stable.
Conditions of Instability: Heat sensitive. May explode when heated.
Materials to Avoid: Halogenated solvents Avoid contact with
metals. Avoid contact with acid., Acid chlorides

HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Nitrogen oxides, Sodium oxides.

HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

Section 11 - Toxicological Information

ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Toxic if absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Toxic if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Toxic if swallowed.

TARGET ORGAN(S) OR SYSTEM(S)
Nerves. Heart. Brain.

SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, headache, and vomiting. Laboratory
experiments in animals have shown sodium azide to produce a
profound hypotensive effect, demyelination of myelinated nerve
fibers in the central nervous system, testicular damage,
blindness, attacks of rigidity, and hepatic and cerebral effects.

CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.

Section 12 - Ecological Information

No data available.

Section 13 - Disposal Considerations

APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.


SIGMA - T2449 www.-aldrich.com Section 14 - Transport Information

DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.

IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.

Section 15 - Regulatory Information

EU ADDITIONAL CLASSIFICATION
Symbol of Danger: T
Indication of Danger: Toxic.
R: 5 23/24/25 32 52/53
Risk Statements: Heating may cause an explosion. Toxic by
inhalation, in contact with skin and if swallowed. Contact with
acids liberates very toxic gas. Harmful to aquatic organisms,
may cause long-term adverse effects in the aquatic environment.
S: 7/9 28 36/37 45
Safety Statements: Keep container tightly closed and in
well-ventilated place. After contact with skin, wash immediately
with plenty of soap-suds. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).

US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Toxic (EU).
Risk Statements: Heating may cause an explosion. Toxic by
inhalation, in contact with skin and if swallowed. Contact with
acids liberates very toxic gas. Harmful to aquatic organisms,
may cause long-term adverse effects in the aquatic environment.
Safety Statements: Keep container tightly closed and in
well-ventilated place. After contact with skin, wash immediately
with plenty of soap-suds. Wear suitable protective clothing and
gloves. In case of accident or if you feel unwell, seek medical
advice immediately (show the label where possible).
US Statements: Readily absorbed through skin. Sodium azide may
react with lead and copper plumbing to form highly explosive
metal azides. Target organ(s): Nerves. Heart.

UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is or contains a component that is subject
to SARA313 reporting requirements.

CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No

Section 16 - Other Information

DISCLAIME For R&D use only. Not for drug, household or other uses.

WARRANTY


SIGMA - T2449 www.-aldrich.com  The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.




SIGMA - T2449 www.-aldrich.com 

LIPOPROTEIN LIPASE