Material Safety Data Sheet
Catalog Number: 320221
Revision date: 25-Apr-2006


1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY INFORMATION

Catalog Number: 320221

Product name: CHONDROITINASE AC-II LYASE

Supplier:
MP Biomedicals, LLC
29525 Fountain Parkway
Solon, OH 44139
tel: 440-337-1200

Emergency telephone number: CHEMTREC: 1-800-424-9300 (1-703-527-3887)

2. COMPOSITION/INFORMATION ON INGREDIENTS


Components CAS Number Weight % ACGIH Exposure Limits: OSHA Exposure Limits:
CHONDROITINASE AC-II LYASE 9047-57-8 90 - 100% None None


3. HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW: May cause skin irritation and/or dermatitis



Principle routes of exposure: Skin
Inhalation: May cause irritation of respiratory tract
Ingestion: May be harmful if swallowed.
Skin contact: May cause allergic skin reaction
Eye contact: Avoid contact with eyes

Statements of hazard MAY CAUSE ALLERGIC SKIN REACTION.
Statement of Spill or Leak - ANSI Label Eliminate all ignition sources. Absorb and/or contain spill with inert materials
(e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush
spill area. Prevent runoff from entering waterways or sewers.

4. FIRST AID MEASURES

General advice: In the case of accident or if you feel unwell, seek medical advice immediately (show the label where
possible).
Inhalation: Move to fresh air. Call a physician immediately.
Skin contact: Rinse immediately with plenty of water and seek medical advice
Ingestion: Do not induce vomiting without medical advice.
Eye contact: In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Protection of first-aiders: No information available
Medical conditions aggravated by exposure: None known



Catalog Number: 320221 Product name: CHONDROITINASE AC-II LYASE MP Biomedicals, LLC www.mpbio.com


5. FIRE FIGHTING MEASURES

Suitable extinguishing media: Use dry chemical, CO2, water spray or "alcohol" foam
Specific hazards: Burning produces irritant fumes.
Unusual hazards: None known
Special protective equipment for firefighters: As in any fire, wear self-contained breathing apparatus
pressure-demand, MSHA/NIOSH (approved or equivalent)
and full protective gear
Specific methods: Water mist may be used to cool closed containers.
Flash point: Not determined
Autoignition temperature: Not determined
NFPA rating:
NFPA Health: 1
NFPA Flammability: 1
NFPA Reactivity: 0

6. ACCIDENTAL RELEASE MEASURES

Personal precautions: Use personal protective equipment.
Environmental precautions: Prevent product from entering drains.
Methods for cleaning up: Sweep up and shovel into suitable containers for disposal.

7. HANDLING AND STORAGE

Storage:
-20??C

Handling: Use only in area provided with appropriate exhaust
ventilation.
Safe handling advice: Wear personal protective equipment.
Incompatible products: Oxidising and spontaneously flammable products

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

Engineering measures: Ensure adequate ventilation.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory protection: Breathing apparatus only if aerosol or dust is formed.
Hand protection: Pvc or other plastic material gloves
Skin and body protection: Usual safety precautions while handling the product will provide adequate protection against
this potential effect.
Eye protection: Safety glasses with side-shields
Hygiene measures: Handle in accordance with good industrial hygiene and safety practice.




9. PHYSICAL AND CHEMICAL PROPERTIES

Formula: Not applicable
Melting point/range: No data available at this time.
Boiling point/range: No Data available at this time.
Density: No data available
Vapor pressure: No data available
Evaporation rate: No data available
Vapor density: No data available
Solubility (in water): No data available
Catalog Number: 320221 Product name: CHONDROITINASE AC-II LYASE MP Biomedicals, LLC www.mpbio.com

Flash point: Not determined
Autoignition temperature: Not determined

10. STABILITY AND REACTIVITY

Stability: Stable under recommended storage conditions.
Polymerization: None under normal processing.
Hazardous decomposition products: Thermal decomposition can lead to release of irritating
gases and vapours such as carbon oxides.
Materials to avoid: Strong oxidising agents
Conditions to avoid: Exposure to air or moisture over prolonged periods.

11. TOXICOLOGICAL INFORMATION

Product Information
Acute toxicity
Components RTECS Number: Selected LD50s and LC50s
CHONDROITINASE AC-II LYASE Not Available Not Determined

Chronic toxicity: Chronic exposure may cause nausea and vomiting, higher exposure causes
unconsciousness.
Local effects: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and
vomiting.
Specific effects: May include moderate to severe erythema (redness) and moderate edema (raised
skin), nausea, vomiting, headache.
Primary irritation: No data is available on the product itself.
Carcinogenic effects: No data is available on the product itself.
Mutagenic effects: No data is available on the product itself.
Reproductive toxicity: No data is available on the product itself.

12. ECOLOGICAL INFORMATION

Mobility: No data available
Bioaccumulation: No data available
Ecotoxicity effects: No data available
Aquatic toxicity: May cause long-term adverse effects in the aquatic
environment.

Components U.S. DOT - Appendix B - U.S. DOT - Appendix B - United Kingdom - The Red
Marine Pollutan Severe Marine Pollutants List:
CHONDROITINASE AC-II LYASE Not Listed Not Listed Not Listed

Components Germany VCI (WGK) World Health Organization Ecotoxicity - Fish Species
(WHO) - Drinking Water Data
CHONDROITINASE AC-II LYASE Not Listed Not Listed Not Listed

Components Ecotoxicity - Freshwater Ecotoxicity - Microtox Data Ecotoxicity - Water Flea
Algae Data Data
CHONDROITINASE AC-II LYASE Not Listed Not Listed Not Listed

Components EPA - ATSDR Priority List EPA - HPV Challenge California - Priority Toxic
Program Chemical List Pollutants
CHONDROITINASE AC-II LYASE Not Listed Not Listed Not Listed



Catalog Number: 320221 Product name: CHONDROITINASE AC-II LYASE MP Biomedicals, LLC www.mpbio.com

Components California - Priority Toxic Pollutants California - Priority Toxic Pollutants
CHONDROITINASE AC-II LYASE Not Listed Not Listed

13. DISPOSAL CONSIDERATIONS

Waste from residues / unused products: Waste disposal must be in accordance with appropriate
Federal, State, and local regulations. This product, if
unaltered by use, may be disposed of by treatment at a
permitted facility or as advised by your local hazardous
waste regulatory authority. Residue from fires extinguished
with this material may be hazardous.
Contaminated packaging: Do not re-use empty containers

14. TRANSPORT INFORMATION

UN/Id No: Not regulated

DOT:
Proper shipping name: Not Regulated


Components U.S. DOT - Appendix A Table 1 - Reportable Quantities
CHONDROITINASE AC-II LYASE Not Listed



TDG (Canada):
WHMIS hazard class: Non-controlled

IMDG/IMO

IMDG - Hazard Classifications Not Applicable

Components U.S. DOT - Appendix B - Marine Pollutan U.S. DOT - Appendix B - Severe Marine
Pollutants
CHONDROITINASE AC-II LYASE Not Listed Not Listed



IMO-labels:

15. REGULATORY INFORMATION

International Inventories

Components
CHONDROITINASE AC-II LYASE
Inventory - United States TSCA - Sect. 8(b) Not Listed
Canada DSL Inventory List - Not Listed

U.S. regulations:




Catalog Number: 320221 Product name: CHONDROITINASE AC-II LYASE MP Biomedicals, LLC www.mpbio.com

California Proposition 65 Massachusetts Right to New Jersey Right to Pennsylvania Right to Know
Components
- Know List: Know List: List:
Not Listed Not Listed Not Listed Not Listed
CHONDROITINASE AC-II
LYASE

Florida substance List: Rhode Island Right to Illinois - Toxic Air Connecticut - Hazardous Air
Components
Know List: Contaminants Pollutants
Not Listed Not Listed Not Listed Not Listed
CHONDROITINASE AC-II
LYASE

SARA 313 Emission CERCLA/SARA - Section NTP: IARC:
Components
reporting/Toxic Release 302 Extremely Haz
of Chemicals
Not Listed Not Listed None None
CHONDROITINASE AC-II
LYASE

SARA 313 Notification: The above is your notification as to the SARA 313 listing for this product(s) pursuant
to Section 313 of Title III of the Superfund Ammendments and Reauthorization Act of
1986 and 40 CFR Part 372.

If you are unsure if you are subject to the reporting requirements of Section 313, or
need more information, please call the EPA Emergency Planning and Community
Right-To-Know Information Hotline: (800) 535-0202 or (202) 479-2499 (in
Washington, DC or Alaska).

State Notification: The above information is your notice as to the Right-to-Know listings of the stated
product(s). Individual states will list chemicals for a variety of reasons including, but
not limited to, the compounds toxicity; carcinogenic, tumorigenic and/or reproductive
hazards; and the compounds environmental impact if accidentally released.

16. OTHER INFORMATION

Prepared by: Health & Safety
Disclaimer: The information and recommendations contained herein are based upon tests believed to be reliable.
However, MP Biomedicals does not guarantee the accuracy or completeness NOR SHALL ANY OF THIS
INFORMATION CONSTITUTE A WARRANTY, WHETHER EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE
GOODS, THE MERCHANTABILITY OF THE GOODS, OR THE FITNESS OF THE GOODS FOR A PARTICULA PURPOSE. Adjustment to conform to actual conditions of usage maybe required. MP Biomedicals assumes no
responsibility for results obtained or for incidental or consequential damages, including lost profits arising from the use of
these data. No warranty against infringement of any patent, copyright or trademark is made or implied.
End of Safety Data Sheet




Catalog Number: 320221 Product name: CHONDROITINASE AC-II LYASE 

CHONDROITIN AC LYASE