*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : NI3505000
CHEMICAL NAME : Imidazole, 4-aminoethyl-, hydrochloride
CAS REGISTRY NUMBER : 55-36-7
LAST UPDATED : 199706
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C5-H9-N3.xCl-H
MOLECULAR WEIGHT : 366.39
WISWESSER LINE NOTATION : T5M CNJ D2Z &GH
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* Chlorhydrate d'histamine
* Histamine, monohydrochloride
* 1H-Imidazole-4-ethanamine, monohydrochloride
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 230 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1875 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory
change
Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 12 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intracerebral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 865 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraarterial
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 170 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 1498 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 1364 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 2273 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZIETA2 Zeitschrift fuer Immunitaetsforschung und Experimentelle Therapie.
(Stuttgart, Fed. Rep. Ger.) 1924-62. For publisher information, see
ZIEKBA. Volume(issue)/page/year: 60,222,1929
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1140 mg/kg/28W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Gastrointestinal - tumors
REFERENCE :
BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer. (Paris,
France) V.1-52, 1908-65. For publisher information, see BUCABS.
Volume(issue)/page/year: 36,305,1949
*** END OF RECORD ***
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