MATERIAL SAFETY DATA SHEET


ALSAN 500
Disponible en fran?ais
WHMIS PROTECTIVE CLOTHING TRANSPORT OF DANGEROUS GOODS
PAINT
Class 3
UN1263
P.G.: II

SECTION I. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

Product name: Alsan 500
Use: Mono-component waterproofing polyurethane resin.

Code of MSDS: CA U DRU SS FS 007
Formula number: 545.1
Revision date: December 13, 2007
Revised by: Michel Galtier, Health and Safety Supervisor
(800) 567-1492
mgaltier@soprema.ca
Manufacturer: Soprema Canada
1675 Haggerty Street
Drummondville (Quebec) J2C 5P7
CANADA
Tel.: (819) 478-8163
Distributors: Soprema Inc. Soprema 44955 Yale Road West 310, Quadral Drive
Chilliwack (BC) V2R 2H3 Wadsworth (Ohio) 44281
CANADA UNITED STATES
Tel.: (604) 793-7100 Tel.: (800) 356-3521

In case of emergency:
SOPREMA (8:00am to 5:00pm ?? Eastern time): (800) 567-1492
CANUTEC (Canada) (24h.): (613) 996-6666
CHEMTREC (USA) (24h.): (800) 424-9300
Poison Control Centre: Consult local telephone directory




EMERGENCY OVERVIEW!!!
Caution! This product and its vapours are highly flammable. Vapour is heavier than air and may spread long distances. Distant
ignition and flash back are possible.
May cause irritation to eyes, skin and respiratory tract. High vapour concentrations may cause depression of central nervous
system. This product contains isocyanates. May cause sensitization by inhalation and by contact with skin. Irritating and/or toxic
gases or fumes may be generated by thermal decomposition or combustion.




Alsan 500 Revision date: December 13, 2007  SECTION II. COMPOSITION AND INFORMATION ON DANGEROUS INGREDIENTS
EXPOSURE LIMIT
NAME CAS # % WEIGHT
(ACGIH)
TLV-TWA TLV-STEL
Propylene Glycol Methylethyl Acetate
108-65-6 7-13 50 ppm Not established
(PGMEA)
108-88-3 7-13 20 ppm Not established
Toluene
26471-62-5 5-10 (to confirm) 0.005 ppm 0.02 ppm
Toluene Diisocyanate (TDI)
78-93-3 3-7 200 ppm 300 ppm
Methyl Ethyl Ketone (MEK)
Carbamic acid, 1,6-hexanediylbis-, bis [2-[2-
59719-67-4 1-5 Not established Not established
(1-methylethyl)-3-oxazolidinyl]ethyl] ester
1305-78-8 0.5-1.5 2 mg/m3 Not established
Calcium Oxide
26523-78-4 0.5-1.5 Not established Not established
Tris(nonylphenyl)phosphite
3.5 mg/m3
1333-86-4 0.1-1 Not established
Carbon Black
(breathable dust)
133-07-3 0.1-1 Not established Not established
N-(trichloromethylthio)phthalimide
98-88-4 0.1-1 0.5 ppm 1 ppm
Benzoyl Chloride
4083-64-1 0.1-1 Not established Not established
Para toluenesulfonyl Isocyanate

SECTION III. POTENTIAL HEALTH EFFECTS
Effects of Short-Term (Acute) Exposure
INHALATION:
Inhalation of vapours of MEK, PGMEA and isocyanates (TDI) can occur. The exposition to vapours of solvents such as MEK over
exposure limits may cause irritation of the respiratory system and central nervous system depression (headaches, dizziness, nausea,
tiredness, confusion and coma). TDI is a sensitizer and may cause severe allergic reaction (e.g. asthma, difficulty to breath, angina).
Repeated exposures can lead to permanent respiratory disorders.
PGMEA: PGMEA is not expected to cause any effects based on the low concentration level of this chemical in the product. Based on the
effect of the chemically-similar propylene glycol monomethyl ether (PGME), irritation of the nose and throat from inhalation of propylene
glycol monomethyl ether acetate (PGMEA) vapour or mist would be expected. (1)
Toluene: The main effect of inhaling toluene vapour is on the central nervous system (CNS). Symptoms are related to exposure
concentration. At approximately 50 ppm, slight drowsiness and headache have been reported. Irritation of the nose, throat and respiratory
tract has occurred between 50 and 100 ppm. Concentrations of about 100 ppm have caused fatigue and dizziness; over 200 ppm have
caused symptoms similar to drunkenness (giddiness), numbness, and mild nausea; over 500 ppm have caused mental confusion and
incoordination. (1)
TDI: Short-term exposure to isocyanates, such as toluene diisocyanate (TDI), can cause respiratory and mucous membrane irritation at
vapour levels of 0.05 ppm and above. Symptoms include eye and nose irritation, dry or sore or burning throat, runny nose, shortness of
breath, wheezing and laryngitis. Coughing with chest pain or tightness may also occur, frequently at night. These symptoms may occur
during exposure or may be delayed for several hours. High exposures could cause inflammation of the lung tissue (chemical pneumonitis),
chemical bronchitis with severe asthma-like wheezing, severe coughing spasms and accumulation of fluid in the lungs (pulmonary
oedema), which could prove fatal. Symptoms of pulmonary oedema may not appear until several hours after exposure and are aggravated
by physical exertion. Effects such as euphoria, muscle incoordination and loss of consciousness have been reported after a single severe
exposure to TDI. Headache, difficulty in concentration, poor memory and confusion may persist for up to 4 years. (1)
MEK: Brief (3-5 minutes) exposures to methyl ethyl ketone (MEK) vapours produced slight nose and throat irritation at 100 ppm and
definite nose and throat irritation at 350 ppm in approximately 10 people. 143 volunteers exposed to 200 ppm for 4 hours reported throat
irritation, unpleasant odour, nausea, and headache (in order of frequency reported). Higher exposures are expected to cause central nervous
system depression with symptoms such as headache, nausea, dizziness, drowsiness, and confusion. Extremely high concentrations may
cause loss of consciousness and possibly death. Neurobehavioral effects of exposures to MEK (200 ppm for 4 hours) were studied with
137 volunteers. There were no statistically significant effects observed in biochemical, psychomotor, sensorimotor and psychological tests.
Similar findings have been reported in other studies. Four volunteers were exposed to 90 to 270 ppm MEK for 4 hours/day for 4 days.
Minor disturbances in time perception were observed. (1)
Carbamic acid, 1,6-hexanediylbis-, bis [2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] ester: Harmful, and may cause sensitization by
inhalation. Based on the available properties of the isocyanate content of this product, respiratory exposure may cause acute irritation
and/or sensitization of the respiratory system, resulting in asthmatic symptoms, wheezing and a tightness of the chest. Sensitized persons
may subsequently show asthmatic symptoms when exposed to airborne concentrations of isocyanates well below the occupational
exposure limit. Repeated exposure may lead to permanent respiratory disability. Exposure to organic vapours may result in adverse health
effects, especially when used in confined / unventilated areas, such as irritation of the mucous membrane and the respiratory system and
adverse effects on the renal and central nervous systems. Symptoms include headache, dizziness, fatigue, muscular weakness, drowsiness
and in extreme cases loss of consciousness. (2)

Alsan 500 Revision date: December 13, 2007  SECTION III. POTENTIAL HEALTH EFFECTS
INHALATION: (continued)
Carbon black: Carbon black does not appear to cause significant harmful effects after a single short-term exposure, except general effects
that would be expected with any dust (high concentrations can cause coughing and mild, temporary irritation). (1)
N-(trichloromethylthio)phthalimide: May be fatal if inhaled. (2)
Para toluenesulfonyl Isocyanate: Isocyanate vapour/mists at concentration above the exposure limits can irritate (burning sensation) the
mucous membranes in the respiratory tract. May cause sensitization by inhalation. (2)
SKIN CONTACT:
Frequent or prolonged contacts can remove the natural fat from the skin and may cause redness, skin irritation and dermatitis. TDI is a
sensitizer and may cause severe allergic reaction (e.g. eczema). MEK can be absorbed through the skin. (1)
TDI: Liquid TDI produces a marked inflammatory reaction. Prolonged or further contact can cause severe inflammation, redness, rash,
swelling, blistering and burns. Isocyanates, in general, can cause skin discolouration (staining) and hardening of the skin after repeated
exposures. Skin contact is not expected to result in the absorption of harmful amounts. Skin sensitization may occur in some individuals,
but it is not common. TDI vapour and aerosols may also cause skin irritation. Usually, this only happens at levels higher than those that
cause respiratory effects. (1)
Carbamic acid, 1,6-hexanediylbis-, bis [2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] ester: May cause sensitization by skin contact. (2)
Tris(nonylphenyl)phosphite: Causes skin irritation. (2)
Carbon Black: Carbon black is not irritating to the skin. (1)
N-(trichloromethylthio)phthalimide: May cause allergic skin reaction. (2)
Benzoyl Chloride: Benzoyl chloride is corrosive to skin based on animal information and because it reacts violently with moisture to
produce heat, benzoic acid and hydrogen chloride gas, and with air to form corrosive fumes. Corrosive materials are capable of producing
severe burns, blisters, ulcers and permanent scarring, depending on the concentration of the solution and the duration of contact. No human
information was located. (1)
Para toluenesulfonyl Isocyanate: Skin irritant. (2)
EYE CONTACT:
Vapours or eye contact may cause eye irritation, redness and pain.
TDI: Liquid TDI can cause watering of the eyes, severe irritation and possible clouding of the cornea. Exposure to high TDI vapour
concentration can lead to formation of solid particles in the eye fluid which can cause mechanical irritation hours after exposure. (1)
Carbamic acid, 1,6-hexanediylbis-, bis [2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] ester: May cause irritation. (2)
Tris(nonylphenyl)phosphite: May cause eye irritation. (2)
Carbon Black: Carbon black dust is not irritating to the eyes except as a ??foreign object??. (1)
N-(trichloromethylthio)phthalimide: Causes severe eye irritation. May cause tissue damage. (2)
Benzoyl Chloride: Benzoyl chloride is corrosive to eyes based on animal information and because it reacts violently with moisture to
produce heat, benzoic acid and hydrogen chloride gas, and with air to form corrosive fumes. Corrosive materials are capable of producing
severe eye burns, and permanent injury, including blindness, depending on the concentration of the solutions and duration of contact. No
human information was located. (1)
Para toluenesulfonyl Isocyanate: Contact with eyes can cause severe damage. (2)
INGESTION:
It is unlikely that toxic amounts of this product would be ingested with normal handling and use. If significant amount of the product were
ingested, symptoms as described for inhalation might occur. This product may cause irritation, mouth and throat burns and abdominal
pains.
TDI: TDI is not expected to be toxic if ingested based on animal toxicity values. Swallowing TDI could cause irritation and corrosion of
the tissues lining the mouth, throat and stomach. Ingestion is not a typical route of occupational exposure. (1)
Carbamic acid, 1,6-hexanediylbis-, bis [2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] ester: May cause discomfort and risk of lung damage
if vomiting results. (2)
N-(trichloromethylthio)phthalimide: Not a hazard under normal use conditions. (2)
Para toluenesulfonyl isocyanate: May cause severe irritation of the mouth, oesophagus and stomach. (2)
Effects of Long-Term (Chronic) Exposure
INHALATION:
Carbon black: Carbon black dust is extremely fine and light and can be breathed deeply into the lungs, where it can accumulate. Normally
the dust is cleared gradually from the lungs an has no harmful effects. However, high concentrations of dust can overwhelm the clearance
capacity of the lungs, obstruct the lungs, and interfere with lung function. Symptoms may include coughing, increased phlegm production,
and shortness of breath. It is unlikely that toxic amounts of this product would be ingested with normal handling and use. (1)
Alsan 500 Revision date: December 13, 2007  SECTION III. POTENTIAL HEALTH EFFECTS
RESPIRATORY SENSITIZATION:
TDI: Respiratory sensitization has developed in people working with TDI. Sensitization is usually caused by a very large exposure, or by
multiple exposures. However, symptoms of sensitization have occurred in some workers exposed frequently to low levels of TDI (0.0003
to 0.03 ppm). Although varying periods of exposure (1 day to years) may elapse before sensitization occurs, it develops more often during
the first few months of exposure. Sensitized individuals react to very low levels of TDI (below 0.001 ppm) that have no effect on
unsensitized people. At first, the symptoms may appear to be a cold or mild hay fever. However, severe asthmatic symptoms can develop
and include wheezing, chest tightness, shortness of breath, difficulty breathing and/or coughing. Fever, chills, general feelings of
discomfort, headache, and fatigue can also occur. Symptoms may occur immediately upon exposure (within an hour), several hours after
exposure or both, and/or at night. Typically, the asthma improves with removal from exposure (e.g. weekends or vacations) and returns, in
some cases, in the form of an ??acute attack??, on renewed exposure. Sensitized people who continue to work with TDI may develop
symptoms sooner after each exposure. The number and severity of symptoms may increase. Death has occurred in sensitized individuals
accidentally exposed to relatively low concentrations of TDI. Animal studies indicate that respiratory sensitivity to TDI may result from
dermal as well as inhalation exposures. Following removal from exposure, some sensitized workers may continue to show a slow decline
in lung function and have persistent respiratory problems such as asthmatic symptoms, chronic bronchitis and hypersensitivity to TDI for
months or years. Others recover complete lung function within months if they have no further isocyanate exposure. TDI may also cause
hypersensitivity pneumonitis, another allergic lung disease, which is characterized by symptoms such as shortness of breath, fever,
malaise, non-productive cough, and chills. Several studies have shown that long-term exposure to TDI at levels as low as 0.002-0.003 ppm
may cause impaired lung function such as diminished respiratory capacity. Cross-sensitization between different isocyanates may occur.
People sensitized to TDI have shown sensitization to methylene bisphenyl isocyanate (MDI) and hexamethylene-1,6-diisocyanate (HDI),
where no previous exposure to MDI or HDI was known. Exposure to isocyanates is likely to cause aggravation to individuals with existing
respiratory disease, such as chronic bronchitis, and emphysema. (1)
Para toluenesulfonyl Isocyanate: May cause sensitization by inhalation. This product is a recognized allergen that can cause chronic
respiratory obstructive airway diseases. (2)
PGMEA, Toluene, MEK, Calcium Oxide: No human or animal information is available.
SKIN CONTACT:
Carbon black: Fine particles can become embedded in the skin and trapped in hair follicles causing discolouration (carbon black ??tattoos??)
and follicular blackheads. (1)
SKIN SENSITIZATION:
TDI: Repeated skin contact with TDI has caused skin sensitization in humans, although the condition is not common. Once a person is
sensitized, contact with even a small amount of TDI can cause outbreaks of dermatitis with symptoms such as redness, rash, itching and
swelling. This can spread from the hands or arms to the face and body. Some people who inhaled TDI developed extensive skin rashes that
lasted 1-1.5 weeks. There was no direct skin contact with the liquid. (1)
NERVOUS SYSTEM:
Toluene, MEK: Inhalation of solvents such as toluene and MEK may cause nervous system problems. Numerous studies of rotogravure
printers, painters and rubberized-matting workers with chronic exposure to toluene are inconclusive about chronic central nervous system
(CNS) damage. Some studies report changes such as memory loss, sleep disturbances, loss of ability to concentrate, or incoordination,
while others report no effects. Recent studies using sensitive neurobehavioral tests have shown altered scores for exposed workers but
whether or not these indicate CNS damage is not clear. (1)
PGMEA, TDI, Calcium Oxide, Carbon Black: No human or animal information is available.
TARGET ORGANS:
Toluene: In two cases of acute occupational exposure of toluene, there were no blood disorders, liver or kidney damage. Historical reports
of blood effects caused by toluene are more than likely due to benzene contamination. Liver and kidney effects, as well as heart
disturbances, have been reported in cases of solvent abuse (glue-sniffing). These extreme exposures are not relevant to occupational
situations. Reversible kidney failure has resulted from a severe occupational exposure in a paint factory. In epidemiological studies on
workers exposed long-term to levels up to 200 ppm, there was no clear evidence of kidney damage. Occupational exposure to up to
500 ppm toluene has not been associated with liver effects. There is some evidence to suggest that long-term exposure to toluene may
affect hearing. However, the limited information available does not allow a conclusion to be drawn. Although minor changes in blood
parameters have been observed, it is generally accepted that toluene does not cause significant blood disorders. (1)
PGMEA, TDI, MEK, Calcium Oxide: No human or animal information is available.
CARCINOGENICITY:
No ingredient of this product is reported to cause cancer.
PGMEA, Calcium Oxide: No human or animal information is available. The International Agency for Research on Cancer (IARC) has not
evaluated the carcinogenicity of these chemicals. The American Conference of Governmental Industrial Hygienists (ACGIH) has not listed
these chemicals. The US National Toxicology Program (NTP) has not listed these chemicals in its report on carcinogens. (1)
Toluene: There have been several human population studies which have examined the possible relationship between toluene exposure and
cancer. Cancers of most sites were not significantly associated with toluene exposure in any study. Stomach cancer mortality, lung cancer
rates and colorectal cancers were evaluated in some studies, but not others. Considering the multiple exposures in most studies and the
inconsistencies in findings, it is not possible to conclude that toluene exposure is associated with cancer in humans. The International
Agency for Research on Cancer (IARC) has concluded there is inadequate evidence for the carcinogenicity of toluene in humans.
Alsan 500 Revision date: December 13, 2007  SECTION III. POTENTIAL HEALTH EFFECTS
CARCINOGENICITY:
Toluene (continued): There is evidence suggesting a lack of carcinogenicity to o-toluene in experimental animals. The International
Agency for Research on Cancer (IARC) has concluded that this chemical is not classifiable as to its carcinogenicity to humans (Group 3).
The American Conference of Governmental Industrial Hygienists (ACGIH) has designated this chemical as not classifiable as a human
carcinogen (A4). The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens. (1)
TDI: The International Agency for Research on Cancer (IARC) has concluded that this chemical is possibly carcinogenic to humans
(Group 2B). The American Conference of Governmental Industrial Hygienists (ACGIH) has designated this chemical as not classifiable as
a human carcinogen (A4). ACGIH has published a Notice of Intended Change proposing that the carcinogenicity designation be changed
to A3 (animal carcinogen). The US National Toxicology Program (NTP) has listed this chemical as reasonably anticipated to be a human
carcinogen. (1)
MEK: A mortality study of 446 people who had worked at MEK dewaxing plants concluded that there was no evidence of a cancer hazard.
The average follow-up was 14 years. This study is limited by the small size of the cohort and the relatively short follow-up period.
Therefore, it does not necessarily prove that MEK is not a carcinogen. There is no other information available. The International Agency
for Research on Cancer (IARC) has not evaluated the carcinogenicity of this chemical. The American Conference of Governmental
Industrial Hygienists (ACGIH) has not assigned a carcinogenicity designation to this chemical. The US National Toxicology Program
(NTP) has not listed this chemical in its report on carcinogens. (1)
Carbon Black: The International Agency for Research on Cancer (IARC) has concluded that there is inadequate evidence for the
carcinogenicity of carbon black to humans and that there is sufficient evidence that carbon black is carcinogenic to experimental animals.
The International Agency for Research on Cancer (IARC) has concluded that this chemical is possibly carcinogenic to humans (Group
2B). The American Conference of Governmental Industrial Hygienists (ACGIH) has designated this chemical as not classifiable as a
human carcinogen (A4). The US National Toxicology Program (NTP) has not listed this chemical in its report on carcinogens. (1)
Benzoyl Chloride: Small human population studies have shown an increase in lung cancers in employees with combined exposure to
benzoyl chloride an alpha-chlorinated toluenes. The International Agency for Research on Cancer (IARC) has determined that there is
limited evidence for the combined exposure of alphachlorinated toluenes and benzoyl chloride to humans. There is inadequate evidence for
the carcinogenicity of benzoyl chloride to experimental animals. The International Agency for Research on Cancer (IARC) has concluded
that this chemical is probably carcinogenic to humans (Group 2A). The American Conference of Governmental Industrial Hygienists
(ACGIH) has designated this chemical as not classifiable as a human carcinogen (A4). The US National Toxicology Program (NTP) has
not listed this chemical in its report on carcinogens. (1)
TERATOGENICITY, EMBRYOTOXICITY, FETOTOXICITY:
PGMEA: Animal studies have shown that the chemically-similar PGME has no teratogenic or embryotoxic effects. Thus, none are
expected for PGMEA. (1)
Toluene: Toluene is a developmental toxicity hazard, based on information obtained from animal studies. Fetotoxicity (reduced foetal
weight), behavioural effects (effects on learning and memory) and hearing loss (in males) have been observed in the offspring of rats
exposed by inhalation to 1200 or 1800 ppm toluene. These effects were observed in the absence of maternal toxicity. A detailed review of
toluene and its potential to cause teratogenicity/embryotoxicity in occupational situations has been published. This review concludes that
although many occupational studies have evaluated general solvent exposure in general or to some solvent classes, with toluene exposure
addressed as a co-exposure or identified as a common exposure in a sub-group. Outcomes of concern included spontaneous abortion
(miscarriage) and teratogenicity (congenital malformations). Six studies examined the association of toluene exposure with spontaneous
abortions. Four of the six studies were performed on similar groups of Finnish workers, by the same group of researchers, which can
reduce overall confidence in the conclusions. Despite this and other limitations (e.g. recall bias, multiple chemical exposures), these
studies do provide evidence suggesting there may be an association between occupational toluene exposure and the occurrence of
spontaneous abortions. Nevertheless, further research is required before it will be possible to conclude that there is a causal relationship
between toluene exposure and an increased incidence of spontaneous abortions. One study has reported an increased incidence of
malformations (renal-urinary and gastrointestinal) in children born to women with a history of exposure to aromatic solvents, particularly
toluene. However, it is not possible to draw specific conclusions regarding toluene from this study, because the toluene-specific results
were based on a very small number of workers who were exposed to multiple chemicals. Concerns about the potential teratogenicity of
toluene in humans have also arisen due to effects (usually renal/urinary) seen in solvent abuse cases (glue-sniffing). These extreme
exposures to toluene, as well as other confounding factors such as tobacco and alcohol abuse, are not relevant to occupational situations.
(1)
MEK: Some researchers have pointed to a concern that solvent exposure may have led to congenital defects in children born to female
workers. One of the solvents mentioned is MEK, but it is not possible to implicate any particular solvent due to the extent of combined
exposure. Three animal studies have shown fetotoxicity (skeletal anomalies) at doses which did not produce any or only very slight
maternal toxicity. (1)
TDI, Calcium Oxide, Carbon Black: No human or animal information is available. (1)




Alsan 500 Revision date: December 13, 2007  SECTION III. POTENTIAL HEALTH EFFECTS
REPRODUCTIVE TOXICITY:
Toluene: No conclusions can be drawn based on the available human information. Reproductive effects have not been observed in animal
studies. A review of toluene and its potential to cause reproductive toxicity in workers has been published. Three cross-sectional studies
evaluated fertility in women exposed to toluene or in the wives of exposed men. No conclusions can be drawn based on these studies, due
to limitations such as selection bias, recall bias, and the fact that the workers were exposed to other potentially harmful chemicals. Another
study suggests that menstrual function is not affected by exposure to toluene. Another report describes testicular atrophy and reduced
spermatogenesis in one man who abused toluene for 10 years. This extreme exposure situation is not relevant to occupational
exposures. (1)
PGMEA, TDI, MEK, Calcium Oxide, Carbon Black: No human or animal information is available.
MUTAGENICITY:
Toluene: Results from the available human studies are inconclusive. Both positive and negative results have been obtained in human
studies, but no studies were carried out with toluene exposure only, or with adequate control of other factors. Positive results have been
obtained in some studies using live animals, but the studies either used an irrelevant route of exposure (intraperitoneal) or there are
insufficient details available for evaluation. (1)
MEK: There is no human information available. In vivo animal studies, mammalian in vitro studies and virtually all short-term
mutagenicity studies on test cell systems have been negative. (1)
TDI: It is not possible to conclude that TDI is mutagenic. There is no human information available. (1)
PGMEA, Calcium Oxide, Carbon Black: No human or animal information is available.
TOXICOLOGICALLY SYNERGISTIC MATERIALS:
Toluene: Exposure to other solvents such as benzene, xylene and ethanol (alcohol) slows the rate of clearance of toluene from the body,
thereby enhancing the toxicity of toluene. (1)
MEK: There are several human case reports of neurological effects resulting from high exposure to MEK in combination with other
solvents. Animal studies have confirmed synergism between MEK and ethyl n-butyl ketone, methyl n-butyl ketone, n-hexane, carbon
tetrachloride, 2,5-hexanedione and chloroform. Principal target organs involved in toxicological interactions are the nervous system and
liver, although the lung has also been implicated. (1)
PGMEA, TDI, Calcium Oxide: No human or animal information is available.
POTENTIAL FOR ACCUMULATION:
PGMEA: Does not accumulate. PGMEA is rapidly metabolized to PGME and acetic acid. Animal studies indicate that PGME is rapidly
metabolized and eliminated from the body. PGMEA was rapidly and extensively metabolized to propylene glycol monomethyl ether and
acetic acid (which is a normal body substance), and eliminated in the same manner as propylene glycol monomethyl ether (in the expired
air as carbon dioxide, in the urine and very small amounts in the feces). At very high doses of PGMEA, the acetic acid formed in the
hydrolysis, may have adverse effects. (1)
Toluene: Toluene is readily absorbed by inhalation or ingestion and tends to be deposited more in tissues that are fatty or have a rich blood
supply (e.g. brain, liver, kidney, fat). There was no evidence of accumulation in rats with repeated inhalation exposure to 300 ppm.
Toluene is metabolized in the liver and excreted by the kidneys in the urine. It can also be exhaled unchanged. (1)
TDI: TDI probably does not accumulate in the body. It can enter the body by inhalation or by ingestion. It is probably metabolized to
toluenediamine, which is metabolized further and excreted. (1)
Calcium Oxide: Does not accumulate in the body. Calcium ions are normally found in the body. About one third of ingested calcium ion is
absorbed. Calcium ion is excreted mainly in the feces and the urine. (1)
MEK: No human or animal information is available.

SECTION IV. FIRST AID MEASURES
SKIN CONTACT:
Remove contaminated clothing. Wash thoroughly with soap and water. If irritation persists, get medical attention.
EYE CONTACT:
Flush thoroughly with water for at least 15 minutes. If irritation persists, get immediate medical attention.
INHALATION:
In case of gas or vapour inhalation, move victim to fresh air. If breathing is difficult, give oxygen. If breathing stops, give respiratory
assistance. Obtain medical assistance.
TDI: Symptoms of pulmonary oedema can be delayed up to 48 hours after exposure. (1)
INGESTION:
Do not induce vomiting. Immediately contact local poison control centre. Should vomiting occur, be sure to keep the victim??s head below
hips to avoid aspiration of vomit into the lungs. Maintain the victim at rest and obtain immediate medical attention.




Alsan 500 Revision date: December 13, 2007  SECTION V. FIRE-FIGHTING MEASURES
FLAMMABILITY: Flammable liquid, Class IB (NFPA 30)
EXPLOSION DATA: Sensitivity to mechanical impact: No
Sensitivity to static charge: Can accumulate static charge by flow
FLASH POINT: 12??C
AUTO-IGNITION TEMPERATURE : Not available
FLAMMABILITY LIMITS IN AIR: (% in volume) Not available
FIRE AND EXPLOSION HAZARDS:
This product and its vapours are easily ignited by heat, sparks or flames. Vapours may form explosive mixtures with air. Vapours are
heavier than air and may travel a considerable distance to a source of ignition and flash back to a leak or open container. The product may
ignite on contact with strong oxidizing agents. Do not cut, puncture or weld empty containers.
COMBUSTION PRODUCTS:
Irritating and/or toxic gases or fumes may be generated by thermal decomposition or combustion (1-methoxy-2-methylene (vinyl ether),
acetic acid, carbon oxide, nitrogen oxide, trace of hydrocyanic acid, trace of hydrochloric acid, formaldehyde, acetaldehyde,
methylglyoxal, hydrogen cyanide, phosphorous oxides). Toxic and/or irritating gases or fumes can emanate from empty containers when
submitted to high temperatures.
FIRE FIGHTING INSTRUCTIONS:
Irritating and/or toxic gases or fumes may be generated by thermal decomposition or combustion. Approach fire from upwind. Evacuate
area and fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Always stay away from containers because
of the high risk of explosion. Wear self-contained breathing apparatus and appropriate protective clothing in accordance with standards.
Stop leak before attempting to put out the fire. Move containers from fire area if this can be done without risk. If leak cannot be stopped,
and if there is no risk to the surrounding area, let the fire burn itself out. Cool containers with flooding quantities of water until well after
fire is out.
TDI: Water or water-based foam, if used in very large quantities, may be effective for fighting fires involving toluene diisocyanate (TDI).
However, care must be taken since the reaction between water or water-based foam and not TDI can be vigorous. TDI and its
decomposition products, such as hydrogen cyanide and nitrogen oxides, are extremely hazardous to health. (1)
MEANS OF EXTINCTION:
Dry chemical powder, CO2, foam. Use of water spray when fighting fire may be inefficient because of the low flash point of the product.

SECTION VI. ACCIDENTAL RELEASE MEASURES
RELEASE OR SPILL:
Ventilate area. Wear appropriate protective equipment during cleanup. Eliminate all sources of ignition. Shut off source of leak if you can
do it without risk. Contain the spill. Absorb with absorbents or cover with dry earth, sand or other non-combustible material and transfer to
containers. Sweep or shovel into containers with lids, use clean non-sparking tools to collect absorbed material. Cover and remove to
appropriate well-ventilated area until disposal. Wash spill area with soap and water. Prevent entry into waterways, sewers, and basements.
Dispose of this product according to environmental regulations.

SECTION VII. HANDLING AND STORAGE
HANDLING:
This product is flammable and toxic. Avoid contact with eyes, skin and clothing. Do not ingest. Avoid breathing vapour or dust. Wash
thoroughly after handling. Before handling, it is very important that ventilation controls are operating and protective equipment
requirements are being followed. People working with this product should be properly trained regarding its hazards and its safe use.
Eliminate all ignition sources (e.g. sparks, open flames, hot surfaces). Keep away from heat. Tightly reseal all partially used containers. Do
not cut, puncture or weld empty containers.
STORAGE:
Store up side down in a cool well-ventilated area out of direct sunlight and away from moisture, heat and ignition sources. Keep storage
areas clear of combustible materials. No smoking near storage area. Store away from incompatible materials. Store the product according
to occupational health and safety regulations and fire and building codes. Storage area should be clearly identified, clear of obstruction and
accessible only to trained and authorized personnel. Inspect periodically for damage or leaks. Have appropriate fire extinguishers and spill
clean-up equipment near storage area. Inspect all containers to make sure they are properly labelled.

SECTION VIII. EXPOSURE CONTROLS / PERSONAL PROTECTION
HANDS: Wear gloves made from butyl rubber or Teflon.
RESPIRATORY: If the exposure limit is exceeded, if use is performed in a poorly ventilated confined area, use an
approved respirator in accordance with standards.
EYES: Wear chemical safety goggles in accordance with standards.
OTHERS: Eye bath and safety shower.
CONTROL OF VAPOURS: Local exhaust is needed to control vapour and dust level to below recommended limits.




Alsan 500 Revision date: December 13, 2007  SECTION IX. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: Liquid
ODOUR AND APPEARANCE: Grey or brown viscous liquid with solvent odour
ODOUR THRESHOLD: Not available
VAPOUR DENSITY (air = 1): Heavier than air
EVAPORATION RATE (ether = 1): Not available
BOILING POINT (760 mm Hg): Not available
FREEZING POINT: Not available
>1
SPECIFIC GRAVITY (H2O = 1):
SOLUBILITY IN WATER (20??C): Insoluble
VOLATILE ORGANIC COMPOUND (V.O.C.) CONTENT: 290 g/L
VISCOSITY: Not available

SECTION X. STABILITY AND REACTIVITY
STABILITY:
This material is stable at handling and storage conditions recommended under the section VII.
CONDITIONS OF REACTIVITY:
Avoid excessive heat. Exposed to high temperatures, this product can emit dangerous decomposition products such as fumes, carbon
oxide, nitrogen oxide, hydrocyanic acid, amines and alcohols.
INCOMPATIBILITY:
Keep away from oxidizing agent and from highly acid or basic materials to avoid exothermic reactions.
- STRONG OXIDIZING AGENTS - Reacts violently with fire or explosion risk.
- WATER ?? Reacts non-violently at room temperature with release of heat to form carbon dioxide and inert material made up of polyureas
which could rupture closed containers. Toluenediamine is formed as an intermediate product in the reaction. Above 50??C, the reaction
becomes progressively more vigorous.
- AMINES, ALCOHOLS, ACIDS, OR BASES ?? May react violently with generation of heat. METAL COMPOUNDS (e.g.
organometallic catalysts, such as organotin compounds) ?? May polymerize with the generation of heat and pressure.
- ALKALINE METALS ?? The reaction is exothermal and flammable compounds can emanate.
- HALOGENS ?? The reaction is exothermal and flammable compounds can emanate.
- AMIDES, PHENOLS, MERCAPTANS, URETHANES, UREAS AND SURFACE ACTIVE AGENTS (surfactants, e.g. non-ionic
detergents) ?? May react vigorously or violently with the generation of heat. (1)
HAZARDOUS DECOMPOSITION PRODUCTS:
This product slowly reacts with water and may cause an emanation of carbonic gas which would lead to pressure increasing in closed
containers. Peroxides can also form and generate the same situation. TDI will produce toluenediamine in reaction with water.
HAZARDOUS POLYMERISATION:
TDI can be subjected to an uncontrolled exothermal polymerisation by contact with water at high temperatures.
STABILITY AND REACTIVITY COMMENTS:
Isocyanates are very reactive compounds and are highly reactive toward a large number of compounds with active hydrogens, particularly
at high temperatures and in the presence of catalysts. (1)

SECTION XI. TOXICOLOGICAL INFORMATION
TOXICOLOGICAL DATA:
Toluene: (1) LC50 (inhalation, rat): 7 350 ppm (4-hour exposure)
LD50 (oral, rat): 2 600-7 500 mg/kg
LD50 (dermal, rabbit): 12 225 mg/kg
TDI: (1) LC50 (rat): 14 ppm (4-hour exposure) (composition unspecified)
LD50 (oral, rat): > 4,000 mg/kg (80% 2,4-TDI: 20% 2,6-TDI)
LD50 (dermal, rabbit): 10,000 mg/kg (composition unspecified)
MEK: (1) LC50 (inhalation, rat): 11,700 ppm (4-hour exposure)
LD50 (oral, rat): 2,740 mg/kg cited as 3.4 ml/kg
LD50 (dermal, rabbit): > 5,000 mg/kg
Tris(nonylphenyl)phosphite: (2) LD50 (inhalation, rat): > 2000 mg/kg
Carbon Black: (1) LC50 (inhalation, rat): 6 750 mg/kg (4-hour exposure)
LD50 (oral, rat): Not available
LD50 (dermal, rabbit): Not available
N-(trichloromethylthio)phthalimide: (1) LC50 (inhalation: rat): 1.89 mg/l (4-hour exposure)
LD50 (oral, rat): > 9 000 mg/kg
LD50 (dermal): > 2 000 mg/kg


Alsan 500 Revision date: December 13, 2007  SECTION XI. TOXICOLOGICAL INFORMATION
TOXICOLOGICAL DATA: (continued)
Benzoyl Chloride: (1) LC50 (inhalation, rat): 230 ppm (4-hour exposure); cited as 1.87 mg/L (2-hour exposure)
LD50 (oral, rat): 1900 mg/kg
LD50 (dermal, rabbit): 790 mg/kg
PGMEA, Carbamic acid, 1,6-hexanediylbis-, bis [2-[2-(1-methylethyl)-3-oxazolidinyl]ethyl] ester, Calcium Oxide, Para toluenesulfonyl
Isocyanate: No information available.
EYE IRRITATION:
TDI: Application of 80% toluene-2,4-diisocyanate (2,4-TDI):20% 2,6-TDI (possibly undiluted) caused moderate pain, redness, swelling
and discharge in rabbits. Washed eyes healed completely in 14 days. Corneal injury and redness were seen in the unwashed eyes at 21
days. (1)
Benzoyl Chloride: Benzoyl chloride is corrosive. Application of 0.1 ml of benzoyl chloride was corrosive in rabbits. No scoring
information was provided. (1)
SKIN IRRITATION:
TDI: Application of 0.5 ml in a covered test for 4 hours caused corrosion in 6/6 rabbits tested. Prolonged contact with the skin can cause
redness, swelling, blistering and burns. (1)
Benzoyl Chloride: Prolonged exposure (24-hour) to benzoyl chloride caused corrosion. Application of 0.5 ml benzoyl chloride, under a
cover for 24 hours, was corrosive to the ears of rabbits. No scoring information was provided. (1)
Effects of Short-Term (Acute) Exposure
INHALATION:
Toluene: The major effect of toluene is on the central nervous system (CNS). Studies with rats have shown that a concentration up to
approximately 1000 ppm causes excitation and increased activity. At approximately 2000 ppm, there is CNS depression with drowsiness,
incoordination and unconsciousness. Death at higher concentrations is from respiratory failure. Animal studies have indicated that toluene
is not directly toxic to the cardiovascular system. Recovery is rapid following cessation of exposure. Studies indicate no permanent
damage to body systems. Studies in rats have shown hearing loss at high frequencies following toluene exposure both by inhalation
(concentration threshold between 700 and 1000 ppm) and orally (620 mg/kg/day for 4 weeks). This effect has also been observed in a
mouse strain that had a genetic predisposition to hearing loss. (1)
MEK: Very high concentrations have produced irritation of the nose and eyes, followed by a central nervous system depression with
incoordination, unconsciousness, gasping respiration and death. Guinea pigs were exposed to 3,300 to 100,000 ppm for 13.5 hours. No
abnormal signs were observed during or following exposure to 3300 ppm for 810 minutes. Exposure to 10,000 ppm produced irritation (2-
4 minutes), lacrimation (40 minutes), incoordination (90 minutes) and unconsciousness (240-280 minutes). Gasping respiration was
produced during 20 and 180-minute exposures to 33,000 and 100,000 ppm. Death resulted from 45 and 200-minute exposures to 33,000
and 100,000 ppm. Slight congestion of the brain and marked congestion and emphysema of the lungs, liver and kidneys were observed in
animals that died during exposure. Animals that survived subsequently recovered. The concentration which reduced the respiratory rate of
mice by 50% (RD50) was 10,745 ppm (which was very high compared to other irritants tested). This indicates that MEK is a sensory
irritant (causes burning and painful irritation of the nose and eyes) at very high concentrations. (1)
TDI: Inhalation of sublethal concentrations by mice, rats, rabbits and Guinea pigs caused severe respiratory effects such as bronchitis,
bronchopneumonia, emphysema, and bleeding of the lungs. TDI is a sensory irritant. Sensory irritants inhibit respiration. (1)
Carbon Black: Some effects on the lower lung (alveolar thickening and atelectasis) were observed in rats following continuous inhalation
of 4 mg/m3 channel black for 16 days. Conflicting or insignificant results were obtained in 3 other studies. (1)
PGMEA, Calcium Oxide: No information available.
INGESTION:
TDI: TDI has been reported to have gastrointestinal and liver effects when administered orally to animals. (1)
PGMEA, MEK: No information available.
EYE IRRITATION:
PGMEA (rabbit): Somewhat painful and irritating to the eyes. (1)
Toluene: Toluene is a mild eye irritant. In an OECD-compliant test, application of 0.1 ml undiluted toluene produced no to mild irritation
in rabbits. Application of 0.1 ml of undiluted toluene in another OECD-compliant test protocol produced slight irritation in rabbits.
Application of 0.005 ml of an excess of a 40% solution of toluene caused severe eye injury in rabbits. These results are not consistent with
the reports that used undiluted toluene in OECD-compliant tests. The results of this study are therefore questionable. (1)
MEK: Application of 0.005 ml of undiluted methyl ethyl ketone (MEK) to rabbit eyes produced severe irritation. Application of pure,
30%, 10% and 1% solutions of MEK in a standard Draize test using rabbits resulted in moderate/severe irritation for pure MEK and mild
irritation for all other concentrations. In an interlaboratory comparison study, where eye irritation was evaluated in rabbits using a standard
Draize test, 71% of the laboratories rated MEK as an eye irritant (degree not specified). The corneas of Guinea pigs exposed to 100,000
ppm vapour for 30 minutes or more became opaque. In some cases, this effect persisted for the 8-day observation period. (1)
Tris(nonylphenyl)phosphite: Not irritating for eyes of rabbits. (2)
Carbon Black: Suspensions of carbon and graphite produced no signs of inflammation even when injected into the eyes of rabbits. (1)
N-(trichloromethylthio)phthalimide: Severely irritating to rabbit eye. (2)
Alsan 500 Revision date: December 13, 2007  SECTION XI. TOXICOLOGICAL INFORMATION
SKIN IRRITATION:
PGMEA (rabbit): Repeated applications were not very irritating to rabbit and did not cause absorption of significant amounts, even when
applied repeatedly for a 2-week period. (1)
Toluene: Toluene is a moderate skin irritant. In an OECD-compliant test, administration of 0,5 ml of undiluted toluene to intact skin,
under a semi-occlusive cover, for 4 hours produced moderate irritation in rabbits. Another OECD-compliant test, showed slight irritation
in rabbits following the application of 0,5 ml of undiluted toluene for 4 hours. There is insufficient information provided to properly
evaluate these test results. Other test protocols have shown moderate irritation in intact and abraded skin, with prolonged exposure (23
hours), and in a study that does not strictly meet OECD guidelines. Application of 0.5 of undiluted toluene for 4 hours, to intact and
abraded skin, produced moderate irritation in rabbits. Application of 0.5 ml of undiluted toluene for 23 hours, to intact and abraded skin,
produced moderate irritation in rabbits. Application of 0.01 ml of undiluted toluene produced moderate irritation in rabbits. (1)
MEK: Application of 0.01 ml of undiluted MEK to the clipped rabbit skin for 24 hours (uncovered) resulted in mild irritation. Application
of full strength MEK to intact or abraded rabbit skin for 24 hours under occlusion was moderately irritating. In an interlaboratory
comparison study, where skin irritation was evaluated in rabbits by covered application of 0.5 ml to shaved skin for 24 hours, over 70% of
the laboratories rated MEK as a mild skin irritant. MEK did not produce sensitization in the mouse ear thickness test. (1)
Tris(nonylphenyl)phosphite: Skin irritant for rabbit. (2)
N-(trichloromethylthio)phthalimide: Mildly irritating to rabbit skin. (2)
Para toluenesulfonyl Isocyanate: Isocyanates are known to cause skin sensitization in humans. (2)
SENSITIZATION:
Tris(nonylphenyl)phosphite: Sensitizing for Guinea pig. (2)
N-(trichloromethylthio)phthalimide: Sensitizer (Guinea pig). (2)
Effects of Long-Term (Chronic) Exposure
INHALATION:
PGMEA (rat, mice): Repeated exposures at 300 and 1000 ppm for two weeks (6 hours/day, 5 days first week, 4 days second week)
produced no adverse effects. There were minor changes found at very high exposures (3000 ppm) ?? slight increase in liver weight for
females, slight effect on kidney function and slight to moderate injury to the lining of the nose. The latter effect was more severe with
mice. It was suggested that this effect was related to acetic acid resulting from hydrolysis of PGMA in the nose. There were no effects on
thymus and spleen weights, on bone marrow or blood. (1)
Toluene: Daily inhalation by rats of toluene concentrations below 400 ppm for up to 24 months resulted in no significant toxicity.
Evidence for chronic CNS neurotoxicity is inconclusive. Numerous studies on rats and mice have shown reduced performance on some
neurobehavioral tests but not others, both during and after toluene inhalation exposures (usually at greater than 500 ppm). Where tests
were repeated after an exposure-free period, most results were the same as controls. The significance of minor changes in brain cells or in
behavioural tests is not known. (1)
TDI: Rats, Guinea pigs and rabbits exposed to 0.1 ppm, 6 hours/day, 5 days/week for up to 58 exposures or 6 hours/day for 38 consecutive
days, developed lung inflammation. Lung damage generally increased in severity for several days after exposure ended. (1)
MEK: Exposure to 5000 ppm for 13 weeks produced an exposure-related effect on body and liver weights in male and female rats, as well
as a depression in brain weight in females. Guinea pigs and rats were exposed to 235 ppm for 12 weeks (5 days/week, 7 hours/day). There
were no deaths nor signs of intoxication for rats. There were deaths in both control and experimental Guinea pigs (2 in each group).
Extensive neurological studies with high exposures have shown no effects. In one study, rats were initially exposed to 10 000 ppm which
was reduced to 6000 ppm due to severe irritation of the upper respiratory tract. Temporary signs of muscle incoordination and gait
disturbances were observed throughout the exposure. Exposures continued for only 7 of the planned 15 weeks since animals died of
bronchopneumonia with no neurological symptoms. In the other study, rats were exposed to 1125 ppm continuously for up to 55 days with
no neurotoxicity. (1)
Carbon Black: Many inhalation exposure studies have been conducted in experimental animals. In general, these studies show that
excessive accumulation of carbon black in the lungs can result in significant inflammatory responses (chronic bronchitis, alveolitis and
alveolar proteinosis). In 2 studies, slight to moderate lung scarring (fibrosis) was observed in rats following exposure to 11.6 mg/m3 and a
marked fibrotic response was observed in rats following exposure to high concentrations (approximately 52.8 mg/m3). Only mild fibrotic
effects were observed at airborne concentrations of approximately 7.1 mg/m3. Other studies have not shown fibrotic effects. IARC has
suggested that the inflammatory response to an excessive lung burden of carbon black may subsequently result in fibrotic changes. Some
research has been conducted using the intratracheal route of administration. This research has not been evaluated here because of its
questionable relevancy to occupational exposures. (1)
Para toluenesulfonyl Isocyanate: This product may cause chronic respiratory and obstructive airway diseases. Allergic reactions may
develop after inhalation of low concentrations, also several hours after exposure. (2)
RESPIRATORY SENSITIZATION:
TDI: Concentration dependent respiratory sensitization has been produced in Guinea pigs. Threshold levels of 0.25 to 0.36 ppm TDI (80%
2,4-TDI:20% 2,6-TDI) have been observed. (1)
Para toluenesulfonyl Isocyanate: Isocyanates are known to cause respiratory sensitization in humans. (2)

Alsan 500 Revision date: December 13, 2007  SECTION XI. TOXICOLOGICAL INFORMATION
INGESTION:
PGMEA (rat): A single dose of 3 ml/kg produced no deaths; 10 ml/kg caused death in 3 of 5 animals tested. (1)
Toluene: No significant toxicity was seen after oral administration of up to 590 mg/kg to female rats for up to six months. (1)
MEK: Exposure of mice in LD50 studies has resulted in incoordination, unconsciousness, respiratory depression and death. MEK is easily
aspirated into the lungs. When aspiration of MEK was induced in 6 rats, there was a high mortality with rapid onset. (1)
TDI: No information available.
SKIN SENSITIZATION:
TDI: Skin and respiratory sensitization were produced in animals by direct application of 2,4-TDI to the skin. No dermal or respiratory
sensitization was detected in animals exposed to 0.02 ppm for 15 weeks. (1)
Para toluenesulfonyl isocyanate: This product may cause skin disorders and allergies. (2)
MEK, PGMEA: No information available.
CARCINOGENICITY:
Toluene: The International Agency for Research on Cancer (IARC) has concluded there is inadequate evidence for the carcinogeneicity of
toluene in experimental animals. Toluene was not carcinogenic in mice and rats exposed by inhalation to up to 1200 ppm for 24 months.(1)
TDI: The International Agency for Research on Cancer (IARC) has determined there is sufficient evident for the carcinogenicity of
toluene diisocyanate to experimental animals. (1)
Carbon Black: The International Agency for Research on Cancer (IARC) has determined that there is sufficient evidence that carbon
black is carcinogenic to experimental animals. An increased incidence of lung tumours has been observed in 3 studies using female rats,
but not in male rats or in mice. No increase in skin tumours was observed following skin application of either oil suspension or water
suspensions containing 10% or 20% carbon black (various types). When benzene extracts of carbon black were used, however, increases in
skin tumours were observed. (1)
N-(trichloromethylthio)phthalimide: A two-year feeding study of Folpan indicated duodenal tumours in mice after repeated
administration of high dose levels. The NOAEL (No Observed Adverse Effect Level) was 450 ppm. No evidence of carcinogenicity was
observed in long-term studies with rats. Information on the mechanism of tumour formation establishes a threshold for the duodenal
tumours, and indicates that this tumour type is not relevant for human risk assessment at likely exposure levels. (2)
Benzoyl Chloride: Small numbers of skin tumours have been observed following the skin application of benzoyl chloride to mice.
Inhalation exposure has produced no significant increase in tumour incidence in mice. The International Agency for Research on Cancer
(IARC) has concluded that there is inadequate evidence for the carcinogenicity of benzoyl chloride to experimental animals. (1)
PGMEA, MEK, Calcium Oxide: No information available.
TERATOGENICITY, EMBRYOTOXICITY, FETOTOXICITY:
Toluene: Toluene does cause developmental effects in animals, based on fetotoxicity (reduced foetal weight), behavioural effects (effects
on learning and memory) and hearing loss (in males) were observed in the offspring of rats exposed by inhalation to 1200 or 1800 ppm
toluene. These effects were observed in the absence of maternal toxicity. Rats (16/group) were exposed to 1800 ppm toluene or clean air
on days 7-20 of pregnancy. The dose was targeted so as not to induce marked toxicity in the mothers and no toxicity was seen.
Fetotoxicity, as evidenced by reduced birth weight, was observed in the offspring. (1)
MEK: One rat study indicated that fetotoxicity (skeletal anomalies) occurred at 1000 ppm. This study also points to teratogenicity at a
higher dose (3000 ppm). Maternal toxicity was not produced at either dose. Two follow-up studies by the same researchers also showed
fetotoxicity in rats and mice in the presence of very slight maternal toxicity. Rats were exposed by inhalation to 0, 1000 and 3000 ppm on
days 6 to 15 of gestation. At 3000 ppm, in 4/21 litters (1 foetus/litter), there was a low but statistically significant increase in
malformations. Sternebral and soft tissue anomalies were also increased. There was also a statistically significant increase in total skeletal
anomalies at 1000 ppm. Maternal toxicity was not observed. In subsequent studies, rats and mice were exposed to 0, 400, 1000 or 3000
ppm by inhalation during days 6 to 15 of gestation. There were no embryotoxic or teratogenic effects at any exposure level. At 3000 ppm,
there were fetotoxic effects (increased incidence of minor skeletal variations; delayed bone formation; reduced foetal weight) with very
slight maternal toxicity (decreased weight gain in rats; increased liver weights in mice). (1)
N-(trichloromethylthio)phthalimide: Non-teratogenic in animal studies. (2)
PGMEA, TDI, Calcium Oxide, Carbon Black: No information available.
REPRODUCTIVE TOXICITY:
Toluene: No adverse effects on reproduction were observed in several studies on both rats and mice, even at maternally toxic exposures.
Two generations of mice exposed intermittently by inhalation to 2000 ppm (6 hours/day, 7 days/week) had no reproductive effects. (1)
PGMEA, TDI, MEK, Calcium Oxide: No information available.




Alsan 500 Revision date: December 13, 2007  SECTION XI. TOXICOLOGICAL INFORMATION
MUTAGENICITY:
Toluene: There is insufficient information available to conclude that toluene is mutagenic. There is some evidence that toluene can cause
chromosome damage in vivo when administered to mice by injection, although conflicting results have been obtained and this route of
exposure is not considered relevant to occupational situations. Negative results were obtained following oral administration. There is one
report of positive results (chromosomal aberrations) in the bone marrow cells of rats exposed by inhalation. Insufficient details are
available in English to evaluate this report. Positive and negative results have been obtained in tests using cultured mammalian cells.
Negative results have been obtained in tests using bacteria. Positive and negative results have been obtained in fruit flies. (1)
TDI: Production-grade TDI (80:20 mixture) gave negative results in the in vivo mouse and rat white blood cell micronucleus test
(exposure to 0.05 or 0.15 ppm TDI for 4 weeks. Negative results were obtained for the 80:20 mixture in cultured mammalian cells. There
are conflicting reports in bacterial tests. (1)
MEK: MEK was not mutagenic in in vivo micronucleus cytogenetic assays with mice injected with 1.96 ml/kg or hamsters injected with
411 mg/kg. It also did not produce chromosomal aberrations or sister chromatid exchanges in Chinese hamster ovary cells. MEK was not
mutagenic in several cultured mammalian test systems in vitro, including human lymphocytes, both with and without metabolic activation.
MEK was not mutagenic in Salmonella typhimurium, Escherichia coli and Saccharomyces cerevisiae, both with and without metabolic
activation. In two other studies with saccharomyces cerevisiae yeast, MEK gave positive results. (1)
Tris(nonylphenyl)phosphite: This material was not mutagenic in an Ames bacterial assay. (2)
Carbon Black: Both positive and negative results have been obtained in rats in vivo studies. Positive results have been obtained in somatic
cells following inhalation exposure of rats. Generally, negative results have been obtained in short-term assays using bacteria and cultured
mammalian cells and in insects. (1)
N-(trichloromethylthio)phthalimide: Non-mutagenic (in vivo tests). (2)
PGMEA, Calcium Oxide: No information available.
SECTION XII. ECOLOGICAL INFORMATION
ENVIRONMENTAL EFFECTS:
Do not allow product or runoff from fire control to enter storm or sanitary sewers, lakes, rivers, streams, or public waterways. Block off
drains and ditches. Provincial regulations and federal regulations may require that environmental and / or other agencies be notified of a
spill incident. Spill area must be cleaned and restored to original condition or to the satisfaction of authorities. May be harmful to aquatic
life.
SECTION XIII. DISPOSAL CONSIDERATIONS
WASTE DISPOSAL:
This product is listed as hazardous waste. Consult local, state, provincial or territory authorities to know disposal methods. Also listed as
hazardous waste by the RCRA (USA); waste disposal as to follow EPA regulations. Do not dispose of waste with normal garbage or
sewers systems.
SECTION XIV. TRANSPORT INFORMATION
NAME OF PRODUCT: Alsan 500 IDENTIFICATION NUMBER: UN 1263
CLASSIFICATION (TDG - DOT): Class 3 SHIPPING NAME: Paint
CONTAINERS FOLLOW THE STANDARDS OF:
Canada: CAN / CGSB-43.150-97 PACKING GROUP: II
USA: CFR 49 parts 100 to 199
SECTION XV. REGULATORY INFORMATION
Canada - WHMIS: Class B2: Flammable liquid (flash point lower than 37.8??C).
Class D1A: Very toxic material causing severe and immediate effects.
Class D2A: Very toxic material causing other effects.
Class D2B: Toxic material causing other effects.
Canada - DSL: All constituents of this product are included on the Domestic Substances List (DSL ?? Canada)
USA - TSCA: All constituents of this product are included on the Toxic Substances Control Act Inventory (TSCA ?? United States).
HMIS (USA): NFPA (USA):
HEALTH Flammability
2
3
Health
FLAMMABILITY
3
3 2 Reactivity
(with water) REACTIVITY
1 (with water)
1
PROTECTIVE Specific hazard
2 EQUIPMENT


Alsan 500 Revision date: December 13, 2007  SECTION XVI. OTHER INFORMATION
Glossary:
ACGIH: American Conference of Governmental Industrial Hygienists
ANSI: American National Standards Institute
ASTM: American Society for Testing and Materials
CAS: Chemical Abstract Services
CFR: Code of Federal Regulations (United States)
CSA: Canadian Standardisation Association
DOT: Department of Transportation (United States)
DSL: Domestic Substances List (Canada)
EPA: Environmental Protection Agency (United States)
HMIS: Hazardous Material Information System
IARC: International Agency for Research on Cancer
LC50: (Lethal concentration50) Concentration of a substance in air that causes dead of 50% mortality of a defined animal population
LD50: (Lethal dose50) Single dose of a substance that, when administrated by a define route in an animal assay, is expected to cause the
death of 50% of a defined animal population.
NFPA: National Fire Protection Association (United States)
NIOSH: National Institute for Occupational Safety and Health
NTP: National Toxicology Program
OSHA: Occupational Safety & Health Administration (United States)
PEL: Permissible Exposure Limit
RCRA: Resource Conservation and Recovery Act (United States)
RTECS: Registry of Toxic Effects of Chemical Substances
TDG: Transportation of Dangerous Goods
TLV: Threshold Limit Value
TWA: Time-weighted average
TSCA: Toxic Substances Control Act (United States)
WHMIS: Workplace Hazardous Materials Information System (Canada)
References:
(1) CHEMINFO (2007) Canadian Centre of Organisational Health and Safety, Hamilton (Ontario) Canada
(2) Material Safety Data Sheet of the supplier.
This MSDS has been prepared by: Michel Galtier
For more information: SOPREMA Canada 1-800-567-1492
The Material Safety Data Sheets of SOPREMA Canada are available on Internet at the following site: http://www.soprema.ca
Justification of the update:
Addition of Class D1A. (Section XV)
This MSDS contains all the information required by ANSI Z-400.1-1998 standard (United States), by regulation 29 CFR Part 1910.1200 of the Hazard
Communication Standard of OSHA, and is in accordance with standard DORS/88-66 OF WHMIS Canada.
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier or any of its subsidiaries
assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any
material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain
hazards are described herein, we cannot guarantee that these are the only hazards that exist.




Alsan 500 Revision date: December 13, 2007 

BIS[2-[2-(1-METHYLETHYL)-3-OXAZOLIDINYL]ETHYL] 1,6-HEXANEDIYLBISCARBAMATE