MATERIAL SAFETY DATA SHEET

SECTION 1 - IDENTIFICATION OF PRODUCT AND COMPANY

1-866-531-8896
Pfizer Inc Emergency telephone
24 Hours
Pfizer Animal Health Hours of operation
1-800-366-5288
235 East 42nd Street Telephone
New York, NY 10017
Product name Equell?
Avermectin macrocyclic lactone
Chemical family
Anthelmintic
Therapeutic use
Odorless, white, thick, smooth paste
Description


SECTION 2 - COMPOSITION

Ingredient CAS Number Amount
Ivermectin* 70288-86-7 1.87% **
Proprietary Ingredients Not assigned 98.13%
*Hazardous
Note: Ingredient(s) indicated as hazardous have been assessed under standards
for workplace safety. The ingredients in this formulation are being held as
trade secret. In the event of a medical emergency or for use of this MSDS
outside the United States, contact the emergency telephone number listed
in Section 1 for ingredient information.

** Ivermectin is a mixture of Ivermectin component B1?? (70161-11-4) and
Ivermectin component B1?? (70209-81-3)


SECTION 3 - HAZARDS IDENTIFICATION

Signal word WARNING!
Statements of hazard TOXIC IF SWALLOWE
POSSIBLE RISK OF HARM TO THE UNBORN CHIL May cause irritation based on components.
Eye effects
May cause irritation based on components.
Skin effects
Not expected due to physical form.
Inhalation effects
Ingestion effects May be harmful if swallowed. See 'Statements of hazard', 'Known clinical
effects', and/or 'Other potential health effects' in this section.

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Adverse effects associated with the clinical use of invermectin may
Known clinical effects
include joint or muscle pain, dizziness, fever, headache, skin rash, itching,
fast heartbeat, and swelling of face or extremities.
Animal studies with ivermectin have shown a potential to cause adverse
Other potential health
effects on the fetus.
effects
This document has been prepared in accordance with standards for
NOTE:
workplace safety, which require the inclusion of all known hazards of the
product or its ingredients regardless of the potential risk. The
precautionary statements and warnings included may not apply in all
cases. Your needs may vary depending upon the potential for exposure in
your workplace.


SECTION 4 - FIRST AID MEASURES

Skin Remove clothing and wash affected skin with soap and water. This
material may not be completely removed by conventional laundering.
Consult professional laundry service. Do not home launder. If irritation
occurs or persists, get medical attention.
Eyes Immediately flush eyes with water for at least 15 minutes. Get medical
attention. If irritation occurs or persists, get medical attention.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get
medical attention immediately.
Ingestion Get medical attention immediately. Do not induce vomiting unless directed
by medical personnel. Never give anything by mouth to an unconscious
person.


SECTION 5 - FIRE FIGHTING MEASURES

Wear approved positive pressure, self-contained breathing apparatus and
Fire fighting instructions
full protective turn out gear. Evacuate area and fight fire from a safe
distance.
Water, carbon dioxide, dry chemical or foam.
Extinguishing media
No data available
Flash point
Carbon monoxide and carbon dioxide
Hazardous combustion
products


SECTION 6 - ACCIDENTAL RELEASE MEASURES

Review Sections 3, 8 and 12 before proceeding with clean up.
General

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Use non-combustible material to absorb spill; then place in a suitable,
Small spill
labeled recovery container. Clean spill area thoroughly. Prevent discharge
to drains.
Large spill Contain the source of the spill or leak if it is safe to do so. Use absorbant
material to wipe up spill and place in a sealed container for disposal. Close
container and move it to a secure holding area. Prevent discharge to
drains.


SECTION 7 - HANDLING AND STORAGE

General handling Use only in a well-ventilated area. Avoid contact with eyes. Avoid contact
with skin and clothing. Wash thoroughly after handling.
Storage conditions Store in a cool, dry, well-ventilated area. Protect from light. Keep
container tightly closed when not in use.
Temperature range <30??C (<86??F)
for storage


SECTION 8 - EXPOSURE CONTROLS/PERSONAL PROTECTION

Engineering controls should be used as the primary means to control
Ventilation
exposures. Good general ventilation should be sufficient to control
airborne levels. Local and general ventilation should be used as necessary,
when handling this material in bulk.
Respiratory protection is recommended as a precaution to minimize
Respiratory protection
exposure when handling this material in bulk.
Safety glasses or goggles
Eye protection
Use protective clothing (uniforms, lab coats, disposable coveralls, etc.) in
Skin protection
both production and laboratory areas.
Rubber gloves
Hand protection


SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES

Paste
Physical form
White
Color
Odorless
Odor
Mixture
Molecular weight
Mixture
Molecular formula

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Not applicable
pH
Not applicable
Boiling point
Not applicable
Melting point
No data available
Density
No data available
Vapor pressure
No data available
Water solubility
No data available
Solvent solubility


SECTION 10 - STABILITY AND REACTIVITY

Stable
Reactivity
None known
Conditions to avoid
None known
Incompatibilities
Thermal decomposition products may include carbon monoxide and
Hazardous
carbon dioxide
decomposition
products
Will not occur
Hazardous
polymerization


SECTION 11 - TOXICOLOGY INFORMATION

The information included in this section describes the potential hazards of
Toxicology summary
the active ingredients.
Acute toxicity
Compound Type Route Species Result
Ivermectin LD50 Oral Rat 10 mg/kg
May cause eye irritation based on components.
Eye
May cause skin irritation based on components.
Skin
No data available
Inhalation
See Acute toxicity table.
Ingestion
Ivermection showed no evidence of mutagenic activity in bacterial or
Mutagenicity
mammalian cells in vitro.
No data available
Subchronic effects



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Chronic effects/ No carcinogenic data available. However, the carcinogenic potential of a
carcinogenicity structurally related avermectin, abamectin, has been investigated in
rodents. No evidence of carcinogenicity was seen in these studies.
None of the components of this formulation are listed as a carcinogen by
Carcinogen status
IARC, NTP or OSHA.
Ivermectin had no adverse effects on the fertility in rats in studies at
Reproductive effects
repeated doses of up to3 times the maximum recommended human dose of
200 ??g/kg.
Ivermectin has been shown to be teratogenic in rats, rabbits, and mice at or
Teratogenicity
near maternotoxic dose levels. Mice are the most sensitive species to the
effects of ivermectin with maternotoxicity at a dose of 200 ??g/kg/day and
teratogenicity at 400 ??g/kg/day. In rabbits 6000 ??g/kg/day was
maternotoxic and teratogenic, and teratogenicity was also evident at a dose
of 3000 ??g/kg/day. The threshold for both maternotoxicity and
teratogenicity in rats was 10,000 ??g/kg/day.


SECTION 12 - ECOLOGICAL INFORMATION

As with other members of the avermectin family, ivermectin is highly
Environmental overview
toxic to fish and certain aquatic organisms. However, once in contact with
soil, it is tightly bound and does not readily desorb. It is unlikely to reach
groundwater and is also biodegradable by soil microflora.
Avermectin compounds may bind tightly to soil upon contact and become
Mobility, persistence,
inactive over time.
and degradability:
See aquatic toxicity data, below.
Bioaccumulation and
toxicity:
Aquatic toxicity
Compound Type Species Result
Ivermectin LC50/48h Rainbow Trout 0.000025 mg/L


SECTION 13 - DISPOSAL INFORMATION

Incineration is the recommended method of disposal for this material.
Disposal procedure
Observe all local and national regulations when disposing of this mixture.


SECTION 14 - TRANSPORTATION INFORMATION

This material is regulated for transportation as a hazardous
General shipping
instructions material/dangerous good. Non-regulated in non-bulk packagings
transported by motor vehicles, rail cars or aircraft (49CFR 171.4(c)).

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Proper shipping name Environmentally Hazardous Substance, Solid, n.o.s (ivermectin), Marine
Pollutant
UN 3077
Identification number
9
Hazard class
III
Packing group


SECTION 15 - REGULATORY INFORMATION

EU Classification Toxic; Dangerous for the Environment
EU Labelling T
EU Label Pictogram(s)




R25 - Toxic if swallowed.
Risk phrases
R52/53 - Harmful to aquatic organisms, may cause long-term adverse
effects in the aquatic environment.
S36/37 - Wear suitable protective clothing and gloves.
Safety phrases
S45 - In case of accident or if you feel unwell seek medical advice
immediately (show the label where possible).
S61 - Avoid release to the environment. Refer to special instructions/safety
data sheets.
Class D, Division 1, Subdivision A
Canadian WHMIS
Class D, Division 2, Subdivision A


SECTION 16 - OTHE
Disclaimer Pfizer Inc believes that the information contained in this Material
Safety Data Sheet is accurate, and while it is provided in good faith, it
is without a warranty of any kind, expressed or implied.




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Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-