3,5,9-Trioxo-4-phosphaheptacosan-1-aminium,
7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, hydroxide,
inner salt, 4-oxide, (R)-

CAS  

 74389-69-8

SYNONYMS  

 * Blood platelet-activating factor
* C18-Paf
* C18-Paf-acether
* 1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
* PAF-acether
* Platelet-activating factor
* Platelet activating factor-acether
* Ro 14-8161
* 1-O-Stearoyl-2-acetyl-sn-glyceryl-3-phosphorylcholine

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : YK0715000
CHEMICAL NAME           : 3,5,9-Trioxo-4-phosphaheptacosan-1-aminium,
                          7-(acetyloxy)-4-hydroxy-N,N,N-trimethyl-, hydroxide,
                          inner salt, 4-oxide, (R)-
CAS REGISTRY NUMBER     : 74389-69-8
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C28-H58-N-O7-P
MOLECULAR WEIGHT        : 551.84
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * Blood platelet-activating factor
   * C18-Paf
   * C18-Paf-acether
   * 1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
   * PAF-acether
   * Platelet-activating factor
   * Platelet activating factor-acether
   * Ro 14-8161
   * 1-O-Stearoyl-2-acetyl-sn-glyceryl-3-phosphorylcholine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 243,378,1987
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 10 nmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 14,1289,1993
 
                            *** END OF RECORD ***