MATERIAL SAFETY DATA SHEET
XENON Xe 133 GAS

SECTION 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Name: Xenon Xe 133 Gas Revision Date: January 1, 2003
Synonyms: Xenon-133 Information Telephone Number: (888) 744-1414
Manufacturer: Mallinckrodt Inc. Emergency Telephone Number: (314) 654-7860
2703 Wagner Place CHEMTREC: 1-800-424-9300
Maryland Heights, MO 63043 CANUTEC: 613-996-6666

SECTION 2. COMPOSITION, INFORMATION ON INGREDIENTS
Chemical Formula: Xe-133

Chemical Ingredients:
Component CAS # Wt %
Xenon Xe 133 Gas 14932-42-4 <0.5%




SECTION 3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
CAUTION! RADIOACTIVE MATERIAL. Read Package Insert prior to use. Promptly remove any
contamination from the skin, eyes, or clothing. Radioactive drugs must be handled by qualified personnel
in conformity with regulations appropriate to the government agency authorized to license the use of this
radionuclide. The vial containing the drug should be kept within its container or within heavier shielding.
Avoid contact with the radioactive contents which would cause unnecessary exposure to radiation.

POTENTIAL HEALTH EFFECTS
Eye Contact:
Inhalation:
No adverse effect expected.
Not expected to be a health hazard via
inhalation.
Chronic Exposure:
Ingestion:
The health risks associated with chronic
Not applicable.
radiation exposure (cancer, leukemia, genetic
and teratogenic effects) are believed to involve
Skin Contact:
levels of radiation exposure which are much
Not expected to produce any acute adverse
higher than those permitted occupationally.
health effects.

Aggravation of Pre-existing Conditions:
No information found.




XENON Xe 133 GAS
 XENON Xe 133 GAS


SECTION 4. FIRST AID MEASURES
Inhalation: Skin Exposure:
Notify radiation safety personnel immediately. Not expected to require first aid measures.
The amount of material inhaled should be
Eye Exposure:
assessed and documented.
Not expected to require first aid measures.
Ingestion:
Not applicable.



SECTION 5. FIRE FIGHTING MEASURES
Fire: Not considered to be a fire hazard.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire.
Special Instructions: In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive
pressure mode.



SECTION 6. ACCIDENTAL RELEASE MEASURES
If the product is received in a leaking condition or any loss or release of the radioactive contents occurs,
notify your Radiation Safety Department and Mallinckrodt at (314) 654-7860. All cleanup operations
should be performed according to the Standard Operating Procedures (SOPs) established for your facility
and by the NRC or other applicable local, state or federal regulations.



SECTION 7. HANDLING AND STORAGE
Store at 15??C to 30??C. Handling time should be kept to a minimum and appropriate shielding should be
used. Special handling devices such as the Xenotron?? I Xenon Gas Dispenser, should be used. Storage
and disposal of product should be controlled in a manner which is in compliance with the appropriate
regulations of the federal and state government agency authorized to license the use of this radionuclide.



SECTION 8. EXPOSURE CONTROLS, PERSONAL PROTECTION
Airborne Exposure Limits: Respiratory Protection:
?CNRC Occupational concentration limit is Not expected to require personal respirator
1 x 10-4 ??Ci/mL of air. usage.
Engineering Controls: Skin Protection:
Ventilation systems should vent directly to the Not expected to require skin protection.
atmosphere and should move sufficient air to
Eye/Face Protection:
dilute the Xenon-133 to permissible
Not expected to require eye protection.
concentrations within the facility and outside the
facility. Precautions:
Rooms where Xenon-133 gas is used should
be kept under negative pressure with respect to
adjacent areas.



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SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Colorless gas sealed in a 2 mL Concentration: 5 or 10 mCi/mL on the calibration date
unit dose glass vial. and time.
Odor: Odorless. Specific Activity: >1mCi/??g of Xenon gas on the
calibration date and time.
Boiling Point: ??108??C @ 1 mm.
Half-Life: ca. 5.245 days.
Radioactivity: 10 or 20 mCi/vial on the
calibration date and time.



SECTION 10. STABILITY AND REACTIVITY
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: Inert gas; does not decompose.
Hazardous Polymerization: Will not occur.
Incompatibilities: No information found.



SECTION 11. TOXICOLOGICAL INFORMATION
It is widely accepted by the scientific community that exposure to sufficient quantities of ionizing
radiation can potentially cause harmful biological effects which include cancer, leukemia, and genetic
and teratogenic effects. For detailed toxicological information on specific components, write to the
address listed in Section 1 - Attn: Regulatory Compliance Department.



SECTION 12. ECOLOGICAL INFORMATION
Under ordinary conditions of use and storage, this product is expected to have no adverse
environmental impact.



SECTION 13. DISPOSAL CONSIDERATIONS
Xenon Xe 133 Gas is Radioactive Waste until the activity has decayed to nondetectable levels.
Radioactive waste must be handled in accordance with procedures established by your Radiation
Safety Officer, NRC and other applicable regulations.



SECTION 14. TRANSPORT INFORMATION
DOT (Department of Transportation):
Proper Shipping Name: Radioactive Material, n.o.s.
Hazard Class: 7
Identification Number: UN2982




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SECTION 15. REGULATORY INFORMATION
CERCLA Reportable Quantities:
Xe 133 = 1000 Ci (3.7 E 13 Bq)
Releases to air, land or water of these hazardous substances which exceed the Reportable Quantity
(RQ) must be reported to the National Response Center at 800-424-8802.
SARA Title III
302 Extremely Hazardous Substances: None
311/312 Hazard Categories: Chronic
313 Toxic substances subject to annual release reporting requirements: None.
RCRA Hazardous Waste Status
Non-hazardous (See Section 13 for additional details.)
California Proposition 65 Warning
This product contains a substance known to the State of California to cause cancer.
Australian Hazchem Code: None allocated.
Australian Poison Schedule: None allocated.
WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.



SECTION 16. OTHER INFORMATION
MSDS Status: Revised in accordance with ANSI Guideline Z400.1-1998
NFPA Ratings: Health: 1 Flammability: 0 Reactivity: 0
Product Use: Diagnostic imaging agent
Revision Information: Section 8 updated.




Mallinckrodt provides the information contained herein EXPRESS OR IMPLIED, INCLUDING WITHOUT
in good faith but makes no representation as to its LIMITATION ANY WARRANTIES OF MERCHANT-
comprehensiveness or accuracy. This document is ABILITY, FITNESS FOR A PARTICULAR PURPOSE
intended only as a guide to the appropriate WITH RESPECT TO THE INFORMATION SET
precautionary handling of the material by a properly FORTH HEREIN OR THE PRODUCT TO WHICH
trained person using this product. Individuals receiving THE INFORMATION REFERS. ACCORDINGLY,
the information must exercise their independent MALLINCKRODT WILL NOT BE RESPONSIBLE
judgment in determining its appropriateness for a FOR DAMAGES RESULTING FROM USE OF O particular purpose. MALLINCKRODT MAKES NO RELIANCE UPON THIS INFORMATION.
REPRESENTATIONS OR WARRANTIES, EITHE



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