MSDS: .gamma.-Tocopherol Metabolite 2/27/02 5:07 PM




MATERIAL SAFETY DATA SHEET

This form complies with OSHA's Hazard Communication Standard, 29 CFR 1910.1200.
IDENTITY (As Used on Label and List): .gamma.-Tocopherol Metabolite


SECTION I - Product Identification
.gamma.-Tocopherol Metabolite


Manufacturer Name and Address: Telephone Numbers:
Cayman Chemical Company Cayman Chemical (800)364-9897
1180 E. Ellsworth Rd.
Ann Arbor, MI. 48108 Cayman Chemical (734)971-3335

Date Entered: 09/28/97 Last Revision: 08/10/99 MSDS Printed: 10/01/99

Synonyms:
GTM; 3,4-dihydro-6-hydroxy-2,7,8-trimethyl-2H-1-benzopyran-2-propanoi c acid

Chemical Family: Natriuretic factor
Hazard Label:
Molecular Formula: C15H20O4 Molecular Weight: 264.30

NFPA Ratings: (0-4) NFPA Specific Hazards
Health: 2
Flammability: 0
Reactivity: 0




SECTION II - Hazardous Ingredients/Identity Information
.gamma.-Tocopherol Metabolite


Hazardous Components (Specific Chemical Identity/Common Name) CAS #
.gamma.-Tocopherol Metabolite 178167-75-4

CAS # OSHA PEL ACGIH TLV Other Limits Percentage
178167-75-4 100.0




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SECTION III - Physical/Chemical Characteristics
.gamma.-Tocopherol Metabolite


Boiling Point: . . . NE or NA
Melting Point: . . . 147.0C to: 148.0C
Specific Gravity: . . . NE or NA (Water = 1)
Vapor Pressure: . . . NE or NA (mm Hg)
Vapor Density: . . . NE or NA (Air = 1)
Physical States: . . . [ ] Gas , [ ] Liquid , [ X ] Solid
Evaporation Rate: . . . NE or NA (Butyl Acetate = 1)
Solubility In Water: . . . NE or NA
Percent Volatile: . . . NE or NA

Appearance and Odor:
A crystalline solid.



SECTION IV - Fire and Explosion Hazard Data
.gamma.-Tocopherol Metabolite


Flash Pt: NE or NA Method Used:
Explosive Limits: LEL: UEL: Autoignition Pt: NE or NA

Extinguishing Media:
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.

Special Fire Fighting Procedures:

Unusual Fire and Explosion Hazards:



SECTION V - Reactivity Data
.gamma.-Tocopherol Metabolite


Stability: Unstable [ ] Stable [ X ]

Conditions To Avoid - Instability:

Incompatibility - Materials To Avoid:

Hazardous Decomposition Or Byproducts:

Hazardous Polymerization: May occur [ ] Will not occur [ X ]

Conditions To Avoid - Hazardous Polymerization:




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SECTION VI - Health Hazard Data
.gamma.-Tocopherol Metabolite


Route(s) of Entry: Inhalation? Yes , Skin? Yes , Eyes? Yes , Ingestion? Yes
Other:

Health Hazards (Acute and Chronic):
Contact may cause skin or eye irritation. The toxicological properties of this compound have not been fully evaluated.

Carcinogenicity: NTP? No , IARC Monographs? No , OSHA Regulated? No

Carcinogenicity/Other Information:

Recommended Exposure Limits:
LD 50/LC 50:

Signs and Symptoms Of Exposure:
Irritating to the skin, eyes, nose, throat, and respiratory tract.

Medical Conditions Generally Aggravated By Exposure:

Emergency and First Aid Procedures:
If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get immediate
medical attention. If swallowed, wash out mouth with water provided person is conscious. Never give anything by mouth
to an unconscious person. Get medical attention. In case of contact with eyes, hold eyelids apart and flush eyes with plenty
of water. After initial flushings, remove any contact lenses and continue flushing for at least 15 minutes. Have eyes examined
and tested by medical personnel. In case of skin contact, immediately wash skin with soap and plenty of water. Remove
contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse.



SECTION VII - Precautions for Safe Handling and Use
.gamma.-Tocopherol Metabolite



Steps To Be Taken In Case Material Is Released Or Spilled:
Vacuum or sweep up material and place in disposal container. After removal, flush the contaminated area thoroughly with

Waste Disposal Method:
Dispose in accordance with local, state and federal regulations.

Hazard Label Information: Avoid contact with skin and eyes. Do not reuse this container. Use with adequate ventilation.
Wash thoroughly after handling.

Precautions To Be Taken in Handling and Storing:
Avoid contact with eyes, skin, and clothing. Do not reuse this container. Store at correct temperature. Use with adequate
ventilation. Wash thoroughly after handling.

Other Precautions:




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SECTION VIII- Control Measures
.gamma.-Tocopherol Metabolite


Protective Equipment Summary - Hazard Label Information Eye wash station in work area Lab coat Latex disposable
gloves Safety glasses Safety shower in work area Vent Hood

Respiratory Equipment (Specify Type):

Ventilation:
Good general ventilation should be sufficient to control airborne levels.

Eye Protection:
Safety glasses

Protective Gloves:
Latex disposable gloves

Other Protective Clothing:
Lab coat

Work/Hygienic/Maintenance Practices:
Do not take internally. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety
shower. Wash thoroughly after handling.



SECTION IX - Additional Comments
.gamma.-Tocopherol Metabolite



For research use only, not for human or veterinary clinical use.

For research use only, not for human or veterinary clinical use. DISCLAIMER:
This information is believed to be accurate and represents the best information currently available to us. However, we
make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we
assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes.




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2,7,8-TRIMETHYL-2-(BETA-CARBOXY-ETHYL)-6-HYDROXYCHROMAN