Conforms to 93/112/EC and ISO 11014-1


SAFETY DATA SHEET
Order Number Customer Number


Identification of the substance/preparation and of the company/undertaking
1.
Benzoyl-Arg-OMe . HCl : 04-12-5211
Product name : Catalog #
: Manufactured by Merck Biosciences AG
Supplier
Weidenmattweg 4
.
Chemical formula C14H20N4O3 HCl
: CH-4448 L?ufelfingen
Switzerland
+41 62 285 2525
FAX: +41 62 285 2520
EMD Biosciences, Inc.
P.O. Box 12087
La Jolla, CA 92039-2087
(858) 450-5558/(800) 854-3417
FAX: (858) 453-3552

BAME hydrochloride;
Synonym :
N-alpha-Benzoyl-L-arginine methyl ester hydrochloride



Emergency : Call Chemtrec?
telephone number (800)424-9300 (within U.S.A.)
(703)527-3887 (outside U.S.A.)


Composition / information on ingredients
2.
: Substance
Substance/Preparation

Chemical name* CAS No. EC Number Symbol R-Phrases
BAME hydrochloride; 1784-04-9 Not available. - -
N-alpha-Benzoyl-L-arginine methyl ester hydrochloride


Hazards identification
3.
: Not applicable.
Physical/chemical hazards
: No specific hazard.
Human health hazards




First-aid measures
4.
First-Aid measures
: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
Inhalation
attention.
: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
Ingestion
person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a
collar, tie, belt or waistband.
: In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
Skin Contact
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention.

: Repeated or prolonged exposure is not known to aggravate medical condition.
Aggravating conditions



5. Fire-fighting measures
: May be combustible at high temperature.
Flammability of the Product
Extinguishing Media
: SMALL FIRE: Use DRY chemical powder.
Suitable
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds, hydrogen chloride.
Hazardous thermal (de)composition
products

: Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear.
Special fire-fighting procedures
: Be sure to use an approved/certified respirator or equivalent.
Protection of fire-fighters



04-12-5211
Catalog #
 Accidental release measures
6.
: Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist
Personal precautions
BEFORE handling this product.
: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Small Spill and Leak


: Use a shovel to put the material into a convenient waste disposal container.
Large Spill and Leak



Handling and storage
7.
: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under
Handling
a fume hood. Ground all equipment containing material. Do not breathe dust.
: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 4??C (39.2??F).
Storage
Packaging materials
: Use original container.
Recommended use


Exposure controls/personal protection
8.
: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering measures
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
: Wash hands after handling compounds and before eating, smoking, using lavatory, and at the end of day.
Hygiene measures
Ingredient Name Occupational Exposure Limits
Benzoyl-Arg-OMe . HCl Not available.


Personal protective equipment
: Lab coat.
Skin and body
: Safety glasses.
Eyes
Protective Clothing (Pictograms) :




Physical and chemical properties
9.
: Solid.
Physical state
Color : Not available.
: 328.8 g/mole
Molecular Weight

: Not available.
Solubility
Flash point : Not available.
: Risks of explosion of the product in presence of mechanical impact: Not available.
Explosive properties
Risks of explosion of the product in presence of static discharge: Not available.



10. Stability and reactivity
: The product is stable.
Stability
: Hygroscopic; keep container tightly closed.
Conditions to avoid
: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds, hydrogen chloride.
Hazardous Decomposition Products



11. Toxicological information
RTECS # : N/A
Local effects
Skin irritation : Not available.
: LD50: Not available.
Acute toxicity
LC50: Not available.
: Repeated or prolonged exposure is not known to aggravate medical condition.
Chronic toxicity
: Not available.
Other Toxic Effects on Humans
No specific information is available in our database regarding the other toxic effects of this material for humans.

Not available.




04-12-5211
Catalog #
 To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated.


Carcinogenic effects : Not available.
: Not available.
Mutagenic effects
Reproduction toxicity : Not available.
: Not available.
Teratogenic effects


12. Ecological information
: Not available.
Ecotoxicity
: The products of degradation are more toxic than the product itself.
Toxicity of the Products of
Biodegradation


13. Disposal considerations
: Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Methods of disposal; Waste of residues;
Contaminated packaging



14. Transport information
International transport regulations
Land - Road/Railway
: Not controlled under ADR (Europe).
ADR/RID Class
Sea
: Not controlled under IMDG.
IMDG Class
Air
: Not controlled under IATA.
IATA-DGR Class
Not applicable.
Special Provisions for
Transport


15. Regulatory information
EU Regulations
: This product is not classified according to the EU regulations.
Risk Phrases
U.S. Federal Regulations : TSCA: No products were found.
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found.
SARA 313 toxic chemical notification and release reporting: No products were found.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
: Not controlled under the HCS (United States).
HCS Classification

State Regulations :


: Not controlled under WHMIS (Canada).
WHMIS (Canada)
No products were found.


16. Other information
Hazardous Material 0 National Fire
Health
Fire Hazard
1
Information System Protection Association
1
Fire Hazard
(U.S.A.) (U.S.A.) 0 0
Health Reactivity
0
Reactivity
Specific Hazard
A
Personal Protection
Personal Protection

Notice to Reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any
liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with
caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. **This product is intended for research
use only.**




04-12-5211
Catalog #
 04-12-5211
Catalog # Date of issue 8/13/2003.


L-BAME