MATERIAL SAFETY DATA SHEET
TechneScan?? PYP??
Technetium Tc99m Pyrophosphate

SECTION 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
Product Name: TechneScan?? PYP?? Revision Date: January 1, 2003
Synonyms: Tc99m PYP; Tc99m Pyrophosphate. Information Telephone Number: (888) 744-1414
Manufacturer: Mallinckrodt Inc. Emergency Telephone Number: (314) 654-7860
2703 Wagner Place CHEMTREC: 1-800-424-9300
Maryland Heights, MO 63043 CANUTEC: 613-996-6666

SECTION 2. COMPOSITION, INFORMATION ON INGREDIENTS
Chemical Ingredients:
Component CAS # Wt %
Sodium Pyrophosphate 7722-88-5 75.8%
Stannous Chloride 7772-99-8 24.2%
Reconstituted Kit
Technetium-99m 23288-60-0




SECTION 3. HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Read Package Insert prior to use! Promptly remove any contamination from skin, eyes, or clothing. Avoid
all unnecessary exposure to the chemical substance.

POTENTIAL HEALTH EFFECTS
Skin Contact:
The hazardous ingredients found in TechneScan
Not expected to be a health hazard.
PYP are skin and eye irritants, but due to the
small quantities present in each container, no
Eye Contact:
adverse health effects are expected to occur
Not expected to be a health hazard.
from exposure.

Chronic Exposure:
Inhalation:
Not expected to be a chronic health hazard.
Not expected to be a health hazard.

Aggravation of Pre-existing Conditions:
Ingestion:
No information found.
Not expected to be a health hazard.




TechneScan?? PYP??
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SECTION 4. FIRST AID MEASURES
Inhalation: Skin Exposure:
Not expected to require first aid measures. Wash exposed area with soap and water. Get
medical advice if irritation develops.
Ingestion:
Not expected to require first aid measures. Eye Exposure:
Wash thoroughly with running water. Get
medical advice if irritation develops.

SECTION 5. FIRE FIGHTING MEASURES
Fire: Not considered to be a fire hazard.
Explosion: Not considered to be an explosion hazard.
Fire Extinguishing Media: Use any means suitable for extinguishing surrounding fire.
Special Instructions: In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive
pressure mode.

SECTION 6. ACCIDENTAL RELEASE MEASURES
Collect non-radioactive spills and dispose of material as non-hazardous waste. For TechneScan?? PYP
Reconstituted with Sodium Pertechnetate Tc-99m: If any loss or release of the radioactive contents
occurs, notify your Radiation Safety Department and Mallinckrodt at (314) 654-7860. All cleanup
operations should be performed according to the Standard Operating Procedures (SOPs) established for
your facility and by the NRC or other applicable local, state or federal regulations.



SECTION 7. HANDLING AND STORAGE
The drug should be stored at 2??C to 8??C before reconstitution with Sodium Pertechnetate Tc-99m. After
reconstitution, the shielded vial should be stored at 15??C to 30??C and discarded after six (6) hours from
the time of preparation. Handling time should be kept to a minimum and appropriate shielding should be
used. Handling devices such as syringe shields and tongs should be used. Storage and disposal of
product should be controlled in a manner that is in compliance with the appropriate regulations of the
government agency authorized to license the use of this radionuclide.



SECTION 8. EXPOSURE CONTROLS, PERSONAL PROTECTION
Airborne Exposure Limits: Engineering Controls:
Not expected to require any special ventilation.
For Tin Compounds: Respiratory Protection:
?COSHA Permissible Exposure Limit (PEL): Not expected to require personal respirator
2 mg/m3 (TWA), as Sn usage.
?CACGIH Threshold Limit Value (TLV):
Skin Protection:
2 mg/m3 (TWA), as Sn
Wear protective gloves and clean
For Tetrasodium Pyrophosphate: body-covering clothing.
?CACGIH Threshold Limit Value (TLV):
Eye/Face Protection:
5 mg/m3 (TWA)
Safety glasses.




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SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Small, dry, white crystals clinging Boiling Point: ca. 100??C (212??F) reconstituted.
to inside of a 10 mL glass vial.
Melting Point: ca. 0??C (32??F) reconstituted.
Odor: Odorless.
Solubility: Soluble in water.




SECTION 10. STABILITY AND REACTIVITY
Stability: Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products: When heated to decomposition, substance may emit oxides of
carbon and corrosive fumes of hydrochloric acid.
Hazardous Polymerization: Will not occur.
Incompatibilities: No information found.



SECTION 11. TOXICOLOGICAL INFORMATION
For detailed toxicological information on specific components, write to the address listed in Section 1 -
Attn: Regulatory Compliance Department.



SECTION 12. ECOLOGICAL INFORMATION
Because this product is intended for use by hospital or clinic patients, it is expected to be treated by
standard wastewater treatment facilities with no adverse environmental impacts.



SECTION 13. DISPOSAL CONSIDERATIONS
TechneScan?? PYP reconstituted with Sodium Pertechnetate Tc-99m is Radioactive Waste until the
activity has decayed to nondetectable levels. Radioactive waste must be handled in accordance with
procedures established by your Radiation Safety Officer, NRC and other applicable regulations.
If medical waste is involved, such as blood, blood products, or sharps, the waste must be handled as a
Biohazard and disposed of accordingly.
If not radioactive or a biohazard, waste TechneScan PYP is considered non-hazardous. Consult local,
state and federal regulations for proper disposal.


SECTION 14. TRANSPORT INFORMATION
DOT (Department of Transportation): Not Regulated




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SECTION 15. REGULATORY INFORMATION
CERCLA Reportable Quantities:
Tc-99m = 100 Ci (3.7 E 12 Bq)
Releases to air, land or water of these hazardous substances which exceed the Reportable Quantity
(RQ) must be reported to the National Response Center at 800-424-8802.
SARA Title III
302 Extremely Hazardous Substances: None
311/312 Hazard Categories: None
313 Toxic substances subject to annual release reporting requirements: None.
RCRA Hazardous Waste Status
Non-hazardous (See Section 13 for additional details.)
California Proposition 65 Warning
When this kit is reconstituted with radioactive material, this product contains a substance known to the
State of California to cause cancer.
Australian Hazchem Code: None allocated.
Australian Poison Schedule: None allocated.
WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products
Regulations (CPR) and the MSDS contains all of the information required by the CPR.

SECTION 16. OTHER INFORMATION
MSDS Status: Revised in accordance with ANSI Guideline Z400.1-1998
NFPA Ratings: Health: 0 Flammability: 0 Reactivity: 0
Product Use: Diagnostic imaging agent
Revision Information: No changes.




Mallinckrodt provides the information contained herein EXPRESS OR IMPLIED, INCLUDING WITHOUT
in good faith but makes no representation as to its LIMITATION ANY WARRANTIES OF MERCHANT-
comprehensiveness or accuracy. This document is ABILITY, FITNESS FOR A PARTICULAR PURPOSE
intended only as a guide to the appropriate WITH RESPECT TO THE INFORMATION SET
precautionary handling of the material by a properly FORTH HEREIN OR THE PRODUCT TO WHICH
trained person using this product. Individuals receiving THE INFORMATION REFERS. ACCORDINGLY,
the information must exercise their independent MALLINCKRODT WILL NOT BE RESPONSIBLE
judgment in determining its appropriateness for a FOR DAMAGES RESULTING FROM USE OF O particular purpose. MALLINCKRODT MAKES NO RELIANCE UPON THIS INFORMATION.
REPRESENTATIONS OR WARRANTIES, EITHE



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Sodium Pertechnetate Tc 99m