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Cas Database |
| Name |
Pramiracetam |
EINECS | 806-175-7 |
| CAS No. | 68497-62-1 | Density | 1.036 g/cm3 |
| PSA | 52.65000 | LogP | 1.17260 |
| Solubility | N/A | Melting Point |
47-48° |
| Formula | C14H27N3O2 | Boiling Point | 461 °C at 760 mmHg |
| Molecular Weight | 269.387 | Flash Point | 232.6 °C |
| Transport Information | N/A | Appearance | white crystalline powder |
| Safety | Risk Codes | 22 | |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
Amacetam;Vinpotropil; |
Article Data | 7 |
Pramiracetam Synthetic route
| Conditions | Yield |
|---|---|
| Stage #1: 2-pyrrolidinon With sodium methylate In toluene at 105 - 108℃; for 3h; Stage #2: N-[2-(di(isopropyl)amino)ethyl]-2-chloroacetamide In toluene at 60 - 70℃; | 89.49% |
- 61516-73-2
2-(oxo-pyrrolidin-1-yl)-acetic acid ethyl ester
- 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine
- 68497-62-1
pramiracetam
| Conditions | Yield |
|---|---|
| at 100℃; for 16h; | 69% |
- 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine
- 68497-62-1
pramiracetam
| Conditions | Yield |
|---|---|
| at 110℃; for 11h; Inert atmosphere; |
- 121-05-1
N',N'-diisopropyl-ethane-1,2-diamine
- 68497-62-1
pramiracetam
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: tetrahydrofuran / 1.67 h / 0 - 15 °C 2.1: sodium methylate / toluene / 3 h / 105 - 108 °C 2.2: 60 - 70 °C View Scheme |
- 68497-62-1
pramiracetam
| Conditions | Yield |
|---|---|
| With water In cyclohexane at 20 - 50℃; for 1.5h; Solvent; | 90.92% |
- 68497-62-1
pramiracetam
| Conditions | Yield |
|---|---|
| With sulfuric acid In acetonitrile at 0 - 5℃; | 84.83% |
Pramiracetam Chemical Properties
IUPAC Name: N-[2-[di(propan-2-yl)amino]ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
Synonyms of 1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo- (CAS NO.68497-62-1): Pramiracetam [INN] ; Pramiracetam ; Pramiracetamum ; Pramiracetamum [INN-Latin] ; UNII-4449F8I3LE
CAS NO: 68497-62-1
Molecular Formula of 1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo- (CAS NO.68497-62-1): C14H27N3O2
Molecular Weight: 269.3831
Molecular Structure:
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H bond acceptors: 5
H bond donors: 1
Freely Rotating Bonds: 7
Polar Surface Area: 43.86 Å2
Index of Refraction: 1.495
Molar Refractivity: 75.79 cm3
Molar Volume: 259.8 cm3
Surface Tension: 38.7 dyne/cm
Density of 1-Pyrrolidineacetamide,N-[2-[bis(1-methylethyl)amino]ethyl]-2-oxo- (CAS NO.68497-62-1): 1.036 g/cm3
Flash Point: 232.6 °C
Enthalpy of Vaporization: 72.18 kJ/mol
Boiling Point: 461 °C at 760 mmHg
Vapour Pressure: 1.11E-08 mmHg at 25°C
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