100% Natural Ursolic Acid 77-52-1 For Antitumor CAS NO.77-52-1

Min.Order Quantity:: 10 Gram

Purity:: 99%

Port:: Wuhan

Payment Terms:: T/T,MoneyGram

Add to Inquiry Cart

Product Details

Keywords

100% Natural Ursolic Acid
Ursolic Acid Manufacturer
For Antitumor

Quick Details

ProName: 100% Natural Ursolic Acid 77-52-1 For ...
CasNo: 77-52-1
Molecular Formula: C30H48O3
Appearance: White Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

Superiority

advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.

1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.

2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.

3. discreet package safelyand professionally disguised package guaranteed. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.

4. warm after-sale service any of your question would be solved for the first as soon as possible.

Details

ursolic acid basic information

overview plant sources antitumor effect determination of ursolic acid content of plant

product name:	ursolic acid
synonyms:	3beta-hydroxy-12-ursen-28-ic acid;3beta-hydroxy-12-ursen-28-oic acid;3b-hydroxyurs-12-en-28-oic acid;3beta-hydroxyurs-12-en-28-oic acid;(1s,2r,4as,6as,6br,8ar,10s,12ar,12br,14bs)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid;malol;prunol;sage extract
cas:	77-52-1
mf:	c30h48o3
mw:	456.7
einecs:	201-034-0
product categories:	pentacyclic triterpenes;tri-terpenoids;organics;chiral;natural plant extract;intermediates & fine chemicals;pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from chinese medicinal herbs (tcm).;standardized herbal extract;antineoplastic;natural product;plant extract;inhibitors;triterpenoids;oleanolic acid;ursolic acid
mol file:	77-52-1.mol

ursolic acid chemical properties

melting point	292 °c (dec.)(lit.)
alpha	59 º (c=0.3, pyridine)
storage temp.	2-8°c
form	crystalline powder or needles
color	white to off-white
water solubility	insoluble
merck	14,9890
cas database reference	77-52-1(cas database reference)
epa substance registry system	urs-12-en-28-oic acid, 3-hydroxy-, (3.beta.)-(77-52-1)

safety information

hazard codes	xi
risk statements	36/37/38
safety statements	24/25-36-26
wgk germany	-
rtecs	yu9520000
f	10-23

ursolic acid usage and synthesis

overview	ursolic acid is a kind of pentacyclic triterpenoids extracted from azaleas evergreen shrubs bearberry. it has a special smell. it exhibits big and shiny prism in absolute ethanol, and exhibits fine hair-like needle crystal in dilute ethanol. its m.p is 285 °c~288 °c, [α] d20 + 66 ° (pyridine). it is highly soluble in dioxane, pyridine, soluble in methanol, ethanol, butanol, and methyl ethyl ketone, slightly soluble in acetone, slightly soluble in benzene chloroform, and ethyl ether, but insoluble in water and petroleum ether. it has various kinds of biological effects including sedation, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar. in recent years, we found that it has the ability of anti-carcinogenic, anti-tumor promoters, inducing f9 teratoma cells differentiation and anti-angiogenesis, making it likely to become a promising novel anti-cancer drug of low toxicity and high efficiency. in addition, ursolic acid has significant antioxidant function and is a strong antioxidant. the anti-oxidation effect of ursolic acid has a positive effect on the body's anti-aging, alleviating skin spot, and pigment elimination, which is thus widely used as the raw materials of medicine and natural whitening cosmetics. there has been experiment showing that ursolic acid can inhibit the activity of 5-lipoxygenase and cyclooxygenase during the metabolism of arachidonic acid to prevent the biosynthesis of prostaglandins and leukotrienes, which may be mechanism through which ursolic acid can inhibit inflammation reaction and inhibit lipid peroxides reasons.
plant sources	ursolic acid is widely distributed in the plant kingdom. a various kinds of plants including traditional chinese medicine hawthorn, dogwood, diffusa, gardenia, plantago asiatica, prunella vulgaris all contain ursolic acid. as either a free form or be in the form glycosides through binding with sugar, it is distributed among about 62 kinds of plants from 7 families and 46 genera. it is mainly presented in the leaves of oleaceae plant privet, ericaceae bearberry, leaves of rosaceae loquat, leaves of scrophulariaceae paulownia tomentosa, the full grass of labiatae prunella, and also the leaves of aquifoliaceae llex rotunda.
antitumor effect	ursolic acid can also fight against various kinds of carcinogens and tumor promoters. studies have found that ursolic acid can significantly inhibit the proliferation of hl-60 cell and induce its apoptosis; can significantly improve the function of the mouse macrophage; can inhibit the proliferation of human tongue squamous carcinoma cell line tscca cell with the ld50 being 12.5umol • l-1 as well as exhibiting a dose-dependent efficacy relationship within 24h; situ hybridizations assay showed that the inhibitory effect of ursolic acid on tscca cells in vitro is related to the in situ inhibition of the expression of nuclear transcription factor. in vivo tests have demonstrated that ursolic acid can significantly enhance immune function, clarifying the broad anti-tumor effect of ursolic acid. from this perspective, ursolic acid is very likely to become a new anti-cancer drug with low toxicity and high efficiency.
determination of ursolic acid content of plant	(1) chromatographic conditions: silica gel g plate; cyclohexane-chloroform-ethyl acetate (20: 5: 8) as the developer agent, apply ascending development with development gap being from 12~18cm; 5% sulfuric acid in ethanol; apply 110 °c heating for 5min for colorimetric reaction. (2) the preparation of the reference solution: accurately weigh a certain amount of ursolic acid reference substance; add the mixed solution of absolute ethanol: ethanol (32) to prepare to solution of 1 mg/ml as the reference solution. (3) preparation of the sample solution: accurately weigh gardenia pulverized sample 20g (for fried gardenia, calculate after being normalized with the yield) and put it into the soxhlet extractor, add 300 ml ether for reflux extraction to being colorless; recycle solvent to dryness with the residue being added petroleum ether for soaking for 2 times (15ml each time), soak for about 2min, pour out the petroleum ether, apply anhydrous ethanol-ethyl ether (2: 3) mixture for micro heating to dissolve it and make constant volume solution in 5ml flask as the sample solution. (4) determination: accurately pipette 2 μl of sample solution and reference solution 2 into the same tlc plate. develop them according to the chromatographic conditions and start colorimetric reaction. scan it according to tlc scanning method, λs = 520nm, λr = 700nm; apply dual wavelength reflection zigzag scanning; sx = 3.0; slit: 1.20mm × 1.2mm; paper speed: 20mm/min. measure the integral value of absorption of both the sample and the reference substance for calculating the absolute amount of ursolic acid. the above information is edited by the chemicalbook of dai xiongfeng.
chemical properties	white to light yellow crystal powde
uses	a triterpene acid used in cosmetics, that also has stat3 pathway inhibiting properties.