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HENAN SUNLAKE ENTERPRISE CORPORATION137071-32-0 C43H68ClNO11 Pimecrolimus//file1.lookchem.com/cas/reactions/2021/07/02/8468581.png
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137071-32-0 C43H68ClNO11 Pimecrolimus CAS NO.137071-32-0

Min.Order Quantity:
1 Kilogram
Purity:
99%
Port:
Shanghai/Tianjin/Qingdao
Payment Terms:
L/C,D/A,D/P,T/T,

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Product Details

Keywords

  • SDZ-ASM 981
  • Elidel
  • oxaazacyclotricosine

Quick Details

  • ProName: 137071-32-0 C43H68ClNO11 Pimecrolimu...
  • CasNo: 137071-32-0
  • Molecular Formula: C43H68ClNO11
  • Appearance: White Solid
  • Application: 137071-32-0 ...
  • DeliveryTime: 7-10 days after payment
  • PackAge: As required
  • Port: Shanghai/Tianjin/Qingdao
  • ProductionCapacity: 100-200 Kilogram/Month
  • Purity: 99%
  • Storage: Store at -20°C
  • Transportation: By air/sea/express
  • LimitNum: 1 Kilogram
  • Grade: Pharma Grade

Superiority

about certificate

1.certificate of analysis (coa)
2.material safety data sheet (msds)
3.route of synthesis (ros)
4.method of aanlysis(moa)
5.nuclear magnetic resonance(nmr)

about service

1. quality control, before shipment, free sample for test.
2. prompt shipment with professional documents
3. packing as your request, with photo before shipment
4. mixed containers with different mixed items in one container

about company

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.
we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.
we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.
we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

product name: pimecrolimus
synonyms: picrolimus;asm 981;elidel;sdz-asm 981;pimecrolimus;15,19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone, 3-((1e)-2-((1r,3r,4s)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3s,4r,5s,8r,9e,12s,14s,15r,16s,18r,19r,26as)-;15,19-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4h,23h)-tetrone, 3-(2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3s-(3r*(e(1s*,3s*,4r*)),4s*,5r*,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-;unii-7kyv510875
cas: 137071-32-0
mf: c43h68clno11
mw: 810.459
einecs:
product categories: chiral reagents;intermediates & fine chemicals;pharmaceuticals;elidel, sdz-asm-981;inhibitors
mol file: 137071-32-0.mol
pimecrolimus structure
pimecrolimus chemical properties
density 1.19
storage temp. -20°c freezer
safety information
msds information
pimecrolimus usage and synthesis
topical immunomodulators pimecrolimus is a topical immunomodulators and is a kind of semi-synthetic products of the streptomyces-produced ascomycin. it has a greater lipophilicity than tacrolimus with a stronger affinity with the skin. it can effectively and safely control the signs and symptoms of facial seborrheic dermatitis and can quickly relieve the itching symptoms of patients with dermatitis and eczema as well as reduce the lesion area, clear atopic dermatitis (eczema) sign. therefore, it is an effective treatment method for the treatment of atopic dermatitis (eczema) for both early remission purpose and long-term control purpose.
seborrheic dermatitis is the body's immune inflammatory response to lipophilic malassezia. both the humoral and cellular immunity participate in the sickening process. pimecrolimus can selectively inhibit the activation of t cell through inhibiting the activity of the calcium-dependent nerve transcription proteins which is indispensible for the activation of t cells and prevent the release of cytokines and pro-inflammatory mediator, and further exhibiting strong anti-inflammatory activity. these results suggest that the mechanism of pimecrolimus for treatment of seborrheic dermatitis comes from its anti-inflammatory effect and immune regulation. currently there have been no reports regarding on its direct participation of antifungal activity. but in recent years, there have been reports finding that tacrolimus (a kind of immunomodulatory agents with similar chemical structure and mechanisms as pimecrolimus) have some anti-malassezia activity.
similar as the tacrolimus, pimecrolimus is a cellular selective inhibitor which is produced and released by the pro-inflammatory cytokine and can combine with macrophilin 12 (fkbp-12) to inhibit of calcium-dependent calcineurin as well as suppress the t-cell activation through blocking the early cytokines transcription of t cells. in particular, a level of nanogram is enough to suppress the synthesis of t cell il-2 and ifn-γ (th1 cell origin) factor and can also inhibit the synthesis of il-4 and il (th2 cell-derived). in addition, in vitro experiments, pimecrolimus can also be applied to inhibit the antigen as well as ige stimulated mast cells’ release of inflammatory cytokines and inflammatory mediators [4, 5]. clinical data have shown that after topical application, the blood concentration is very low and is usually under the detected value (<0.5 ng / ml). it also has no drug accumulation phenomenon.
the above information is edited by the chemicalbook of dai xiongfeng.
chemical properties white solid
usage pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. pimecrolimus has been targeted for treatment of inflammatory skin disorders. like all tacrolimus analogues, pimecrolimus binds to receptor protein, fkbp12. the complex then binds to mtor preventing it from interacting with target proteins. pimecrolimus is extensively cited in the literature with over 2,000 citations.
usage macrolactam ascomycin derivative; inhibits production of pro-inflammatory cytokines by t cells and mast cells. immunosuppresant
usage pimecrolimus caused a strong and dose-dependent inhibition of anti-ige–induced release of histamine from mast cells and basophils (maximally 73% and 82%, respectively, at 500 nmol/l pimecrolimus) and of mast cell tryptase (maximally 75%) and a less pronou
pimecrolimus preparation products and raw materials

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