162359-56-0 C19H34ClNO2 Fingolimod hydrochloride CAS NO.162359-56-0

fingolimod hydrochloride basic information

oral drug for the treatment of multiple sclerosis

product name:	fingolimod hydrochloride
synonyms:	fingolimod hydrochloride;fty720;2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;fingolimod hcl;fty720 hydrochloride;2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol,hcl;fingolimod hcl(fty720)
cas:	162359-56-0
mf:	c19h34clno2
mw:	343.93
einecs:
product categories:	all inhibitors;inhibitors;metabolites;pharmaceutical intermediate;pharmaceuticals;aromatics;intermediates & fine chemicals;metabolites & impurities;api;other apis
mol file:	162359-56-0.mol

fingolimod hydrochloride chemical properties

mp	102-107°c
storage temp.	-20°c freezer
cas database reference	162359-56-0(cas database reference)

safety information

hazard codes	xi
risk statements	36/37/38-52/53
safety statements	26-61

msds information

fingolimod hydrochloride usage and synthesis

oral drug for the treatment of multiple sclerosis	fingolimod hydrochloride is the first oral drug for the treatment of multiple sclerosis. it is successfully developed by the pharmaceutical company novartis, and it has been approved for marketing by the us food and drug administration (fda). the recommended dose is 0.5mg once a day for oral administration. multiple sclerosis is a debilitating neurological disease that can cause the patient to lose a sense of balance, appear muscle spasms and other movement disorders. the disease has been treated with injectable drugs. this kind of medication brought great inconvenience to patients. fingolimod is a sphingosine-l-phosphate (s1pr) receptor modulator. after phosphorylation, it is bound to s1p receptor that is on the surface of lymphocyte, which will change lymphocyte migration, and promote cells into the lymphatic tissue, and prevent lymphocytes from leaving the lymphoid tissue and get into the graft. thereby, it will prevent these cells from infiltrating the central nervous system (cns), which achieves the effect of immunosuppression. according to the drug's introduction, drugmaker novartis said that this process of pharmacological effects is reversible. if medication is stopped, the level of lymphocytes in circulating system will return to normal. the above information is edited by the chemicalbook of kui ming.
chemical properties	white solid
usage	a derivative of isp-1 (myriocin), a fungal metabolite of the chinese herb iscaria sinclarii as well as a structural analogue of sphingosine. it is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibitin
usage	a derivative of isp-1 (myriocin), a fungal metabolite of the chinese herb iscaria sinclarii as well as a structural analogue of sphingosine. t is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. reported to be phosphorylated by sphingosine kinase to fty720-p, which has been shown to potently stimulate gtpgs binding activity in s1p-transfected cho cells (ec50 = 210 pm, 4.9 nm, 4.3 nm, and 1 nm for s1p1, s1p3, s1p4 and s1p5, respectively).
usage	oral medicine for the treatment of multiple sclerosis
usage	fty720 is a derivative of isp-1 (myriocin), a fungal metabolite of the chinese herb iscaria sinclarii as well as a structural analogue of sphingosine. fty720 is a novel immune modulator that prolong s allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. fty720 us reported to be phosphorylated by sphingosine kinase to fty720-p, which has been shown to potently stimulate gtpgs binding activity in s1p-transfected cho cells (ec50 = 210 pm, 4.9 nm, 4.3 nm, and 1 nm for s1p1, s1p3, s1p4 and s1p5, respectively).
usage	a cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.

fingolimod hydrochloride preparation products and raw materials

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.

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