83-67-0 discount Theobromine factory CAS NO.83-67-0

phosphosdiesterase inhibitor, weak adenosine receptor antagonist, diuretic and smooth muscle relaxant.

theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. it is an adenosine a₁ receptor antagonist theobromine (150 μg/ml) increases ampk phosphorylation and inhibits adipocyte differentiation, erk and jnk phosphorylation, and il-6 and tnf-α production in 3t3-l1 preadipocytes cultured in differentiation medium. it inhibits decreases in renal cortex sirt1 activity and increases in nadph oxidase-dependent reactive oxygen species (ros) production, as well as reduces kidney hypertrophy and albuminuria in a spontaneously hypertensive rat model of streptozotocin-induced diabetes when administered at a dose of 5 mg/kg per day. theobromine is toxic to dogs with an ld₅₀ value of 250 to 500 mg/kg.