918504-65-1 CAS NO.918504-65-1

Product Details

918504-65-1
N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide
C23H18ClF2N3O3S

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n-(3-(5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide basic information

product name:	n-(3-(5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
synonyms:	n-(3-(5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide;plx4032 (vemurafenib);r7204;n-(3-(5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonam;plx4032, r7204, rg7204, ro5185426;vemurafenib (plx4032, rg7204);n-[3-[[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide vemurafenib plx 4032;zelboraf (vemurafenib)
cas:	918504-65-1
mf:	c23h18clf2n3o3s
mw:	489.9221264
einecs:
product categories:	aromatics;heterocycles;intermediates & fine chemicals;pharmaceuticals;protein kinase inhibitors and activators;sulfur & selenium compounds;api;inhibitor;rg7204;antineoplastic
mol file:	918504-65-1.mol

n-(3-(5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide chemical properties

density

1.46

safety information

msds information

n-(3-(5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide usage and synthesis

chemical properties	off-white solid
usage	vemurafenib selective brafv600e kinase inhibitor; an antitumor agent. vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (erk) kinase and erk phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing brafv600e or other mutant braf proteins altered at codon 600.
usage	vemurafenib (plx4032, rg7204) is a novel and potent inhibitor of b-rafv600e with ic50 of 31 nm