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93106-60-6,Enrofloxacin CAS NO.93106-60-6

Min.Order Quantity:
1 Kilogram
Purity:
99%
Port:
China Main Port
Payment Terms:
L/C,T/T,MoneyGram

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Product Details

Keywords

  • Enrofloxacin
  • 93106-60-6
  • C19H22FN3O3

Quick Details

  • ProName: 93106-60-6,Enrofloxacin
  • CasNo: 93106-60-6
  • Molecular Formula: C19H22FN3O3
  • Appearance: NA
  • Application: Inorganic Chemicals
  • DeliveryTime: With about 7-10 days after receipt the...
  • PackAge: 1KG -200KG Drum with pallet
  • Port: China Main Port
  • ProductionCapacity: 1 Metric Ton/Week
  • Purity: 99%
  • Storage: NA
  • Transportation: by air
  • LimitNum: 1 Kilogram
  • Grade: Industrial Grade,Pharma Grade

Superiority

competitive price

high quality

fast delivery

custom-made

welcome to henan tianfu chemical co., ltd. website. our company engages in sodium tripolyphosphate (stpp) and sodium hexametabphosphate (shmp) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals imp&exp trading business. the company is located in zhengzhou high-tech development zone with import and export license. we passed iso 9001:2008 in 2009, and won "high-tech enterprise" by provincial government in 2013. our stpp and shmp has reached an annual output of 30000 tons and has successfully passed sgs, ciq audits on many occasions.


in 2011 we entered the fine chemical market of noble metal catalyst ,organic phosphine ligands and oled intermediates.with the joint efforts of our senior experts and professional technicians, tianfu has developed more than 500 compounds, which are widely used in the fields of production and life science. the objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal. improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. we are constantly striving to make henan tianfu a leading chemical supplier, and hope to create a better future with you.

Details


enrofloxacin basic information
veterinary fluoroquinolone antimicrobial agents reasonable compatibility incompatibility side effects precautions application
product name: enrofloxacin
synonyms: 1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-4-oxo-3-quinoli;3-quinolinecarboxylicacid,1,4-dihydro-1-cyclopropyl-7-(4-ethyl-1-piperazinyl);-6-fluoro-4-oxo-;bayvp2674;cfpq;enrofloxacin hcl;rofloxacin base;enrofloxacin baytril
cas: 93106-60-6
mf: c19h22fn3o3
mw: 359.4
einecs:
product categories: antibiotics for research and experimental use;biochemistry;quinolones (antibiotics for research and experimental use);intermediates & fine chemicals;pharmaceuticals;veterinaries;heterocycles;api;baytril;antibiosis
mol file: 93106-60-6.mol
enrofloxacin structure
enrofloxacin chemical properties
mp 225 °c
storage temp. -20°c freezer
merck 3592
cas database reference 93106-60-6(cas database reference)
safety information
hazard codes xi
risk statements 36/37/38
safety statements 26-36/37
wgk germany 3
rtecs vb1993650
hazardous substances data 93106-60-6(hazardous substances data)
msds information
provider language
1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid english
enrofloxacin usage and synthesis
veterinary fluoroquinolone antimicrobial agents enrofloxacin and sarafloxacin, danofloxacin, difloxacin, ofloxacin, norfloxacin, orbifloxacin are commonly used third-generation fluoroquinolone broad-spectrum antimicrobial agents in veterinary clinic at present , is ethyl compound of ciprofloxacin, also known as ethyl ciprofloxacin, ethyl ciprofloxacin, norfloxacin, is effective on gram-negative bacteria, gram-positive bacteria and mycoplasma, its antibacterial activity is significantly superior to norfloxacin, the effect on mycoplasma is stronger than tylosin and tiamulin fumarate. this product is oral, intramuscular and subcutaneous injection, and is easily absorbed, widely distributed in vivo, in addition to the central nervous system, the concentration of the drug in other organizations, almost all are higher than the blood concentration. de ethylation in vivo, mainly produced active metabolite ciprofloxacin, but different among the animals metabolism are larger, birds, dogs, rabbits and cattle body's metabolic rates are high, horses and pigs body's metabolic rates are lower. clinically enrofloxacin is used for the treatment of various mycoplasma disease, and respiratory system, digestive system and urogenital system infections, skin infections and sepsis caused by e. coli, salmonella, haemophilus, erysipelas bacillus, staphylococcus, streptococcus etc. especially suitable for mixing infections caused by a variety of bacteria.
spatial structure formulae diagram of enrofloxacin
spatial structure formulae diagram of enrofloxacin
the above information is edited by the chemicalbook of liu yujie.
reasonable compatibility 1. cooperated application of enrofloxacin with aminoglycoside (gentamicin), third-generation cephalosporins (cefotaxime, ceftriaxone) and penicillin, colistin, may have synergistic antibacterial effect on certain bacteria (especially pseudomonas aeruginosa or enterobacteriaceae), in addition to penicillin-type drugs, due to enhanced toxicity, when in combination, need to reduce the dose, and administered separately.
2. antibacterial activity of enrofloxacin combined with apramycin enhanced, showed a synergistic effect. the reason was that antibacterial mechanism of apramycin was to specifically hinder biosynthesis of bacterial protein, and thus achieved effect on inhibiting and killing bacteria, while enrofloxacin could specifically act on subunit a of bacterial dna gyrase, inhibiting its activity, affecting dna melting and sealing chain, both of combination had double blocking effect on bacterial replication and translation process.
3. at the same day were successively mixed to drink with colistin sulfate, can improve the efficacy of enrofloxacin on chicken bacterial disease. and compatibility with sd silver used for the topical treatment of otitis in dogs.
reference data: zheng hugong, cui yaoming editor. reasonable compatibility use of veterinary, zhengzhou: henan science and technology press, 2009.
incompatibility 1. enrofloxacin can inhibit metabolism of theophylline and caffeine, make the blood concentration increase, thereby causing toxic reactions.
2. combined with anticholinergic drugs (atropine, 654-2) and h2 receptor antagonists (cimetidine, famotidine), making the bioavailability of enrofloxacin reduce.
3. enrofloxacin has a role in inhibiting liver drug enzymes, in combination with drugs metabolized in the liver such as erythromycin, lincomycin, etc. making its clearance decrease, blood concentration increased.
4. antacids may reduce absorption of enrofloxacin in the gastrointestinal tract, not suitable for simultaneous use.
5. mixed with strongly acidic liquid and the strong alkaline liquid and precipitated.
6. enrofloxacin and metoclopramide occur chemical changes, easy to turn into muddy, should not be mixed injection.
side effects toxicity of enrofloxacin is less, safe for clinical use. therapeutic doses have non-teratogenic and mutagenic effect. can make young animals cartilage occur turbid, causing lameness and pain. digestive system reactions are vomiting, abdominal pain and bloating. skin reactions are erythema, pruritus, urticaria and photosensitivity reactions, etc.
precautions 1. enrofloxacin aqueous solution was met with light and easy to change color and decompose, should be kept in dark place.
2. drug-resistant strains of the product showed an increasing trend, not used at sub-therapeutic doses for long-term.
3. antacids can inhibit the absorption of this product, should be avoided drinking at the same time.
4. in clinical application, can appropriately adjust dosage based on disease, concentration range of drinking water in poultry, per liter of water, added 25 to 100 mg.
5. withdrawal period of chicken is 8 days. disabled in egg producing period of laying hen.
6. chicks are very sensitive to enrofloxacin injection, had many poisoning report, the dose should be strictly controlled.
application 1. antimicrobial, for bacteria and mycoplasma infection.
2. new veterinary antimicrobial drugs, broad-spectrum, high efficiency, has special effects on gram-positive and gram-negative bacteria and mycoplasma.
chemical properties pale yellow crystals
usage fluorinated quinolone antibacterial
enrofloxacin preparation products and raw materials

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