Welcome to LookChem.com Sign In|Join Free
  • or
HENAN SUNLAKE ENTERPRISE CORPORATION99.9% PURITY CAS.NO : 41294-56-8 C27H44O2 Alfacalcidol//file1.lookchem.com/cas/reactions/2021/07/14/2064794.png
qq

Communicate with Supplier:

Ms. summer
Ms. summer: What can I do for you?

99.9% PURITY CAS.NO : 41294-56-8 C27H44O2 Alfacalcidol CAS NO.41294-56-8

Min.Order Quantity:
10 Gram
Purity:
99.9%
Port:
Any Chinese main ports
Payment Terms:
L/C,T/T,MoneyGram,Other

Add to Inquiry Cart

Product Details

Keywords

  • BUY 41294-56-8 FROM OWN LAB
  • BEST QUALITY 41294-56-8 IN CHINA MARKET
  • 41294-56-8 SUPPLIERS

Quick Details

  • ProName: 99.9% PURITY CAS.NO : 41294-56-8 C27H4...
  • CasNo: 41294-56-8
  • Molecular Formula: C27H44O2
  • Appearance: white powder
  • Application: 41294-56-8
  • DeliveryTime: Within 7 working days since received y...
  • PackAge: 1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25...
  • Port: Any Chinese main ports
  • ProductionCapacity: 20 Kilogram/Month
  • Purity: 99.9%
  • Storage: Room temperature with sealed well
  • Transportation: BY SEA /BY COURIER /BY AIR
  • LimitNum: 10 Gram
  • Grade: Industrial Grade,Pharma Grade,Electron...
  • Certification: ISO /9001

Superiority

1. iso 9001 approved, gmp producing standard,proffesional qa system, our quality is guaranteed.

2. facotory direct sale, most comptive price ensured;

3. audited supplier on lookchem, no trick, no scam!

4. enough stock can make sure safe delivery.

5. complete before and after sale service, welcome your questions and glad to help.

Details

product information :

alfacalcidol basic information
physical and chemical properties pharmacological effects pharmacodynamics indications instructions adverse reactions precautions drug interactions uses
product name: alfacalcidol
synonyms: vitamin d3, 1alpha-hydroxy-;hydroxyvitamin d3;alfacalcidol;alphacalcidol;1-hydroxycholecalciferol;1alpha-oh-d3;1-alpha-hydroxycholecalciferol;1-alpha-hydroxyvitamin d
cas: 41294-56-8
mf: c27h44o2
mw: 400.64
einecs: 255-297-1
product categories: vitamin d3 analogs;api;intermediates & fine chemicals;pharmaceuticals;miscellaneous compounds;inhibitors
mol file: 41294-56-8.mol
alfacalcidol structure
alfacalcidol chemical properties
mp 134-136°c
storage temp. −20°c
cas database reference 41294-56-8(cas database reference)
epa substance registry system 9,10-secocholesta- 5,7,10(19)-triene-1,3-diol, (1.alpha.,3.beta.,5z,7e)-(41294-56-8)
safety information
hazard codes t+,xi
risk statements 26/27/28-36/37/38
safety statements 28-36/37-45-36-26
ridadr un 2811 6.1/pg 1
wgk germany 3
rtecs vs2851000
f 8-10
hazardclass 6.1(a)
packinggroup i
hs code 29361000
msds information
provider language
alfacalcidol english
sigmaaldrich english
alfacalcidol usage and synthesis
physical and chemical properties white crystal or crystalline powder, insoluble in water and hexane, soluble in methanol, ethanol, chloroform, methylene chloride, acetone or ether. perishable in case of air and light .
pharmacological effects alfacalcidol is quickly converted by the liver into 1,25-dihydroxyvitamin d3, regulates calcium balance in the body, because of the enhancing of 1,25-dihydroxyvitamin d3 levels in vivo circulating , thereby increases the calcium and phosphorus intestinal absorption, promotes bone mineralization, decreases parathyroid hormone levels in plasma and reduces calcium resorption, relieves bone, muscle pain and improves osteoporosis and menopause, aging and steroid-induced intestinal related calcium malabsorption.
alfacalcidol increases the intestinal and renal tubular reabsorption of calcium and inhibit parathyroid hyperplasia, reduces parathyroid hormone synthesis and release, inhibits bone resorption. promotes collagen and bone matrix protein synthesis.regulates calcium metabolism of muscles , promotes muscle cells differentiation, enhances muscle strength, increases neuromuscular coordination, tends to reduce falls. suitable for the treatment of rickets and osteomalacia, renal osteodystrophy, osteoporosis and hypoparathyroidism. youth are limited to young people with idiopathic osteoporosis and glucocorticoid-induced osteoporosis too.
the above information is edited by the chemicalbook of tian ye.
pharmacodynamics this product after oral administration, is rapidly absorbed into the bloodstream from the gut, 25-hydroxy enzyme of the liver microsomal make 25-hydroxy of side chain compound to generate 1α, 25- (oh) 2d3, distributed in the intestine and bone and other target tissues, upon binding to the receptor, it can promote intestinal absorption of calcium, causing a series of physiological activities, such as bone salt dissolving and bone formation . rats removed of the kidney and rats deficient in vitamin d, are given this product experiments, which shows that the level of promoting intestinal absorption of calcium, elevates serum calcium.due to renal completely removed in rats removed of the kidney , the majority of bone resorption and bone-like cavity layer, low-calcified layer next layer increases, give this product 30d to experiment, the bone freshmen is observed. therefore alfacalcidol promotes bone formation. elderly patients with osteoporosis given this product ,iliac bone biopsy is performed by electronic and optical microscope to find that active osteoblasts, osteocytes, bone calcification small chamber increases, improves bone tissue.
indications symptoms alfacalcidol can be used to improve chronic renal insufficiency, hypoparathyroidism, vitamin d-dependent rickets, a softening of bone disease caused by vitamin d metabolism, such as hypocalcemia, hand, foot cramps, pain , bone disease and osteoporosis embolism.
instructions for osteoporosis, oral: initial amount of 0.5μg / d, maintenance dose of 0.25 ~ 0.50μg, qd.
dialysis patients with chronic hypocalcemia, 0.5 ~ 3.0μg / d, divided 2 to 3 times daily.
hypoparathyroidism, 0.25 ~ 3.00μg / d, divided 2 to 3 times daily.
renal bone atrophy, the next day 0.25 ~ 3.00μg, divided 2 to 3 times daily.
vitamin d-dependent rickets, 1μg / d, divided 2 to 3 times daily.
familial hypophosphatemia, 2μg / d, divided 2 to 3 times daily.
adverse reactions small amount alone is usually no more adverse reactions, long-term large doses of medication or in combination with calcium can cause hypercalcemia and hypercalciuria.patients in long-term high doses and patients with renal impairment may be nausea, loss of appetite, dizziness, skin itching, rash, constipation, anorexia, vomiting, abdominal pain, high calcium signs ,it can be restored to normal after treatment. vitamin d and its analogues allergies, hypercalcemia, vitamin d poisoning signs patients are banned. early medication serum calcium levels should be determined weekly, when a stable dose, they are measured every 2 to 4 weeks, especially renal dysfunction serum calcium levels should be measured regularly. when hypercalcemia occurs, it shall be discontinued and deal with hypercalcemia. after serum calcium returns to normal , the dose is dministered half of the last dose. alfacalcidol combination with calcium can cause elevated serum calcium, when it combined with thiazide diuretics can cause the danger of hypercalcemia . when treated with digitalis drugs, care should be taken to develop the amount of this drug.the amount of alfacalcidol should be increased when combined with barbiturates, anticonvulsants .
precautions if hypercalcemia occurs,it should be stopped taking until serum calcium returns to normal (about a week), and then press the last half dose administration. patients have vitamin d symptoms or known allergy to vitamin d and its analogues is unfit for use. patients should avoid taking vitamin d drugs at the same time, so as not to cause vitamin d intoxication.
drug interactions using alfacalcidol and magnesium formulation (magnesium oxide, magnesium carbonate, etc.) sometimes causes hypermagnesemia.
using alfacalcidol and cardiac preparations may cause cardiac arrhythmia.
using alfacalcidol and vitamin d and its derivatives (calcitriol) , it is possible to cause hypercalcemia.
using alfacalcidol and calcium , thiazide diuretics, digitalis drugs , can cause hypercalcemia.
and barbiturates, anti-seizure drugs may reduce the efficacy of the drug.
gastrointestinal absorption inhibitors can reduce the absorption of the drug.
combination with large doseas of phosphorus compounds, can induce hyperphosphatemia.
when alfacalcidol and calcium preparations (calcium lactate, calcium carbonate, etc.) are used together, there may be hypercalcemia.
uses for the treatment of osteoporosis, vitamin d-dependent rickets and osteomalacia
chemical properties white solid
usage a synthetic analog of calcitiol (the hormonal form of vitamin d3), which shows identical potency with respect to stimulation of intestinal calcium absorption and bone mineral mobilization. vitamin d source

company information :

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Related Products

Related Keywords

Inquiry Cart 0