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Hubei Langyou International Trading Co., Ltd99%min Bimatoprost Manufacturer For Glaucoma Treatment//file1.lookchem.com/cas/reactions/2021/05/27/9365461.png
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99%min Bimatoprost Manufacturer For Glaucoma Treatment CAS NO.155206-00-1

Min.Order Quantity:
10 Gram
Purity:
99%min
Port:
ShangHai
Payment Terms:
T/T,MoneyGram

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Product Details

Keywords

  • Pharmaceutical Intermediate
  • For Glaucoma Treatment
  • API Manufacturer

Quick Details

  • ProName: 99%min Bimatoprost Manufacturer For Gl...
  • CasNo: 155206-00-1
  • Molecular Formula: C25H37NO4
  • Appearance: White Powder
  • Application: For Pharmaceutical Intermediates
  • DeliveryTime: 2-4 days after confirming your payment...
  • PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
  • Port: ShangHai
  • ProductionCapacity: 1000 Metric Ton/Month
  • Purity: 99%min
  • Storage: Dry and cool place
  • Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
  • LimitNum: 10 Gram

Superiority

advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.


1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.


2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.


3. discreet package safelyand professionally disguised package guaranteed. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.


4. warm after-sale service any of your question would be solved for the first as soon as possible.

Details

bimatoprost basic information
glaucoma drug side effects glaucoma commonly used drugs bimatoprost - timolol maleate compound eye drops
product name: bimatoprost
synonyms: n-ethyl-9alpha,11alpha,15s-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5z, 13e-dien-1-amide;lumigan;bimatoprost;bimatoprost(tm);17-phenyl trinor prostaglandin f2alpha ethyl amide;bimatoprost(lumigan);17-phenyl-tri-norprostaglandin f2α-ethyl amide;(z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(e,3s)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-n-ethylhept-5-enamide
cas: 155206-00-1
mf: c25h37no4
mw: 415.57
einecs: 2017-001-1
product categories: prostaglandins;prostaglandin;chiral reagents;intermediates & fine chemicals;pharmaceuticals;arachidonic acid cascade;lipids in cell signaling;lumigan;inhibitors;benzotriazoles ,others ,benzoxazines;pharmaceutical intermediate
mol file: 155206-00-1.mol
bimatoprost structure
bimatoprost chemical properties
melting point 66-68°c
storage temp. −20°c
form solid
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cas database reference 155206-00-1(cas database reference)
safety information
wgk germany 3
bimatoprost usage and synthesis
glaucoma drug bimatoprost is a synthetic amide f2α derivative ,it can selectively simulate the effect forefront amines produced by the body, which make aqueous humor production rate increase aqueous outflow resistance is reduced, by increasing the amount of aqueous outflow of the uveoscleral and trabecular netcom channel to reduce intraocular pressure (iop),it is considered to be the most effective hypotensive drug of topical ocular anti-glaucoma drugs,it is suitable for the treatment of open-angle glaucoma (poag) or invalid elevated intraocular other ocular hypotensive medications compression syndrome (oht) patients.
side effects 1. to deepen the color of the iris, blepharitis, eye irritation and pain; black eyelashes thicker growth; conjunctival hyperemia, temporarily punctate corneal epithelial erosion, eyelid edema and erythema; rash.
2. rare respiratory disorders, asthma exacerbations, iritis, uveitis, eyelid skin darkening.
3. very rare chest pain, pharyngitis.
4. eye itching, allergic conjunctivitis, cataract, conjunctival edema, secretions, photophobia, superficial punctate keratitis, headache, high blood pressure.
glaucoma commonly used drugs 1. prostaglandin derivatives such as latanoprost (xalatan), bimatoprost (trade name lumigan) and travoprost (travatan) can increase outflow of aqueous humor uveoscleral . bimatoprost also increases trabecular outflow.
2. topical β-adrenergic such as timolol, levobunolol (betagan), and betaxolol can decrease receptor antagonist of aqueous humor production of ciliary body .
3. alpha2-adrenergic agonists such as brimonidine (alphagan) with dual working mechanism, can reduce aqueous humor production and increase trabecular outflow.
4. one case of the selective reduction similar to epinephrine and dipivefrin (propine) increase outflow of aqueous humor through trabecular meshwork and possibly through uveoscleral outflow pathway, probably by a β2-agonist action.
5. miotic agents (parasympathomimetics), if ciliary muscle contraction roca works, it can tighten the trabecular and allow increaseing outflow of aqueous humor. ecothiopate is used for chronic glaucoma.
6. dorzolamide (trusopt), brinzolamide (azopt), by inhibiting carbonic anhydrase acetazolamide of ciliary body, reduce aqueous humor secretion of carbonic anhydrase inhibitors.
7. physostigmine is also used to treat glaucoma and delayed gastric emptying.
the above information is edited by the chemicalbook of tian ye.
bimatoprost - timolol maleate compound eye drops in july 2006 , bimatoprost-timolol maleate compound eye drops developed by the united states company obtained approval from the european drug regulatory authority for reducing intraocular pressure or ocular hypertension of open-anglepatients glaucoma patients who do not respond adequately to the β-blockers or prostaglandin like treatment .
the compound eye drops containing 0.03% bimatoprost and 0.5% timolol maleate, once a day administration is able to provide clinically effective pressure control, the effect is better than single bima latanoprost or timolol maleate. clinical trials prove that the drug has an excellent tolerability, including the incidence of ocular hyperemia40% lower compared to single bimatoprost .
chemical properties crystalline solid
uses antiglaucoma. synthetic prostamide; structurally related to prostaglandin f2a.
uses antiglaucoma. synthetic prostamide; structurally related to prostaglandin f2α.
uses bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. it reduces intraocular pressure (iop) by increasing the outflow of aqueous fluid from the eyes. it ha
uses bimatoprost is an antiglaucoma agent. bimatoprost is an synthetic prostamide; structurally related to prostaglandin f2α.
uses 17-phenyl trinor prostaglandin f2α ethyl amide (17-phenyl trinor pgf2α ethyl amide) is an f-series pg analog which has been approved for use as an ocular hypotensive drug. investigations in our lab have shown that 17-phenyl trinor pgf2α ethyl amide is converted by an amidase enzymatic activity in the bovine and human cornea to yield the corresponding free acid, with a conversion rate of about 40 μg/g corneal tissue/24 hours. the free acid, 17-phenyl trinor pgf2α, is a potent fp receptor agonist. in human and animal models of glaucoma, fp receptor agonist activity corresponds very closely with intraocular hypotensive activity.[cayman chemical]

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