Antidepressant Drug Ingredients , CAS 99300-78-4 Venlafaxine HCL API Powder CAS NO.99300-78-4

Min.Order Quantity:: 10 Gram

Purity:: 99%

Port:: Wuhan

Payment Terms:: T/T,

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Keywords

99300-78-4
Venlafaxine Hydrochloride
Venlafaxine hcl

Quick Details

ProName: Antidepressant Drug Ingredients , CAS ...
CasNo: 99300-78-4
Molecular Formula: C17H28ClNO2
Appearance: White crystalline powder
Application: Pharmaceutical Raw Materials; Pharmace...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: Wuhan
ProductionCapacity: 10 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

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Details

antidepressant drug ingredients , cas 99300-78-4 venlafaxine hcl api powder

quick detail

venlafaxine hydrochloride
cas no.:	99300-78-4
synonyms:	venlafaxine hydrochloride; venlafaxine hydrochloride;
formula:	c17h28clno2
exact mass:	313.18100
molecular weight:	313.86300
psa:	32.70000
logp:	3.83760
appearance & physical state:	white crystalline powder
density:	1.394 g/cm3
melting point:	207-209ºc
boiling point:	397.6ºc at 760 mmhg
flash point:	194.2ºc

venlafaxine description

venlafaxine is a widely used serotonin- and norepinephrine-reuptake inhibitor-type antidepressant that causes serious adverse effects in at least 5% of cases. serious withdrawal symptoms may occur within hours of cessation or reduction of the usual dosage and may affect motor and coordination skills to such a degree that patients should be explicitly urged either to adhere to a strict medication routine or not to drive a car. recent clinical evidence about withdrawal symptoms is presented that may indicate incidents in noradrenergic activity irrespective of dosage.

venlafaxine usage

1	major depressive disorder
2	generalized anxiety disorder
3	social anxiety disorder (social phobia)
4	panic disorder
5	patients with hepatic impairment
6	patients with renal impairment
7	maintenance treatment

dosage and administration

1 major depressive disorder	for most patients, the recommended starting dose for effexor xr is 75 mg per day, administered in a single dose. for some patients, it may be desirable to start at 37.5 mg per day for 4 to 7 days to allow new patients to adjust to the medication before increasing to 75 mg per day. patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of 225 mg per day. dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of venlafaxine and its major metabolites are achieved in most patients by day 4
2 generalized anxiety disorder	for most patients, the recommended starting dose for effexor xr is 75 mg per day, administered in a single dose. for some patients, it may be desirable to start at 37.5 mg per day for 4 to 7 days to allow new patients to adjust to the medication before increasing to 75 mg per day. patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of 225 mg per day. dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of venlafaxine and its major metabolites are achieved in most patients by day 4
3 social anxiety disorder (social phobia)	the recommended dose is 75 mg per day, administered in a single dose. there was no evidence that higher doses confer any additional benefit.
4 panic disorder	the recommended starting dose is 37.5 mg per day of effexor xr for 7 days. patients not responding to 75 mg per day may benefit from dose increases to a maximum of approximately 225 mg per day. dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 7 days.
5 patients with hepatic impairment	the total daily dose should be reduced by 50% in patients with mild (child-pugh=5-6) to moderate (child-pugh=7-9) hepatic impairment. in patients with severe hepatic impairment (child-pugh=10-15) or hepatic cirrhosis, it may be necessary to reduce the dose by 50% or more
6 patients with renal impairment	the total daily dose should be reduced by 25% to 50% in patients with mild (clcr= 60-89 ml/min) or moderate (clcr= 30-59 ml/min) renal impairment. in patients undergoing hemodialysis or with severe renal impairment (clcr < 30 ml/min), the total daily dose should be reduced by 50% or more. because there was much individual variability in clearance between patients with renal impairment, individualization of dosage may be desirable in some patients
7 maintenance treatment	there is no body of evidence available from controlled studies to indicate how long patients with mdd, gad, sad, or pd should be treated with effexor xr. it is generally agreed that acute episodes of mdd require several months or longer of sustained pharmacological therapy beyond response to the acute episode. effexor xr/effexor have demonstrated continuation of response in clinical studies up to 52 weeks, at the same dose at which patients responded during the initial treatment

precautions use cautiously in

• cardiovascular disease; hypertension; heart failure, recent myocardial infarction, and other conditions in which increasedheart rate poses a danger; hepatic or renal impairment; glaucoma; hyperthyroidism; hyponatremia; syndrome ofinappropriate antidiuretic hormone secretion (siadh)
• history of seizures, neurologic impairment, or drug abuse
• pregnant or breastfeeding patients
• children younger than age 18.

advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.

1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.

2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.

3. discreet package safelyand professionally disguised package guaranteed. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.

4. warm after-sale service any of your question would be solved for the first as soon as possible.