Artemether China manufacture 98.0%min GMP CAS NO.71963-77-4

appearance

white crystal or crystalline powder,odorless,taste slightly bitter

solubility

very soluble in chloroform or acetone ; freely soluble in ethanol or ethyl acetate, practically insoluble in water

conforms

melting point

86～90℃

specific optical rotation

+168°～+173°

identification

color reaction

a pale yellow color is produced

color reaction

a peach blow color is produced

hplc

the retention time of main peak of the test and standard are concordant

ir

infrared absorption spectrum of test and standard (or infrared reference spectra no. 519)are concordant

tests

chlorides

not more pronounced (0.01%)

related substances

(hplc)

any single impurity≤0.5%

any impurity between 0.25% and 0.5%≤1

total impurities ≤1%

residual solvent

(gc)

methanol ≤0.3%

dichloromethane ≤0.06%

loss on drying

≤ 0.5%

residual on ignition

≤ 0.1%

assay (on dried basis)

98.0% ～102.0％(hplc)