azd-2281 lynparza (olaparib) cas 763113-22-0 to treat advanced ovarian cancer

description

product name:

lynparza

cas:	763113-22-0
mf:	c21h26o3
mw:	434.46
einecs:	259-474-4
solubility (25°c)	dmso 86 mg/ml warming (197.94 mm) water 0.002 mg/ml (0.0 mm) ethanol <1 mg/ml

usage:olaparib is a potent poly(adp-ribose) polymerase (parp) inhibitor. olaparib has been shown to induce significant killing of atm-deficient lymphoid tumor cells in vitro and in vivo. recent studies show that olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.

lynparza is a poly adp-ribose polymerase (parp) inhibitor that blocks enzymes involved in repairing damaged dna. it is intended for women with heavily pretreated ovarian cancer that is associated with defective brca genes.

specification

item	specifications	results
description	white powder	conforms
identification	shall comply	all comply
loss on drying	≤0.5%	0.1%
sulphated ash	≤0.1%	0.04%
heavy metals	≤0.002%	<0.002%
palladium	≤0.001%	not examined
particle size tapped density loose density	100%<60um	conforms 0.386g/ml 0.205g/ml
related substances individual impuriti total impurities	≤0.3% ≤1.0%	0.23% 0.36%
assay (on dried basis)	98%to102.0%	99.8%
conclusion	the results conforms with ep6.0 standards

application:

olapanil is a novel poly-adp ribose polymerase (parp) inhibitor, including parp1, parp2, and parp3. parp mediates a mechanism of dna repair and plays an important role in dna damage repair and cell apoptosis. therefore, the mechanism of dna damage repair by targeting to cells is mediated by parp1 and parca2 mutant cancer cells of the critical loopholes in the role, can be used for breast cancer susceptibility gene (brca) mutations, platinum-sensitive drug-resistant patients with recurrent severe ovarian cancer maintenance therapy.

olaparib is a kind of novel poly adp-ribose polymerase (parp) inhibitors, including parp1, parp2, and parp3. parp mediates a dna-repair mechanism which plays a important role in dna damage repair and apoptosis, so olaparib specifically targets on the dna repair mechanism of the targeting cell dna repair and take effects by attacking the critical vulnerabilities of cancer cells carrying mutations in brca1 and brca2. owing to this mechanism, it can be used for the maintenance therapy of patients of severe recurrent ovarian cancer who has breast cancer susceptibility gene (brca) mutation as well as being sensitive to platinum drug.

scientists from harvard medical school dana - farber cancer institute have found that the target site of olaparib is the polymerase q (polq, also known polθ). those scientists found that a large number of patients of ovarian cancer has the genetic deficiency in the homologous recombination (homologous recombination, hr) repair pathway and dramatic up-regulated expression of polq greatly. since hr is an important repair pathway for repairing broken dna, they speculated that the major function of polq is to compensate for the lack of hr and participate in dna repair.

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advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.

1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.

2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.

3. discreet package safelyand professionally disguised package guaranteed. for your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate.

4. warm after-sale service any of your question would be solved for the first as soon as possible.

azd-2281 lynparza (olaparib) cas 763113-22-0 to treat advanced ovarian cancer