Afine Chemicals Limited
Country: China (Mainland)
Year Established: 2005
Business License:
Business type: Lab/Research institutions
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Buy High quality of cost Bicalutamide 90357-06-5 CAS NO.90357-06-5

Min.Order Quantity:: 1 Kilogram

Purity:: 99%min

Port:: Shanghai or Hangzhou or Beijing etc

Payment Terms:: L/C,D/A,D/P,T/T,

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Buy Bicalutamide
High quality of Bicalutamide
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Quick Details

ProName: Buy High quality of cost Bicalutamide ...
CasNo: 90357-06-5
Molecular Formula: C18H14F4N2O4S
Appearance: white to off white powder
Application: Pharmaceutical active ingredients Pha...
DeliveryTime: Usually One week
PackAge: According to regular packing:bottle,Fo...
Port: Shanghai or Hangzhou or Beijing etc
ProductionCapacity: 1-100 Kilogram/Month
Purity: 99%min
Storage: Shall be stored it in a dry and cool a...
Transportation: ocean shipping or air transportation
LimitNum: 1 Kilogram
Related Substances: Effective ingredients >99%
Residue on Ignition: 0.1
Heavy Metal: 0
Valid Period: 3 year
COA&Document: Please send us inquiry

Superiority

buy high quality of cost bicalutamide 90357-06-5

1. new molecules r&d

2. own test center hplc nmr gc lc-ms

3. api and intermediates from china reputed manufacturers

4. documents support coa moa msds dmf open part

our advantages

1. government awarded company. top 100 enterprises in hangzhou

2. quality warrant. if any quality failure. we 100% return the payment or replacement

3.more than 14 years experiences in pharmaceutical and chemical international trading

4.fast response on customers request and fast shipment

bicalutamide basic information

bicalutamide solubility determination of the content of bicalutamide tablets by high performance liquid chromatography (hplc) bicalutamide tablets adverse reaction chemical properties uses producing method

product name:	bicalutamide
synonyms:	(+-)--2-hydroxy-2-methyl;propanamide,n-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl);ici-176334;casodex;bicalutamide;n-[(4-cyano-3-trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide;n-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionanilide;bicalutamide (subject to patent free)
cas:	90357-06-5
mf:	c18h14f4n2o4s
mw:	430.3733728
einecs:
product categories:	api;modrastane;active pharmaceutical ingredients;antiandrogen;antineoplastic (hormonal);anti-neoplastic;-;aromatics;intermediates & fine chemicals;pharmaceuticals;sulfur & selenium compounds;api's
mol file:	90357-06-5.mol

bicalutamide usage and synthesis

bicalutamide solubility soluble in dimethyl formamide; dissolved in tetrahydrofuran; slightly soluble in ethyl acetate and methanol; insoluble in water.

determination of the content of bicalutamide tablets by high performance liquid chromatography (hplc) using shimadzu clc-ods (150mm´6.0mm, 5μ) column. 0.1% potassium dihydrogen phosphate solution-acetonitrile (50:50) as the mobile phase, detecting at 272nm wavelength. result: bicalutamide had a good linear relationship (r=0.9995) when the concentration in the range of 0.05mg*ml-1~0.20mg*ml-1. the average recovery was 99.5%, and rsd=0.9% (n=9 ) conclusion: the method is simple, good accuracy and high precision.

bicalutamide tablets bicalutamide tablet is a non-steroidal androgen antagonist, which competes androgen receptor with the androgen, blocks cellular uptake of androgen, and inhibits the binding of androgens to the target organ. it binds with the androgen receptor that forms receptor complex, which enters the nucleus and combined with the nucleoprotein, consequently inhibiting tumor cell growth. it can be as a first-line drug for palliative treatment of advanced prostate cancer.

dosage and administration:

adult: adult males including the elderly: one (50mg), once a day. the treatment should be started simultaneously with lhrh analogue therapy or surgical orchiectomy.

children: this product is contraindicated in children.

renal impairment: the patients with renal impairment don’t need dose adjustment.

hepatic impairment: the patients with mild liver damage don’t need dose adjustment, while the patients with severe liver damage may occur drug accumulation (see precautions).

precautions:

this product is widely metabolized in the liver. data show that patients with severe liver damage may slow down drug clearance, which may lead to accumulation. so the patients with moderate and severe liver injury should use it with caution.

the patients may appear liver changes by using it, so it should be considered regular liver function tests. the main changes generally appear within the first 6 months of treatment using this product.

severe changes in liver function are rarely visible in the treatment of the product (see adverse reactions). if there is a serious change in treatment using this product, it should be discontinued.

this product is shown to inhibit the activity of cytochrome p450 (cyp3a4). when combined with drugs metabolised mainly by cyp3a4, the patients should be caution (see contraindications and drug interactions).

pregnancy and lactation: this product is contraindicated in women, especially for pregnant women or nursing mothers.

effect on driving and operating machinery ability: this product does not affect the ability of patients of driving and operating the machine.

the above information is edited by the chemicalbook of kui ming.