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levothyroxine sodium basic information |
product name: | levothyroxine sodium |
synonyms: | levothyroxine sodium;sodium 4-o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosine;(s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic acid odium;(s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic acid sodium salt sodium (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate;sodium (s)-2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate;l-tyrosine,o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt (1:1);levothyroxine sodium ,t4;l-thyroxine sodium salt pentahydrate |
cas: | 55-03-8 |
mf: | c15h20i4nnao9 |
mw: | 888.93 |
einecs: | 200-221-4 |
product categories: | medicine intermediate;amino acids;biochemistry;biological-modified amino acids;amino acids & derivatives;aromatics;intermediates & fine chemicals;pharmaceuticals;steroid and hormone |
mol file: | 55-03-8.mol |
levothyroxine sodium chemical properties |
melting point | 207-210 (dec.)(lit.) |
alpha | d20 -4.4° (c = 3 in 70% ethanol) |
density | d420 2.381 |
storage temp. | 2-8°c |
solubility | cell culture medium: 0.1 mg/ml |
form | powder |
epa substance registry system | l-tyrosine, o-(4-hydroxy-3,5-diiodophenyl)- 3,5-diiodo-, monosodium salt(55-03-8) |
safety information |
safety statements | 22-24/25 |
ridadr | 2811 |
wgk germany | 3 |
rtecs | yp2833760 |
f | 3-8-10 |
hazardclass | 6.1(a) |
packinggroup | ii |
msds information |
provider | language |
---|---|
acros | english |
sigmaaldrich | english |
levothyroxine sodium usage and synthesis |
chemical properties | white solid |
uses | one of the thyroid hormones involved in the maintenance of metabolic homeostasis. synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. synthesis and secretion are regulated by the pituitary hormone (tsh). deiodinated in peripheral tissues to the active metabolite, liothyronine. the d-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia. |
definition | chebi: the sodium salt of l-thyoxine. it is used as replacement therapy in the treatment of hypothyroidism. |
levothyroxine sodium preparation products and raw materials |
raw materials | acetic acid glacial-->l-thyroxine-->sodium levothyroxine |