C40H53N7O5S2 Cobicistat 1004316-88-4 CAS NO.1004316-88-4

Min.Order Quantity:: 1 Metric Ton

Purity:: 99.5%

Port:: Any port of China

Payment Terms:: L/C,T/T,

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Product Details

Keywords

Cobicistat
1004316-88-4
C40H53N7O5S2

Quick Details

ProName: C40H53N7O5S2 Cobicistat 1004316-...
CasNo: 1004316-88-4
Molecular Formula: C40H53N7O5S2
Appearance: Powder
Application: 1004316-88-4
DeliveryTime: by air
PackAge: Aluminium Foil Bag and Paper Drum
Port: Any port of China
ProductionCapacity: 100 Metric Ton/Day
Purity: 99.5%
Storage: 1MT
Transportation: By Sea/Air/DHL
LimitNum: 1 Metric Ton
Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

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1.noble metal catalysts (pt.pd...)

2.organic phosphine ligands (tert-butyl-phosphine.cyclohexyl-phosphine...)

3.oled intermediates (fluorene,carbazole,boric acid...)

4.customs synthesis

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Details

cobicistat basic information

description in vitro

product name:	cobicistat
synonyms:	cobicistat;cobicistat (gs-9350);thiazol-5-ylmethyl (2r,5r)-5-((s)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-4-morpholinobutanamido)-1,6-diphenylhexan-2-ylcarbamate;gs 9350;gs9350;gs-9350;cobicistat d8;(3r,6r,9s)-12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid 5-thiazolylmethyl ester
cas:	1004316-88-4
mf:	c40h53n7o5s2
mw:	776.02272
einecs:
product categories:	inhibitor;inhibitors
mol file:	1004316-88-4.mol

cobicistat chemical properties

density

1.228±0.06 g/cm3 (20 ºc 760 torr)

safety information

msds information

cobicistat usage and synthesis

description	cobicistat (gs-9350) is a potent and selective inhibitor of cyp3a with ic50 of 30-285 nm.
in vitro	cobicistat (gs-9350) is a potent, and selective inhibitor of human cytochrome p450 3a (cyp3a) enzymes as a pharmacoenhancer. gs-9350 inhibits cyp3a with ic50 spectrum from 30 nm to 285 nm. in contrast to ritonavir, gs-9350 is devoid of anti-hiv activity, with ic50 of > 30μm against hiv-1 protease and ec50 of > 30μm in mt-2 hiv infection assay, and is thus more suitable for use in boosting anti-hiv drugs without risking selection of potential drug-resistant hiv variants. gs-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir.
uses	cobicistat is a hiv protease inhibitor and have been coadministered with low-dose ritonavir (r535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
uses	isotope labelled analogue of cobicistat (c633150), a hiv protease inhibitor and have been coadministered with low-dose ritonavir (r535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
uses	antiretroviral;labeled cobicistat, intended for use as an internal standard for the quantification of cobicistat by gc- or lc-mass spectrometry.