USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
USD $1.00-1.00 / Kilogram
triethyl orthoformate basic information |
product name: | triethyl orthoformate |
synonyms: | orthoformic acid triethyl ester;teof;triethyl-o-formate;triethyl orthoformate;triethoxymethane;1-(diethoxymethoxy)ethane;1,1',1'-(methylidynetris(oxy))tris(ethane);1,1’,1’-(methylidynetris(oxy))tris(ethane) |
cas: | 122-51-0 |
mf: | c7h16o3 |
mw: | 148.2 |
einecs: | 204-550-4 |
product categories: | orthoesters;amino acids;nutritional supplements;acetals/ketals/ortho esters;building blocks;chemical synthesis;organic building blocks;oxygen compounds;acs and reagent grade solvents;amber glass bottles;carbon steel cans with npt threads;reagent;reagent grade solvents;semi-bulk solvents;solvent bottles;solvent by application;solvent packaging options;solvents;anhydrous solvents;sure/seal bottles;organic synthesis;intermediates |
mol file: | 122-51-0.mol |
triethyl orthoformate chemical properties |
mp | −76 °c(lit.) |
bp | 146 °c(lit.) |
density | 0.891 g/ml at 25 °c(lit.) |
vapor density | 5.11 (vs air) |
vapor pressure | 2.9 mm hg ( 20 °c) |
refractive index |
n |
fp | 86 °f |
storage temp. | flammables area |
water solubility | 1.35 g/l |
sensitive | moisture sensitive |
merck | 14,6884 |
brn | 605384 |
cas database reference | 122-51-0(cas database reference) |
nist chemistry reference | ethyl orthoformate(122-51-0) |
safety information |
hazard codes | xi |
risk statements | 10-36-36/38 |
safety statements | 16-26-37/39-36-45-36/39 |
ridadr | un 2524 3/pg 3 |
wgk germany | 1 |
rtecs | rm6475000 |
f | 21 |
hazardclass | 3 |
packinggroup | iii |
hs code | 29159080 |
msds information |
provider | language |
---|---|
ethyl orthoformate | english |
acros | english |
sigmaaldrich | english |
alfa | english |
triethyl orthoformate usage and synthesis |
chemical properties | clear colourless liquid |
usage | labelled prednisolone 21-sulfate (p703755). prednisolone 21-sulfate is a metabolite of prednisolone (p703740). |
general description | a clear, colorless liquid with a pungent odor. less dense than water. flash point 86°f. vapors heavier than air. may irritate skin and eyes. used to make other chemicals. |
air & water reactions | highly flammable. slightly soluble in water. |
reactivity profile | triethyl orthoformate is an ester. esters react with acids to liberate heat along with alcohols and acids. strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. heat is also generated by the interaction of esters with caustic solutions. flammable hydrogen is generated by mixing esters with alkali metals and hydrides. |
health hazard | may cause toxic effects if inhaled or absorbed through skin. inhalation or contact with material may irritate or burn skin and eyes. fire will produce irritating, corrosive and/or toxic gases. vapors may cause dizziness or suffocation. runoff from fire control or dilution water may cause pollution. |
fire hazard | highly flammable: will be easily ignited by heat, sparks or flames. vapors may form explosive mixtures with air. vapors may travel to source of ignition and flash back. most vapors are heavier than air. they will spread along ground and collect in low or confined areas (sewers, basements, tanks). vapor explosion hazard indoors, outdoors or in sewers. runoff to sewer may create fire or explosion hazard. containers may explode when heated. many liquids are lighter than water. |
triethyl orthoformate preparation products and raw materials |
triethyl orthoformate, aka triethoxymethane, 1,1 ', 1 "(methylene three (oxo) three ethane, stimulating smell of liquid, melting point and boiling point is not high, miscible with ethanol, ether, slightly soluble in water, mainly used for used as a raw material for preparing antimalarial drug chloroquine, piperaquine and photographic agents, photosensitive materials, is also used for synthesis of methyl sichuan and cyanine dyes.
the name of the original chinese formic acid ethyl ester three molecular formula hc (oc2h5) 3 molecular weight 148.20 cas 122-51-0
catalog
1.
2 physicochemical indexes
3 safety terminology
4 term risk
5 preparation
6 use
after the original use of formic acid ethyl ester three
after the original application of formic acid ethyl ester three
after the original three preparation methods of ethyl formate
the original 7 formic acid ethyl ester three safety instructions (msds)
after an overview of risk
after the emergency measures
after the fire measures
leakage after emergency treatment
after exposure controls / personal protection
after the original storage characteristics of formic acid ethyl ester three
overview of editing
chinese original name: formic acid ethyl ester three, aethon, 1,1', 1'' (methyl three (oxo) three) ethane, ethyl orthoformate.
english name: triethoxy methane, triethyl orthoformate, 1,1', 1''-[methylidynetris (oxy)]tris-ethane, orthoformic acid, triethyl ester, 1,1', 1'- (methylidynetris (oxy)) tris (ethane). 1,1,1-triethoxymethane; aethon; akos bbs-00004276; ethone; ethyl-o-formate; ethyl orthoformate; orthoformic acid triethyl ester; teof; triethoxymethane; triethyl-o-formate; 1 - (diethoxymethoxy was; 1,1 ', 1' - (methylidynetris (oxy)) tris (was); 1,1 ', 1' - (methylidynetris (oxy
)) tris (was); 1,1 ', 1' '-[methylidynetris (oxy)]tris-ethan; 1,1', 1 '' -[methylidynetris (oxy)]tris-ethane; ethane, 1,1 ', 1''-[methylidynetris (oxy)]tris-; ethane, 1,1', 1 '' -[methylidynetris (oxy)]tris-; ethyl formate (ortho); ethylester kyseliny orthomravenci
einecs number: 204-550-4[1]
this product is toxic protective low toxicity, oral ld50 for rats was 7.06g/kg.
physicochemical index editing
appearance: colorless liquid.
aroma: pungent odor, ethereal atmosphere, long short.
relative density: 0.8909 (20/4 c).
melting point: <-18 c.
the boiling point of 143 deg c: (102kpa).
flash point: 27 degrees.
the refractive index nd (25): 1.3900.
solubility: with ethanol, ether soluble, slightly soluble in water.
stability: stability, water decomposition.
security terminology editing
away from sources of ignition. s16keep
away from the fire source.
case of contact with eyes s26in rinse immediately with plenty of water and seek medical advice.
after contact with eyes, rinse immediately with plenty of water and seek medical advice.
suitable gloves and eye/face protection s37/39wear
wear suitable gloves and goggles and masks.
risk term editor
r10flammable.
flammable.
to eyes and skin. r36/38irritating
irritating to eyes and skin.
irritating to eyes. r36
stimulate the eyes.
preparation and editing
1 ethanol sodium method to ethanol sodium and chloroform as raw materials, the reaction at 60-65 degrees, the original three ethyl formate crude products, and then refined by fractionation.
2 ethanol method with ethanol and sodium hydroxide instead of ethanol sodium, using solid - liquid phase transfer catalysis, the catalyst is ptc.
3. benzoyl chloride method from benzoyl chloride; formamide and anhydrous ethanol as raw material, under the action of a catalyst generated triethyl orthoformate; a mixture of benzoic acid and ammonium chloride. the separation was finished products or raw acid triethyl and benzoic acid.
use of three ethyl ester of formic acid
[use] is used as raw material for preparing antimalarial drug chloroquine, piperaquine and photographic agents, photosensitive materials, and can also be used to synthesis a sichuan and cyanine dyes
[use two] for organic synthesis
[purpose] triethyl orthoformate is acaricide long a pair of amidines and herbicide pyrazosulfuron ethyl intermediates, can also be used for of the antimalarial drug chloroquine, piperaquine and other drugs.
[four] the use of pharmaceutical raw materials, is the raw material for the synthesis of antimalarial drugs such as chloroquine and piperaquine. also used for making polymers, photographic chemicals, photographic materials, antihalation dye, cyanine dyes and synthetic pesticides etc..
[five] the use of pharmaceutical raw materials, is the raw material for the synthesis of antimalarial drugs such as chloroquine and piperaquine. also used for making polymers; photographic chemicals; photographic materials; antihalation dye; cyanine dyes and synthetic pesticides etc..
application field of ethyl formate three
as a raw material for preparation of chloroquine, piperaquine and photographic chemicals, photographic materials, but also for the synthesis of methine and cyanine dyes
method for preparing ethyl three ethyl ester
[method] the preparation method is in a reaction kettle chloroform was added and stirred, heat to 55 deg c, dropping sodium ethoxide ethanol solution, reaction temperature control in 60 ~ 65 deg c, and bi gradually warming up to 70 deg c, thermal insulation 1h. at the end of the reaction ph<8, filtered sodium chloride and fractionation of the filtrate was crude, and distillation to obtain the finished product. 3c2h5ona+chcl3 (ch) 3+3nacl (oc2h5)
safety manual (msds) editor of the original formic acid three ethyl ester
risk overview
[health hazards] oral administration can cause dyspnea and weakness. no irritation to skin.
[flammable and explosive danger] this product is flammable. its vapor and air can form explosive mixtures.
first aid measure
skin contact, remove contaminated clothing, wash with flowing water.
to lift the eyelids, flush with flowing water or saline. medical treatment.
rapidly from the scene to the fresh air. maintain airway patency. if breathing is difficult, give oxygen. if breathing has stopped, artificial respiration immediately. medical treatment.
[food] drink enough water to vomit. medical treatment.
fire protection measures
[characteristics] dangerous flammable, in case of fire, heat or contact with oxidizing agent, there is the risk of combustion and explosion. the vapor is heavier than air, can arrive at a far place lower spread, will encounter fire fire backdraft.
[] harmful products of combustion of carbon monoxide and carbon dioxide.
[method] the fire water cooling containers, if possible containers from fire to open. extinguishing media: foam, dry powder, carbon dioxide, sand.
emergency treatment
[emergency] leakage of contaminated areas to evacuate personnel to a safe area and isolation and restricted entry. cut off the fire. recommended emergency personnel wear self positive pressure respirator, wear anti-static overalls. as far as possible to cut off the source of leakage. to prevent the inflow of sewage, flood channel limited space. a small leak: absorb with sand or other non combustible material or adsorption. you can also rinse with plenty of water, wash water diluted into the wastewater system. a large leak: construct a barrierpit to contain. covered with foam, reduce the vapor hazard. explosion proof pump transferred to tankexclusive collector, place the disposal of recycling or shipped to the waste disposal.
exposure controls / personal protection
[control] engineering production process closed, strengthening ventilation. provide a safety shower and eyewash equipment.
[respiratory protection] generally do not need special protection, but under special circumstances, wear self absorption filter mask (half mask).
[protection] eyes generally do not need special protection, can wear safety glasses with high concentration of contact.
[protection] body wear anti-static overalls.
[hand] wear protective oil resistant rubber gloves.
[protection] smoking is prohibited in other work site. after work, take a shower. pay attention to personal hygiene.
three ethyl orthoformate storage characteristics
[note] the operation of closed operation, strengthening ventilation. the operator must go through specialized training, strictly abide by the rules. it is suggested that the operators should wear anti-static clothing, wear rubber oil resistant gloves. keep away from fire and heat, smoking is prohibited in the workplace. use explosion-proof ventilation systems and equipment. to prevent steam leakage in the air of workplace. avoid contacting with oxidant and acid. filling to control flow, prevent the accumulation of static electricity. when moving to light light unloading, prevent damage to packaging and containers. equipped with corresponding quantity and variety of fire equipment and emergency treatment equipment. empty containers may be harmful remains.
[note] storage store in a cool, ventilated warehouse. keep away from fire and heat source. the temperature should not exceed 30 deg c. keep the container sealed. should be stored separately with oxidant and acid, avoid mixing reservoir. explosion-proof lighting and ventilation facilities. mechanical equipment and tools to prohibit the use of easy to produce the spark. storage areas should be equipped with emergency treatment equipment and proper acceptancematerials.