CAS: 2627-69-2 Acadesine factory sales CAS NO.2627-69-2

description:

name:acadesine

cas number: 2627-69-2

purity: ≥98%

molecular formula: c9h14n4o5

molecular weight: 258.2

human growth hormone//aicar//acadesine//cas no.2627-69-2 large in stock

aicar (aica riboside) strongly inhibits the transcription of ppar&alpha and the coactivation of ppar&alpha. in adipocyte

studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. additionally, research indicates that aicar blocks the differentiation of 3t3-l1 (sc-2243) adipocytes. studies demonstrate that aicar can mimic the activity of insulin (sc-211647) by activating ampk (amp-activated protein kinase), and affecting the expression of pepck-m (pepck) and glucose-6-phosphatase (g6pase). the 5-aminoimidazole-4-carboxamide ribonucleoside (zmp) is the monophosphorylated derivative of aica-riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (atic). aicar is an inhibitor of hsp90, mtor and p70 s6 kinase.

amp activated protein kinase (ampk) functions as a metabolic sensor that regulates lipid and glucose metabolism to

maintain cellular energy homeostasis and to protect against metabolic stress.aicar is a selective activator of ampk in both hepatocytes and adipocytes. at 0.5 mm it inhibits the synthesis of fatty acids and sterols and inactivates hmg-coa reductase in rat hepatocytes.aicar (0.5 mm) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces glut4 translocation 2.5-fold in 3t3-l1 adipocytes. it also blocks the expression of pro-inflammatory cytokines (tnf-α/il-1β and il-6), inos, cox-2, and mnsod genes in glial cells and macrophages by inhibiting nfκb and c/ebp pathways.

biological activity:aicar is a cell permeable activator of amp-activated protein kinase (ampk), a metabolic master regulator that is activated in times of reduced energy availability (high cellular amp:atp ratios) and serves to inhibit anabolic processes. in vivo, pharmacologic activation of ampk with aicar mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle.

cell-permeable, allosteric activator of amp-activated protein kinase (ampk). augments proliferation, differentiation and mineralization of osteoblastic mc3t3-ei cells and attenuates psychosine-induced expression of proinflammatory cytokines and inos in astrocytes. promotes osteogenic differentiation of hamscs and bm-mscs in vitro.

function

aicar also known as zmp is an analog of amp that is capable of stimulating amp-dependent protein kinase activity (ampk). aicar is being clinically used to treat and protect against cardiac ischemic injury. if left untreated, it may lead to a myocardial infarct. cardiac ischemia is caused by insufficient blood flow and oxygen to the myocardium .the drug was first used in the 1980’s as a method to preserve blood flow to the heart during surgery. currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

application

(1) applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.

(2) applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.

(3) applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.

specification

advantages:

1)material:

owning cultivation base as 100% natural material stable source.

2)production equipment:

spotless extraction pots, high pressure compression pots, enamel reaction vessel , spraying tower, freezed-dry oven;systematic fermentation plant;

testing equipment: uv, hplc, gc

3)supply ability:

production capacity: 5000kg/month, large stock available;

supplying conventional and customized plant extract products.

reservations was accepted in chemical products.