Welcome to LookChem.com Sign In|Join Free
  • or
HENAN SUNLAKE ENTERPRISE CORPORATIONCAS:566-48-3 C19H26O3 Formestane//file1.lookchem.com/cas/reactions/2021/07/14/4198373.png
qq

You May Like:

Communicate with Supplier:

Ms. summer
Ms. summer: What can I do for you?

CAS:566-48-3 C19H26O3 Formestane CAS NO.566-48-3

Min.Order Quantity:
500 Gram
Purity:
99%
Port:
depend on clients require
Payment Terms:
L/C,T/T,MoneyGram

Add to Inquiry Cart

Product Details

Keywords

  • CAS:566-48-3 C19H26O3 Formestane
  • CAS:566-48-3 C19H26O3
  • CAS:566-48-3

Quick Details

  • ProName: CAS:566-48-3 C19H26O3 Formestane
  • CasNo: 566-48-3
  • Molecular Formula: C19H26O3
  • Appearance: white poweder
  • Application: CAS:566-48-3 C19H26O3 Formestane
  • DeliveryTime: 5 working days after cash deposit
  • PackAge: Plastic vacuum packaging bag or bucket
  • Port: depend on clients require
  • ProductionCapacity: 1 Metric Ton/Day
  • Purity: 99%
  • Storage: under the cool and dry area
  • Transportation: by express or by sea
  • LimitNum: 500 Gram
  • Grade: Industrial Grade,Pharma Grade,Electron...

Superiority

formestane basic information
anti-cancer drugs chemical properties application production method
product name: formestane
synonyms: 4-hydroxy-androst-4-ene-17-dione;4-hydroxy-delta(sub4)-androstenedione;4-hydroxyandrost-4-ene-3,17-dione;4-hydroxyandrostenedione;4-hydroxy-4-androstene-3,17-dione;4-androsten-4-ol-3,17-dione;4-oha;cgp-32349
cas: 566-48-3
mf: c19h26o3
mw: 302.41
einecs:
product categories: pharmaceutical raw materials;miscellaneous biochemicals;inhibitors;intermediates & fine chemicals;pharmaceuticals;steroids;anti-cancer&immunity
mol file: 566-48-3.mol
formestane structure
formestane chemical properties
mp 199-202°c
storage temp. 2-8°c
form solid
cas database reference 566-48-3(cas database reference)
safety information
hazard codes t
risk statements 60
safety statements 53-36/37/39-45
wgk germany 3
rtecs bv8152500
msds information
provider language
formestane english
sigmaaldrich english
formestane usage and synthesis
anti-cancer drugs formestane also known as lentaron,is an anti-cancer drug, it is primarily used for the treatment of postmenopausal women with advanced breast cancer, it is also effective in prostate cancer.
formestane is a androstenedione derivative, and it belongs to an aromatase inhibitor with aminoglutethimide, it is a hormone antineoplastic agent. in physiological conditions, it may competitively inhibit the synthesis of the enzyme leading to estrogen biosynthesis decrease in tissues, then it plays its role in cancer. when the tumor tissue growth relies on the presence of estrogen, in order to inhibit tumor growth, the elimination of tumor estrogen-mediated growth stimulation is necessary. this product is more selective than aminoglutethimide while its activity is 100 to 1000 times of aminoglutethimide, and it does not inhibit the synthesis of adrenal hormones，without having to recharge cortisone, etc . the in vitro inhibition of aromatase enzyme of this product is 60 times stronger than aminoglutethimide.
while it is used alone, the drug can not significantly reduce the pre-menopausal estrogen levels in the blood of women,when it is combined with goserelin (gonadotropin-releasing hormone agonist)， its inhibitory effect of estrogen in premenopausal women is greater than goserelin used alone. formestane has no cross-resistance with other aromatase inhibitors , it has no side effects of aminoglutethimide. after oral administration，it is rapidly absorbed by gastrointestinal, its peak plasma concentration time is 1 to 1.5 hours, but the peak concentration of individual is of great difference; after intramuscular injection，it can be accumulated at the injection site and be slowly absorbed. it performs biphasic elimination process, the initial elimination half-life is 2 to 4 days, the terminal elimination half-life is 5 to 10 days. it is mainly metabolized in the liver after oral administration, in the form of glycosides acid metabolites excreted in the urine.
the above information is edited by the chemicalbook of tian ye.
chemical properties crystallized from aqueous methanol, m.p. 199 ~ 202 ℃; crystallized from ethyl acetate, m.p. 203.5 ~ 206 ℃. uv absorption maximum (99.5% ethanol): 278nm (ε11030). [α] d20 + 181 ° (c = 7.7, chloroform).
application aromatase inhibitors ,it is used for progressive breast cancer.
male hormones, assimilating protein class.
production method androst-4-ene-3,17-dione (ⅰ) (1.432g, 5mmo1) is dissolved in 50ml tert-butanol ,add 38mg (0.15mmo1) osmium tetroxide in 2ml t-butanol solution at room temperature, and then 5ml 35% hydrogen peroxide is added, followed by stirring at room temperature for 3 days. after dilution of 100ml brine, and extract with dichloromethane (2 × 100m1). the extract is washed with 100ml brine, , 50ml 10% sodium bisulfite solution, 50ml 10% sodium carbonate solution and 100ml brine, dry over anhydrous sodium sulfate, and concentrate. the residue (1.824g) of the compound (ⅱ), is dissolved in methanol (10ml),add potassium hydroxide (393mg, 7mmo1) in 3ml methanol . plus albert, stirring 10min at 55 ℃. add 0.3ml of acetic acid and 100ml of brine, and extract with dichloromethane (2 × 100ml). complex solution, combine, wash with 100ml brine, dry with anhydrous sodium sulfate, and concentrate. the residue (1.727g) by column chromatography on silica gel, wash with hexane - ethyl acetate (7: 3) to give 715mg formestane, yield 47%, mp 200 ~ 202 ℃ (acetone).
chemical properties needles
usage an antitumor drug. an aromatase inhibitor
usage antineoplastic, aromatase inhibitor
formestane preparation products and raw materials
raw materials ethyl acetate-->dichloromethane-->sodium carbonate-->sodium sulfate-->potassium hydroxide -->tert-butanol-->acetylacetone-->osmium tetraoxide

Details

our services

1. top quality

2. competitive price

3. fast feedback

4. excellent after-sale service

5. safe delivery

our advantage

1. risk-free guarantee,15days refund

2. most of the products in stock,can ship within 2days after the order
3. stable quality and supply ability,samsung,lg,merck,dow,ge, supplier

4.iso9001,iso14001,rosh certification

5. duns registered,d-u-n-s number :530844988,give you the confidence to do business with us!

6. we can supply custom synthesis service.

sunlake can quickly and efficiently provide a variety of organic compounds, oled intermediates .main including: carbazole, fluorene, anthracene, boronic acid, naphthaline, thiophene, imidazole derivatives and so on. also can provide custom synthesis from the laboratory scale to commercial production.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Related Products

Related Keywords

Inquiry Cart 0