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Kono Chem Co.,LtdCAS:59865-13-3 Cyclosporin A//file1.lookchem.com/cas/reactions/2021/07/21/3647785.png
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CAS:59865-13-3 Cyclosporin A CAS NO.59865-13-3

Min.Order Quantity:
1 Kilogram
Purity:
99.5%
Port:
all chinese port
Payment Terms:
T/T,MoneyGram,Other

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Product Details

Keywords

  • Cyclosporin A
  • Cyclosporin A
  • Cyclosporine

Quick Details

  • ProName: CAS:59865-13-3 Cyclosporin A
  • CasNo: 59865-13-3
  • Molecular Formula: C62H111N11O12
  • Appearance: White powder
  • Application: Medicine
  • DeliveryTime: within 3-4days after received your pay...
  • PackAge: according to customers' requirements
  • Port: all chinese port
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99.5%
  • Storage: store in cool and dry
  • Transportation: by sea or by air
  • LimitNum: 1 Kilogram

Superiority

loss on drying
2.0%max
heavy metals
0.002% max
boiling point(°c)
1293.8°c at 760 mmhg
flash point(°c)
736.3°c
density
1.016g/cm3
individual impurity
0.7% max
sum of all impurity
1.5% max
assay
98.5%∼101.5%
standard
usp29

description

cyclosporine or cyclosporine a, is an immunosuppressant drug. cyclosporine widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. cyclosporine has been studied in transplants of skin, heart, kidney, liver, lung, pancreas, bone marrow, and small intestine. cyclosporine initially isolated from the fungus tolypocladium inflatum isolated from a soil, ciclosporine is a cyclicnonribosomal peptide of 11 amino acids and contains a single d-amino acid, which are rarely encountered in nature.

cyclosporine is thought to bind to the cytosolic protein cyclophilin(immunophilin) of immunocompetent lymphocytes, especially t-lymphocytes. this complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2. in t-cells, activation of the t-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. calcineurin then dephosphorylates the transcription factor nf-at (nuclear factor of activated t-cells), which moves to the nucleus of the t-cell and increases the activity of genes coding for il-2 and related cytokines. ciclosporin prevents the dephosphorlyation of nf-at by binding to cyclophilin.[7] it also inhibits lymphokine production andinterleukin release and, therefore, leads to a reduced function of effector t-cells. it does not affect cytostaticactivity.

it also has an effect on mitochondria. ciclosporine prevents the mitochondrial permeability transition pore from opening, thus inhibiting cytochrome c release, a potent apoptotic stimulation factor. however, this is not the primary mechanism of action for clinical use, but rather an important effect for research on apoptosis

application

1) it is an immunosuppressant drug.

2) cyclosporin a is widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection.

Details

kono chem co.,ltd is a leading producer of standardized herbal extracts, natural active ingredients and apis for pharmaceutical, health food and cosmetic industries.

the botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by pioneer. they include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

with our phytopharmaceutical background and knowledge through experience, pioneer can also provide a wide range of analytical services and reference substances to our clients. in addition, we also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: sam-e tosylate disulfate; sam-e 1,4-butanedisulfonate; polycytidylic acid; polyinosinic acid; adenosine triphosphate disodium; and cytidine triphosphate disodium; these items are our strongest advantage in china. meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

recently, kono chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. as a gmp standardized manufacturer, our products can meet or even exceed the standards of cp2010, usp32, bp2005 and ep4. presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as usa, eu, south america and southeast asia. there are experienced technicians working for our institutes now, all of them are skilled. pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.

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