cas 84625-61-6 active pharmaceutical ingredients itraconazole for systemic fungal infections

• quick detail of active pharmaceutical ingredients metoclopramide itraconazole :

cas 84625-61-6 active pharmaceutical ingredients itraconazole for systemic fungal infectionscas 84625-61-6 active pharmaceutical ingredients itraconazole for systemic fungal infections

product name: itraconazole

synonyms:

sporanox;r51211;oriconazole;triasporin;-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihyd;3h-1,2,4-triazol-3-one,4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1h-1,2,4-triazol;ro-2-(1-methylpropyl)-;itraconazole-d3;

cas: 84625-61-6;

mf: c35h38cl2n8o4;

mw: 705.63.

product name:	itraconazole
other name:	metoclopramide hydrochloride, monohydrate;gastresel.a;gastrobidcontinus;metoclopramidehydrochloride, monohydrate,usp;gastromax;4-amino-5-chloro-n-(2-diethylaminoethyl)-2-methoxybenzamide hydrochloride;metoclopramide hydrochloride;benzamide, 4-amino-5-chloro-n-(2-(diethylamino)ethyl)-2-methoxy-, monohydrochloride, monohydrate;
original:	china
cas:	84625-61-6
molecular formula:	c35h38cl2n8o4
mw:	705.63
brand name	xinrunde
leading time	within 24 hours upon receipt of payment
delivery	fast and secure shipping by ems, dhl, tnt, fedex, ups
purity	99%
package	discreet and hidden package according to specific requirement
appearance	white crystals
certification	sgs, iso 9001, kosher
payment terms	, money gram , t/t, bitcoin
minimum order quantity	10g
price	negotiable
usage	it can be used for the treatment of systemic fungal infections, such as aspergillosis, candidiasis, cryptococcosis (including cryptococcal meningitis), histoplasmosis, sporotrichosis, paracoccidioides brasiliensis disease
molecular structure

• description of active pharmaceutical ingredients itraconazole:

itraconazole is an artificially synthetic clotrimazole, being a broad-spectrum synthetic antifungal agent. its antimicrobial spectrum and antimicrobial mechanism is similar to clotrimazole, but has strong antibacterial activity against aspergillus.

it exerts its anti-fungal effect through changing the fungal cell membrane permeability with antibacterial activity against superficial and deep fungal pathogens. its antibacterial spectrum is broader and stronger than ketoconazole, being able to inhibit the ergosterol synthesis of fungal cell membrane, thus playing the antifungal effect.

this product is suitable for the treatment of dermatophytes (trichophyton, microsporum, flocculent epidermophyton), yeast [cryptococcus neoformans, pityrosporum, candida (including candida albicans, candida glabrata and candida krusei)], aspergillus, histoplasma, paracoccidioides brasiliensis, sporothrix schenckii, hormodendrum, cladosporium, blastomyces dermatitidis and various kinds of other types of yeasts and fungi. itraconazole is not able to inhibit the growth of rhizopus and mucor.

• medical usage of active pharmaceutical ingredients itraconazole:

the imidazole antifungal agents for the triazole ring, through inhibiting the activation of cytochrome p-450, including oxidase and peroxidase, disable the 14, alpha-methyl sterols to be dehydrogenated and be converted to ergosterol, so that the growth and proliferation of fungi are inhibited. they have strong lipophilicity and penetrate through the biofilm to inhibit the binding of the membrane to the fungus.

the antibacterial spectrum is similar to ketoconazole. it is effective in the treatment of superficial fungal diseases such as vaginal and oral candidiasis as well as skin mycosis. furthermore, it is expected to become the highly-efficient and safe drugs for the treatment of deep fungal infections such as cryptococcal encephalitis (aids). it is used for the treatment of vulvovaginal candidiasis, pityriasis and skin fungal disease pityriasis caused by sensitive fungi.

it can be used for the synthesis of broad-spectrum azole antifungal agents for the treatment of systemic infection caused by deep fungus. it can also be used for the treatment of candidiasis and aspergillosis.

it is used for the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

it is anti fungal and used in the treatment of stomach upset/ indigestion and other gastrointestinal conditions.