CAS No.865-47-4 Potassium tert-butoxide CAS NO.865-47-4

Min.Order Quantity:: 1 Kilogram

Purity:: 98.0%Min

Port:: Shanghai port

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Keywords

865-47-4
Potassium tert-butoxide
98%

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ProName: CAS No.865-47-4 Potassium tert-butoxi...
CasNo: 865-47-4
Molecular Formula: C4H9KO
Appearance: Powder
Application: Pharma intermediates
DeliveryTime: PROMPT
PackAge: 1KG -200KG Drum with pallet
Port: Shanghai port
ProductionCapacity: 50 Metric Ton/Month
Purity: 98.0%Min
Storage: Flammables area
Transportation: by sea or by air or by courier
LimitNum: 1 Kilogram

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cas no.865-47-4

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potassium tert-butoxide basic information

strong organic alkaline related chemical reaction strong alkaline condensing agent laboratory method for preparation of potassium tert-butoxide precautions uses

product name:	potassium tert-butoxide
synonyms:	buok(potassium tert-butoxide);potassium tert-butoxide reagent grade, >=98%;potassium tert-butoxide solution 1.0 m in thf;potassium tert-butoxide sublimed grade, 99.99% trace metals basis;potassium tert-butoxide, 1.0 m solution in tert-butanol , spcseal;potassium tert-butoxide, 1.0 m solution in thf, spcseal;potassium tert-butoxide, 1.8 m solution in thf, spcseal;potassium tert-butyl alcohol
cas:	865-47-4
mf:	c4h9ko
mw:	112.21
einecs:	212-740-3
product categories:	pharmaceutical intermediates;straight chain compounds;classes of metal compounds;k (potassium) compounds (excluding simple potassium salts);typical metal compounds;micro/nanoelectronics;chemical synthesis;organic bases;synthetic reagents;organic basesmicro/nanoelectronics;potassium;solution deposition precursors;metal alkoxide;25ml sure/seal reagents;chemical synthesis;materials science;organic bases;organometallic reagents;solution deposition precursors;synthetic reagents
mol file:	865-47-4.mol

potassium tert-butoxide chemical properties

melting point	256-258 °c (dec.)(lit.)
boiling point	275°c
density	0.910 g/ml at 20 °c
vapor pressure	1 mm hg ( 220 °c)
fp	54 °f
storage temp.	flammables area
solubility	soluble in hexane, toluene, diethyl ether and terahydrofuran.
form	solution
color	white to off-white
ph	13 (5g/l, h2o, 20℃)hydrolysis
water solubility	reacts
sensitive	moisture sensitive
brn	3556712
stability:	stable, but reacts violently with water and acids, possibly leading to fire. incompatible with water, acids, halogenated hydrocarbons, alcohols, strong oxidizing agents, ketones, carbon dioxide.
inchikey	lpnyryfbwfdtma-uhfffaoysa-n
cas database reference	865-47-4(cas database reference)
epa substance registry system	2-propanol, 2-methyl-, potassium salt(865-47-4)

safety information

hazard codes	f,c,xi
risk statements	11-19-22-34-35-14-20-36/37-37
safety statements	16-26-36/37/39-43-45-7/9-8-43a-33-27-29
ridadr	un 3274 3/pg 2
wgk germany	1
f	10-21
hazard note	flammable solid/corrosive
tsca	yes
hazardclass	8
packinggroup	i
hs code	29051900

potassium tert-butoxide usage and synthesis

strong organic alkaline	potassium tert-butoxide is an important kind of organic base with its alkalinity being stronger than potassium hydroxide. because of the induction effect of three methyl groups in the (ch3) 3co-, it has stronger alkalinity and activity than other potassium alkoxides, thus being a very excellent catalyst. in addition, as a kind of strong alkaline, potassium tert-butoxide is widely used in the organic synthesis of chemical, pharmaceutical, and pesticide such as trans-esterification, condensation, rearrangement, polymerization, loop opening and the production of heavy metal orthoester. it can be used to catalyze the michael addition reaction, pinacol rearrangement reaction and ramberg-backlund rearrangement reaction. potassium tert-butoxide is used as a condensing agent, which can be used to catalyze darzens condensation reaction and stobbe condensation reaction. it is also the most effective alkaline for traditional akloxide-haloform reaction generating dihalogenated carbene. therefore, potassium tert-butoxide has attracted more and more attention from chemical, pharmaceutical, pesticide and other industries. as potassium tert-butoxide has such a wide application, the domestic and international demand for high purity potassium tert-butoxide is very large. however, due to its production cost is higher than other alkali metal alkoxides, the production technology needs to be improved, so in-depth study of potassium tert-butoxide is particularly important.
related chemical reaction	1, take n-formyl-o-toluidine as raw material, 350~360 °c, have it reacted with potassium tert-butoxide to generate indole. after separation, the indole is further reacted with chloroacetic acid reaction to obtain β-indole acetic acid. 2, β-ring citral is first reacted with acrylic magnesium bromide to have grignard reaction to generate alcohol, the resulting alcohol is then oxidized into ketone, followed by isomerization using potassium tert-butoxide as a catalyst to become β-ketone. 3, take citral and allyl grignard reagents as raw materials for reaction to generate 6, 10-dimethyl-4-hydroxy-1, 5, 9-undecatriene, followed by the oxidation reaction by collins reagent to generate 6, 10-dimethyl-1,5,9-undecatrien-4-one, which is then subject to isomerization under the action of tert-butanol potassium to generate damascone. the damascone, under the action of tin chloride or phosphoric acid, can have cyclization to obtain damascenone. 4, take 2, 6, 6-trimethylcyclohexane-2-alkenyl formaldehyde to have reaction with allyl grignard agent to generate cyclohexenyl butenol, followed by the oxidation under copper-zinc catalyst to generate cyclohexane alkenyl ketene, followed by isomerization in the alkali solution of potassium tert-butoxide, being able to generate damascenone. 5, darzen reaction: aldehydes and ketones, in the presence of alkaline reagents, can have ester-aldol condensation reaction with α-halo acid ester, while having the hydrogen halogen lost, generating α, β-epoxy ester. common alkaline reagents include sodium ethoxide, sodium amide, sodium metal, potassium tert-butoxide and so on. 6. stobbe reaction: aldehydes, ketones and succinate ester, in the presence of alkaline catalysts (such as sodium ethoxide, potassium tert-butoxide, sodium chloride, etc.) have reaction similar to the aldol condensation reaction, generating succinate or its monoester with the methylene replaced by hydrocarbon.
strong alkaline condensing agent	potassium tert-butoxide is a strong alkaline condensing agent with its alkalinity is stronger than sodium methoxide and sodium ethoxide. at room temperature, this product is white or white-like solid powder with its chemical formula being (ch3) 3c-o-k, molecular weight being 112.21, density being 0.929, the melting point of 256-258 ° c and the boiling point being 275 ° c. it is easy to absorb moisture. it is soluble in tert-butanol with the solution being relative stable, and commonly used in the dehydrohalogenation reaction of halogenated hydrocarbon. being exposure to air decomposition, it can be decomposed into potassium oxide and tert-butyl alcohol when coming across water. it can be manufactured through the reaction between butanol and potassium, followed by the vacuum distillation of tert-butanol in the system. it is widely used the condensation reaction, rearrangement and ring-opening reaction in organic synthesis. people generally apply tert-butanol solution. potassium tert-butoxide is a kind of organic alkaline corrosion products with strong moisture absorption property and should be sealed for storage. we need to pay attention to prevention of fire and sunshine during the storage and transportation. it should be stored in a cool, ventilated and dry place.
laboratory method for preparation of potassium tert-butoxide	the potassium metal was added to the freshly distilled tert-butanol under nitrogen atmosphere, refluxed to until the potassium was completely melted. further incubate for 1 hour. the excess amount of t-butyl alcohol was distilled off with the remaining white solid subjecting to vacuum drying under reduced pressure at 180-190 °c for 10 h. then we can obtain the crystal powder of potassium tert-butanol. it needs to saved be under the nitrogen atmosphere for using. it should be kept away from air & water, or will become pink. the yield, calculated according to potassium, is more than 99%. the chemical reaction equation for the reaction between tert-butyl alcohol and metal potassium for preparation of potassium tert-butoxide is as follows:
precautions	potassium tert-butoxide has two types, liquid and solid. usually the liquid industrial product is the tert-butanol solution of tert-butanol potassium with the color of the product being light yellow or milky white, being slightly turbid, in which the content of potassium tert-butoxide being 10% to 12%; the solid product is generally white or white powder in which the potassium tert-butoxide content is 95% to 97%. potassium tert-butoxide is organic alkaline corrosion product with strong moisture absorption property. it should be generally sealed for storage, generally stored in a cool, dry, ventilated warehouse. it should be kept away from heat and isolated from fire isolation as well as being protected from sun exposure. potassium tert-butoxide has a strong corrosive effect on the skin. during the handling and loading process, the operator should wear a protective mask to prevent corrosion and burning by potassium tert-butoxide. the above information is edited by tongtong from chemicalbook.
uses	it can be used in pesticides, pharmaceuticals, printing and dyeing, catalysts and so on potassium tert-butoxide, as a strong alkaline, is widely used in the condensation, rearrangement and ring opening reaction in organic production in the fields of chemical, pharmaceutical and pesticide.
chemical properties	white crystalline powder
uses	usually used for greener amidation of esters.