USD $100.00-100.00 / Kilogram
USD $10.00-90.00 / Kilogram
USD $8.80-8.80 / Gram
USD $10.00-90.00 / Kilogram
USD $2.00-2.00 / Gram
USD $1.00-10.00 / Kilogram
USD $2.00-2.00 / Gram
USD $2.00-2.00 / Gram
english name: capecitabine
used in the treatment of metastatic breast and colorectal cancers
(skype:pamelasurvivor)
1.introduction of capecitabine
the capecitabine, with the cas registry number 154361-50-9, is also known as n(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine. it belongs to the product categories of active pharmaceutical ingredients; antineoplastic; bases & related reagents; intermediates & fine chemicals; nucleotides; pharmaceuticals; antineoplastic drug, 5-fu analog; anti-cancer. this chemical's molecular formula is c15h22fn3o6 and molecular weight is 359.35. what's more, its systematic name is 5'-deoxy-5-fluoro-n-
[(pentyloxy)carbonyl]cytidine. its classification codes are: (1)antimetabolites; (2)antimetabolites, antineoplastic; (3)antineoplastic; (4)antineoplastic agents; (5)noxae . this chemical is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. capecitabine is a prodrug of doxifluridine and an antineoplastic agent , that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits dna synthesis and slows growth of tumor tissue.
2.physical properties of capecitabine
(1)acd/logp: 1.042; (2)# of rule of 5 violations: 0; (3)acd/logd (ph 5.5): 0.76; (4)acd/logd (ph 7.4): -0.60; (5)acd/bcf (ph 5.5): 1.89; (6)acd/bcf (ph 7.4): 1.00; (7)acd/koc (ph 5.5): 45.62; (8)acd/koc (ph 7.4): 2.02; (9)#h bond acceptors: 9; (10)#h bond donors: 3; (11)#freely rotating bonds: 8; (12)polar surface area: 120.69 2; (13)index of refraction: 1.6; (14)molar refractivity: 82.327 cm3; (15)molar volume: 240.522 cm3; (16)polarizability: 32.637 10-24cm3; (17)surface tension: 51.3009986877441 dyne/cm; (18)density: 1.494 g/cm3.
3.structure of capecitabine
(1)smiles: fc=1\c(=n/c(=o)n(c=1)[c@@h]2o[c@@h]([c@@h](o)[c@h]2o)c)\n
c(=o)occccc
(2)std. inchi: inchi=1s/c15h22fn3o6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-
11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21h,3-6h2,1-2h3,(h,17,18,22,23)/t8-,10-,11-,13-/m1/s1
(3)std. inchikey: gagwjhpbxlxjqn-uorftkchsa-n
4.pharmacodynamics of capecitabine
it is a fluoropyrimidine
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