Cheap best quality 474645-27-7 Monomethyl Auristatin E on hot selling CAS NO.474645-27-7

cheap best quality 474645-27-7 monomethyl auristatin e on hot selling

methyl aureusine e is an anti-silk divider that inhibits cell division by blocking the polymerization of microtube proteins and is a popular antibody conjugate drug (adc).

a methyl aureusine e short for mmae is a synthetic anti-tumor drug. because of its toxicity, it cannot be used as a drug in itself but is connected to monoclonal antibodies (mabs). it is an effective anti-silk splitting drug derived from a peptide called dolastatin, which is found in the marine shellless mollusc dolabellaauricularia. these peptides have been shown in preclinical studies to be effective in vitro and in vivo activity in a variety of lymphomas, leukemias and solid tumors. these drugs are up to 200 times more effective than changchun alkali.

application

monomethylauristatine (mmae; sgd-1010) is a synthetic derivative of sea rabbit toxin 10, which plays an effective role in mitotic inhibition by inhibiting the polymerization of microtube proteins (tubulin). mmae is widely used as a cytotoxic ingredient to make antibody-drug conjugates (adcs) to treat cancer.