Chenodeoxycholic Acid Manufacturer 474-25-9 Treatment Of Cholesterol Cholelithiasis CAS NO.474-25-9

Min.Order Quantity:: 10 Gram

Purity:: 99%

Port:: ShangHai

Payment Terms:: T/T,MoneyGram

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Keywords

99% Chenodeoxycholic Acid
Chenodeoxycholic Acid Manufacturer
Treatment Of Cholesterol Cholelithiasis

Quick Details

ProName: Chenodeoxycholic Acid Manufacturer 474...
CasNo: 474-25-9
Molecular Formula: C24H40O4
Appearance: White Powder
Application: It Can Be Used As Pharmaceutical Inte...
DeliveryTime: 2-4 days after confirming your payment...
PackAge: 100g/ bag, 2 kg/ bag, 25kg/ carton or ...
Port: ShangHai
ProductionCapacity: 10000 Metric Ton/Month
Purity: 99%
Storage: Store in sealed containers at cool & d...
Transportation: By DHL, TNT, FedEx, HKEMS, UPS, Etc
LimitNum: 10 Gram

Superiority

advantages:

hubei xinrunde chemical co., ltd is a renowned pharmaceutical manufacturer. we can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. never stop striving to offer our best service is our philosophy. we have flexible and untraceable payment terms. as a leading manufacture, our products have been exported to germany, norway, poland, finland, spain, uk, france, russia, usa, brazil, mexico, australia, japan, korea, thailand, indonesia, uruguay and many other countries.

1. quality.every batch of steroid powders have tobetested by our qc(quality control) before they are allowed to sell.

2. delivery we have stock, so we can delivery quickly at the very day when receive the payment. within 24 hours after receiving the payment lead time 4 or 7 days.

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4. warm after-sale service any of your question would be solved for the first as soon as possible.

Details

chenodeoxycholic acid basic information

product name:	chenodeoxycholic acid
synonyms:	(r)-4-((3r,7r,8r,9s,10s,13r,14s,17r)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid;(r)-4-((3r,5s,7r,10s,13r)-3,7-dihydroxy-10,13-dimethyl-hexadecahydro-1h-cyclopenta[a]phenanthren-17-yl)pentanoic acid;ursodeoxycholoc acid,3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;5β-cholanic acid-3α,7α-diol chenodiol;ursodeoxycholoc acid;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-dihydroxy-5-cholanicacid
cas:	474-25-9
mf:	c24h40o4
mw:	392.57
einecs:	207-481-8
product categories:	inhibitors;intermediates & fine chemicals;pharmaceuticals;steroids;intracellular receptor
mol file:	474-25-9.mol

chenodeoxycholic acid chemical properties

melting point	165-167 °c(lit.)
alpha	12 º (c=1, chcl3)
fp	9℃
storage temp.	refrigerator
solubility	practically insoluble
form	powder
color	white to off-white
water solubility	practically insoluble
merck	13,2062
cas database reference	474-25-9(cas database reference)
epa substance registry system	cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- (474-25-9)

safety information

hazard codes	xn
risk statements	63
safety statements	22-24/25-45-36/37
ridadr	un1230 - class 3 - pg 2 - methanol, solution
wgk germany	2
rtecs	fz1980000

chenodeoxycholic acid usage and synthesis

chemical properties	off-white solid
uses	chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase c signaling pathways.it is a major bile acid in many vertebrates, occurring as the n-glycine and/or n-taurine conjugate. with other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid x receptor (fxr), a nuclear receptor that regulates genes involved in lipid metabolism.they are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type ii diabetes, hyperlipidemia, and atherosclerosis. chenodeoxycholic acid is widely utilized in therapeutic applications. it is applied in medical therapy to dissolve gallstones. it is employed in the treatment of cerebrotendineous xanthomatosis. it is used to treat constipation and cerebrotendineous xanthomatosis. it acts as a urea receptor in supramolecular chemistry which can contain anions. it is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells. chenodeoxycholic acid is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells. this co-adsorbent will prevent dye aggregation on the semiconductor surface, reducing losses in the solar cell's operation. chenodeoxycholic acid is a white solid added with the dye powder to the solvent while preparing staining solutions. the concentration of co-adsorbent is typically 10 fold the dye concentration. chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (ctx). it has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies. chenodeoxycholic acid (cdca) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.ec50 concentrations for activation of fxr range from 13-34 μm.in cells, cdca also binds to bile acid binding proteins (babp) with a reported stoichiometry of 1:2.cdca toxicity is linked to increased cellular glutathione levels and increased oxidative stress. exposure of cells to excess cdca contributes to liver and intestinal cancers.
uses	anticholithogenic, antilipemic agent
uses	a major bile acid in many vertebrates, occurring as the n-glycine and/or n-taurine conjugate. with other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus fa cilitates its excretion. fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. anticholelithogenic. epimeric with ursodiol.
uses	an apoptosis inducer via pkc-dependent signalling pathway.