Cyclosporin A CAS NO.59865-13-3

1)basic information

immunosuppressants pharmacological effects pharmacokinetics indications drug interactions side effectschemical properties production methods

product name:	cyclosporin a
synonyms:	ol27-400;s7481f1;sandimmun;sandimmune;antibiotic s 7481f1;antibiotic s 7481fi;ciclosporin;ciclosporin a
cas:	59865-13-3
mf:	c62h111n11o12
mw:	1202.61
einecs:	200-835-2
product categories:	active pharmaceutical ingredients;organics;intermediates & fine chemicals;peptides;pharmaceuticals;protein phosphatase;signalling;kayquinone;antibiotic;anti-cancer&immunity;inhibitors
mol file:	59865-13-3.mol

2)chemical properties

mp	148-151°c
storage temp.	2-8°c
solubility	ethanol: 30 mg/ml
form	solid
color	white
merck	13,2781
cas database reference	59865-13-3(cas database reference)
epa substance registry system	cyclosporin a(59865-13-3)

3) usage

cyclosporin a is a hydrophobic cyclic peptide isolated from several fungal species including cylindrocarpon, fusarium, trichoderma and tolypocladium. cyclosporin a inhibits t-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. cyclosporin a acts by binding to the protein, cyclophilin (immunophilin), in t-lymphocytes causing inhibition of calcineurin (protein phosphatase 2b). cyclosporin a reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and no synthesis induced by interleukin 1α, lipopolysaccharides and tnfα.

company information

henan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team.

we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.