Dexrazoxane 24584-09-6 CAS NO.24584-09-6

dexrazoxane hydrochloride is a cardioprotective agent. it was discovered by kurt hellmann in 1972. dexrazoxane is a sterile, pyrogen-free lyophilizate intended for intravenous administration. the iv administration of dexrazoxane is in acidic condition with hcl adjusting the ph.

dexrazoxane has been used to protect the heart against the cardiotoxic side effects of chemotherapeutic drugs such as anthracyclines,such asdaunorubicin or doxorubicin or other chemotherapeutic agents.

guarantee the quality of dexrazoxane

specifications
therapeutic category : reduction of toxicity in oncological treatments with doxorubicin .
description : a white or slightly cream colored crystalline powder .
solubility: soluble in 0.1 n hydrochloric acid and in 0.1 n sodium hydroxide. insoluble in methanol, sparingly soluble in water .
ir spectrum (in kbr): must be coincident with the spectrum of the reference standard .
hplc: retention time must be coincident with the retention time of the reference standard .
melting point : within 191-197°c. the melting range must not exceed 2°c .
specific rotation : [ alpha ] 20 d +38° to + 41° (c=0.5%, h 2o
loss on drying : not more than 0.8% (82°c, 4 hours, 2 mm hg, over p2 o5 )
assay (hplc): 98%-102% on dry basis .
pyrogens :negative.