minoxidil
【product name】
6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide
【synonyms】
2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
2,4-diamino-6-piperidinopyrimidine 3-oxide
6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine
aalopexil
alostil
u-10,858
【cas】
38304-91-5
【formula】
c9h15n5o
【molecular weight】
209.25
【einecs】
253-874-2
【rtecs】
uv8200000
【rtecs class】
drug; reproductive effector; human data
【merck】
12,6290
【beilstein/gmelin】
886240
【beilstein reference】
5-25-12-00317
physical and chemical properties back to contents
【appearance】
crystals from methanol-acetonitrile. odorless. solutions are colorless to light yellow.
【melting point】
248
【pka/pkb】
4.61 (pka)
【usage】
medication.
first aid measures back to contents
【ingestion】
immediately seek medical assistance.
【inhalation】
remove from exposure. seek medical assistance.
【skin】
flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【eyes】
flush eyes with copious amounts of water. seek medical assistance.
handling and storage back to contents
【storage】
keep in a cool, dry location. keep containers closed when not in use. protect from light.
【handling】
all chemicals should be considered hazardous. avoid direct physical contact. use appropriate, approved safety equipment. untrained individuals should not handle this chemical or its container. handling should occur in a chemical fume hood.
hazards identification back to contents
【inhalation】
pulmonary edema has been reported following buflomedil overdoses. respiratory depression may occur with buflomedil intoxication.
【skin】
may cause irritation, allergic contact dermatitis.
【eyes】
burns, irritation.
【ingestion】
nausea and vomiting are common following therapeutic administration of fenoldopam.
exposure controls/personal protection back to contents
【personal protection】
chemical splash goggles in compliance with osha regulations are advised; however, osha regulations also permit other type safety glasses. whre chemical resistant gloves. to prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【respirators】
use niosh/msha approved respirator appropriate for exposure of concern.
【exposure effects】
headache, dizziness and sweating may occur with any of the vasodilators. peripheral neuropathy has been reported following long term hydralazine therapy. hyperglycemic, non-ketotic coma may occur with diazoxide. seizures and coma may occur with buflomedil toxicity.
fire fighting measures back to contents
【fire fighting】
extinguish using water, carbon dixoide or dry chemical powder. use a scba and full-body protective equipment.
accidental release measures back to contents
【small spills/leaks】
absorb spilled solutions wiht papter towls or other appropriate media. for solid, sweep up. transfer to suitable container for later disposal.
stability and reactivity back to contents
【stability】
stable at normal temperatures and pressures.