centella extract,gotu kola extract

synonyms

· dammarolic acid

· nsc 166063

· cas no.464-92-6

asiatic acid is a pentacyclic triterpene isolated from a variety of plants, including c. asiatica, used in traditional medicines. in addition to anti-inflammatory actions, asiatic acid stimulates wound healing by increasing collagen production.¹ it has also been found to induce cell cycle arrest and apoptosis in breast cancer cells (ic₅₀ = 5.9 µm for mcf-7 cells) and block angiogenesis in cells and tumors from glioblastomas.^2,3 asiatic acid also impacts amyloid-β precursor protein processing by down regulating bace1 while increasing adam10 maturation in primary rat cortical neurons.⁴ in addition, it reduces neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice while demonstrating protective effects against glutamate-induced apoptosis in isolated sh-sy5y cells.⁵