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HENAN SUNLAKE ENTERPRISE CORPORATIONHigh Qualiy Miconazole nitrate Supplier//file1.lookchem.com/cas/reactions/2021/07/08/4225531.png
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High Qualiy Miconazole nitrate Supplier CAS NO.22832-87-7

Min.Order Quantity:
10 Kilogram
Purity:
99%
Port:
Shanghai Port
Payment Terms:
L/C,D/A,D/P,T/T,MoneyGram,Other

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Product Details

Keywords

  • 1-[2,4-DICHLORO BETA-[2,4-DICHLOROBENZYL]OXY]-PHENETHYL]IMIDAZOLE NITRATE
  • 1-[2,4-DICHLORO-BETA-([2,4-DICHLOROBENZYL]OXY)-PHENETHYL]IMIDAZOLE NITRATE SALT
  • daktacort

Quick Details

  • ProName: High Qualiy Miconazole nitrate Supplie...
  • CasNo: 22832-87-7
  • Molecular Formula: C18H15Cl4N3O4
  • Appearance: White Powder
  • Application: API
  • DeliveryTime: 15-20 working days
  • PackAge: 25 kgs/drum
  • Port: Shanghai Port
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: 99%
  • Storage: dry, clean, cool place, avoid from sun...
  • Transportation: By sea
  • LimitNum: 10 Kilogram
  • Molecular Weight: 479.14

Superiority

henan sunlake enterprise corporation

our company advantages:

1、the highest quality with the competitive price.

2、professional human services.

3、the fastest and safest delivery service.

4、the faster and safest delivery service.

5、the high purity products.

6、we have a sufficient supply of stock.

7、a variety of payments, such as l/c, tt, , moneygram or other payments.

company information

henan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion. the com[any was established in june. 1998, until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others. these products have been being well exported to europe, southeast asia, the middle east ,africa, south america and some other countries and areas.

we sincerely welcome foreign friends to visit our plant for cooperation. with the idea of "quality first,credit priority, excellent service", we are highly acknowledged by customers for good quality and competitive price. more importantly , the company has a strong r & d team, who are professional engineers and scholars with ph. d. .so we are confident to serve you better with our high - quality products and professional team. we are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional supplier in international market.

we welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!

Details

miconazole nitrate basic information

pharmacological effects antifungals drug interactions application
product name: miconazole nitrate
synonyms: 1-[2,4-dichloro beta-[2,4-dichlorobenzyl]oxy]-phenethyl]imidazole nitrate;1-[2,4-dichloro-beta-([2,4-dichlorobenzyl]oxy)-phenethyl]imidazole nitrate salt;1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole nitrate;labotest-bb lt00134678;(+/-)miconazole nitrate salt;1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)-imidazolmononitra;1h-imidazole,1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl);daktacort
cas: 22832-87-7
mf: c18h15cl4n3o4
mw: 479.14
einecs: 245-256-6
product categories: active pharmaceutical ingredients;organics;antifungals for research and experimental use;biochemistry;api's;antifungal;aromatics;heterocycles;intermediates & fine chemicals;pharmaceuticals;monistat;api
mol file: 22832-87-7.mol
miconazole nitrate structure
miconazole nitrate chemical properties
mp 170-185 c
storage temp. store at rt
merck 6178
cas database reference 22832-87-7(cas database reference)
safety information
hazard codes xn
risk statements 22-43-40
safety statements 36/37
ridadr 3249
wgk germany 3
rtecs ni4771000
hazardclass 6.1(b)
packinggroup iii
msds information
provider language
sigmaaldrich english
miconazole nitrate usage and synthesis
pharmacological effects miconazole nitrate is a kind of artificially synthetic 1-phenylethyl imidazole derivatives and belongs to imidazole-class broad-spectrum antifungal drug. it is a commonly used drug for treating skin ringworm without containing hormones and without side effects. its main active ingredient is miconazole. however, miconazole nitrate is now seldom used in china. its antibacterial spectrum, antibacterial activity and mechanism of action are all similar with clotrimazole. it can be used as a substitute drug when the treatment of amphotericin in deep fungal infection is invalid. it is suitable for treating the systemic, disseminated infection caused by some kinds of fungus such as cryptococcus neoformans and candida albicans. the efficacy of absorption via oral administration is poor. after topical administration, the drug is mainly maintained in the lesion place with only a small fraction getting absorbed into the body. in vivo, it is widely distributed in various body tissues and fluids and can penetrate into the inflamed joints, vitreous and the peritoneum, but the concentration in the sputum and saliva is low and it has a poor penetrating capability through the blood - brain barrier and is difficult to penetrate through the blood-brain barrier. it has a plasma protein binding rate of 90%. it is mainly inactive through liver metabolism into inactive metabolites with 14% ~ 22% of the metabolites being excreted through urine, of which less than 1% of drug being in its prototype. 50% of the drug is excreted through the feces via in its prototype form. the half-life of the α-phase is 0.4 hour while the half-life of the β phase is 2.1 hours with the terminal half-life being 20 to 24 hours.
[mechanism of action of the miconazole nitrate]
1. it can interfere with the activity of cytochrome p450, inhibit the ergosterol biosynthesis of the fungal cell membrane, causing damage to the fungal cell membrane and changing its permeability, further resulting in the leakage of the important intracellular material.
2. it can inhibit the biosynthesis of the fungal triglyceride and phospholipid.
3. it can inhibit the activity of the oxidase and peroxidase enzyme, resulting in the excessive accumulation of the hydrogen peroxide inside the cell, further leading to the submicroscopic structural degeneration and necrosis of fungus.
4. to candida albicans, it can suppress the process of the transition from spores into aggressive hyphae.
[antimicrobial spectrum]
miconazole nitrate has an excellent antifungal effect against various kinds of deep fungi (such as candida albicans, aspergillus, cryptococcus neoformans, blastomycosis, coccidioidomycosis and torulopsis), some epidermis fungi and yeasts. it also has antibacterial effect against some kinds of gram-positive bacteria (such as staphylococcus, streptococcus) and bacillus (such as bacillus anthracis).
[clinical application]
1. for serious infections caused by candida species, including peritonitis, pneumonia and urinary tract infections. miconazole nitrate can also be used for treating the secondary infection caused by the gram-positive bacteria.
2. the local administration can be used for treating chronic and extensive mucocutaneous candidiasis, vulvovaginitis candidiasis, tinea, ringworm, jork itch, athlete’s foot, tinea versicoeor and paronychomycosis caused by various kinds of dermatophytes, yeast and other kinds of fungus.
3. intravenous administration of it can be used for treating serious cryptococcosis, coccidioidomycosis and vice coccidioidomycosis.
the above information is edited by the chemicalbook of dai xiongfeng.
antifungals miconazole nitrate is a kind of antifungal agent which is the drug ”dakelin” which we are familiar with as commonly used drugs for treating skin ringworm. it has various kinds of effects. it inhibit the biosynthesis of ergosterol which is the fungal cell membrane component, causing damage to the cell membrane structure, increasing the membrane permeability, resulting in the leakage of the intracellular components and inhibiting the glucose utilization, preventing the nutrient uptake, and finally leading to fungal cell death. it is therefore suitable for the treatment of tinea, jock itch, ringworm, athlete's foot, tinea versicolor and paronychomycosis as well as the vaginal infection and secondary infection caused by the yeast (such as candida) and gram-positive bacteria. it is also effective in treating otitis externa and bacterial skin infections.
the common adverse reactions and side effects of miconazole nitrate include: occasional allergy, blisters, burning feeling, redness, itching or other skin irritation. very rare angioedema, urticaria, eczema, contact dermatitis, erythema, pelvic pain (cramps), vaginal irritation, vaginal secretions and discomfort in the administration site.
drug interactions 1. when it is used in combination with anticoagulant drugs such as coumarin or indandione derivative, it can enhance the effects of the later drugs, leading to prolonged prothrombin time. the patient should be subject to close observation and monitoring of prothrombin time as well as adjustment of the dosage of the anti-coagulation drugs.
2. miconazole nitrate can be used to increase the cyclosporine blood concentration and could increase the risk of renal toxicity. therefore, when these two drugs are used in combination, we should monitor the blood concentration of cyclosporine.
3. rifampicin may enhance the metabolism of this product, increase the liver toxicity. when being used in combination with this drug, it can reduce the plasma concentration of this product, leading to the treatment failure. being used in combination with isoniazid may also reduce the blood concentration of this product. thus, we should be cautious when use those above drugs in combination with each other.
4. combination with phenytoin and miconazole nitrate can cause changes in metabolism of these two drugs, and prolong the peak time of this product. when use the two drugs in combination, we should closely monitor their reactions.
5. combination with hypoglycemic agent can lead to severe hypoglycemia due to inhibit the metabolism of the drug.
6. combination with cisapride should be tabooed because this can lead to inhibition of the cytochrome p450 metabolic pathways, further causing arrhythmia. there is also risk of arrhythmia when apply miconazole nitrate in combination with astemizole or terfenadin. therefore, this should also be avoided.
application it is a kind of broad-spectrum anti-fungal drug and can be applied to the treatment of deep fungal infections.
chemical properties white solid
usage an antifungal agent that inhibits platelet cyclooxygenase
usage antifungal (topical).
biological activity antifungal agent. inhibits lanosterol demethylase and induces formation of reactive oxygen species.
miconazole nitrate preparation products and raw materials
raw materials toluene-->sodium nitrite-->acetone-->isopropanol-->acetophenone-->imidazole-->aluminium-->3-chloroaniline-->aluminium isopropoxide

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