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Hubei Jusheng Technology Co., Ltd.,High purity Leflunomide with best price and good quality//file1.lookchem.com/cas/reactions/2021/05/31/4323174.png
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High purity Leflunomide with best price and good quality CAS NO.75706-12-6

Min.Order Quantity:
10 Gram
Purity:
98.0% - 102.0%
Port:
Wuhan, Shanghai, Guangzhou, Tianjin port
Payment Terms:
L/C,T/T,MoneyGram,Other

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Product Details

Keywords

  • Leflunomide
  • purity 99% Leflunomide
  • high quality cas 75706-12-6

Quick Details

  • ProName: High purity Leflunomide with best pric...
  • CasNo: 75706-12-6
  • Molecular Formula: C12H9F3N2O2
  • Appearance: off-white crystalline powder
  • Application: API
  • DeliveryTime: within in 5-7 working days after recei...
  • PackAge: 25kg/paper drum or as customers' requi...
  • Port: Wuhan, Shanghai, Guangzhou, Tianjin po...
  • ProductionCapacity: 250 Kilogram/Month
  • Purity: 98.0% - 102.0%
  • Storage: Keep container tightly closed in a coo...
  • Transportation: by sea/by express
  • LimitNum: 10 Gram
  • Grade: Pharma Grade

Superiority

1, high quality with competitive price:

we are manufacturer and can provide high quality products with factory price.

2, fast and safe delivery

1) parcels can be sent out within 24 hours after payment. tracking number is available.

2) secure and discreet shipment. you have various choices of transportation methods.

3, we have clients throughout the world.

1) professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.

2) market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility.

3) high quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

Details

basic information

product name:

leflunomide

synonyms:

leflunomide;hwa 486;alpha,alpha,alpha-trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide;5-methylisoxazole-4-(4-trifluoromethylcarboxanilide);5-methyl-n-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide;n-(4-trifluoromethylphenyl)-5-methylisoxazol-4-carboxamide;5-methylisoxazole-4-carboxylicacid(4-trifluoromethyl)anilide;5-methyl-n-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamid

cas:

75706-12-6

mf:

c12h9f3n2o2

mw:

270.21

product categories:

active pharmaceutical ingredients;api;osteoarthritis and rheumatoid arthritis;inhibitors;intermediates & fine chemicals;pharmaceuticals;cytokine signaling;aromatics;heterocycles;an immunosuppressive agent;cardene;other apis

mol file:

75706-12-6.mol

leflunomide structure

chemical properties

melting point

163-168°c

boiling point

289.3 °c at 760 mmhg

density

1.392 g/cm3

flashing point

128.8 °c

vapor pressure

0.0020000000949949 mmhg at 25°c

storage temp.

2-8°c

quality index

relative substances:

a ≤0.01% total impurite ≤0.4%

loss on drying:

≤3.0%

heavy metal:

≤10ppm

residue on ignition:

≤0.1%

content:

98.0%~102.0%

conclusion

(usp31) (bp2008)

usage and synthesis

chemical properties

off white crystalline solid

usage

an immunosuppressive. inhibits t and b cell proliferation. activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. therapeutical

vasodilator

anti-altzheimer therapeutic

biological activity

immunosuppressant agent. in vitro the active metabolite a77 1726 (rs-61980) inhibits dihydroorotate dehydrogenase (k i = 2.7 μ m) and de novo pyrimidine synthesis in t-cells; blocks lymphocyte cell cycle progression and proliferation. a77 1726 also inhibits anti-cd3/cd28-induced cytokine production in pbmc cells (ic 50 = 21-27 μ g/ml). in vivo reduces inflammation in several animal models of autoimmune disease, arthritis, asthma and graft rejection.

about us:

hubei jusheng technology co., ltd., is a large group corporation which engaged in the r&d and manufacture of chemicals, pharmaceuticals and intermediates. we have earned ourselves a good reputation at home and abroad with advanced technology, standardized management and well established service systerm. we have developed to a very famous group corporation enterprise in chemical industry step by step.

our main products:

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