High purity Sorafenib tosylate with good quality CAS NO.284461-73-0

product name:

sorafenib tosylate

synonyms:

sorafenib;sorafenib-d3;sorafenib tolsylate;raf1 kinase inhibitor ii;n-(4-chloro-3-(trifluoromethyl)phenyl)-((4-(2-(n-methyl-carbamoyl)(4-pyridyloxy))phenyl)amino)carboxamide;4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methyl-pyridine-2-carboxamide;bay 43-9006;sorafenib mesylate

cas:

284461-73-0

mf:

c21h16clf3n4o3

mw:

464.83

product categories:

sorafinib;molecular targeted antineoplastic;all inhibitors;anti-neoplastic;inhibitors;intermediates & fine chemicals;pharmaceuticals;pharmaceutical intermediate;amines;inhibitor;bay 43-9006

mol file:

284461-73-0.mol

chemical properties

melting point

202-204°c

boiling point

523.3 °c at 760 mmhg

density

1.454 g/cm3

flashing point

270.3 °c

storage temp.

-20°c freezer

usage and synthesis

chemical properties

light yellow solid

usage

a potent raf kinase inhibitor. antineoplastic

multiple kinase inhibitor targeting both raf kinase and receptor tyrosine kinases that promote angiogensis. antineoplastic.

sorafenib tosylate (bay 43-9006, nexavar) is a small molecular inhibitor of vegfr, pdgfr, c-raf and b-raf with ic50s of 18 nm, 10 nm, 3 nm and 15 nm, respectively.

sorafenib tosylate (bay 43-9006) is a multikinase inhibitor of raf-1, b-raf and vegfr-2 with ic50 of 6 nm, 22 nm and 90 nm, respectively.